Ameliorated effects of green tea extract on lead induced liver toxicity in rats

Mehana, El-Saed; Meki, A.-R.M.A.; Fazili, Khalid Majid

doi:10.1016/j.etp.2010.09.001

Cited by 101 publications

(64 citation statements)

References 29 publications

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“…Several researchers have reported that Pb-acetate developed hepatocellular damage as evident from a signifi cant elevation in blood serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), which corroborates our fi ndings [Mehana et al, 2012;Azoz & Raafat, 2012;Aziz, 2012]. Increasing of the serum activities of AST and ALT was a consequence of lead hepatotoxic effect [Todorovic, et al, 2005;Durgut, et al, 2008].…”

Section: Discussionsupporting

confidence: 78%

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Makawy¹,

Ashoush²,

Abd-El-Moneim³

2015

Pol. J. Food Nutr. Sci.

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The antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathological changes and genotoxicity in male mice. Total phenolic content and antioxidant activity of both extracts were evaluated. Two doses of both extracts (50 and 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500 ppm). Mice given mango extracts with Pb-acetate had signifi cantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. Mango extracts prevented the histopathological changes in liver induced by Pb-acetate and decreased the cytotoxicity of lead by increasing the ratio of PCE/NCE. Mango extract treatment reduced the DNA damage induced by Pb-acetate in liver as demonstrated by a reduction in micronuclei and decrease in tail length, tail DNA% and Olive tail moment. It can be concluded that mango by-product extracts have potential to protect from oxidative stress and genotoxicity of lead.Unauthenticated Download Date | 5/8/18 7:04 AM

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Section: Discussionsupporting

confidence: 78%

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Makawy¹,

Ashoush²,

Abd-El-Moneim³

2015

Pol. J. Food Nutr. Sci.

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“…17,29 Transaminases and ALP are considered important markers of hepatic injury because their increased level in blood serum is observed immediately post hepatic necrosis and hepatocellular membrane damage. 27,30 In the present study, AZT treated rodents showed a highly remarkable increase in ALT and ALP and these results are in agreement with the above report. In the present study, AZT treated rodents showed increased bilirubin levels and this observation demonstrate that this toxin-induced insult to the liver could also result in hyperbilirubinemia in addition to hepatocellular necrosis.…”

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confidence: 82%

Azidothymidine induces severe hematological toxicity and hepatic injury in Charles Foster rats

Pandey¹,

Singh²

2017

Int J Basic Clin Pharmacol

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Background: The present study aimed at evaluating the effects of azidothymidine (AZT) on hematologic and biochemical parameters in Charles Foster rats.Methods: Twelve adult healthy Charles Foster rats comprising of six male and six females were selected for study. Test rodents were divided into four groups containing three rodents each. Three males and three females served as control and remaining received AZT drug. Rodents were acclimatized for 10 days and drug was administered for 28 days. After the completion of drug administration, blood samples were collected and analyzed for hematologic parameters, i.e., Hemoglobin (Hb), Packed cell volume (PCV), red blood cell (RBC), Mean corpuscular hemoglobin concentration (MCHC), total leukocyte count (TLC), Mean corpuscular volume (MCV), Platelet count (Plt) using a Fully Automatic Fully Digital Hematology Cell Counter. In addition, biochemical parameters, were measured to assess the effects of AZT on rodent physiology. In-vivo histopathological studies were also performed on vital organs of rodents to understand the effects of drug at tissue level.Results: When compared with the control group, the data indicated a outstanding decrease in Hb, PCV, RBC, TLC and platelets in all test groups, whereas MCHC did not show any major reduction but MCV data suggested a slight increase. Among biochemical parameters, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). were found to be remarkably elevated along with elevated bilirubin and reduced albumin, pointing towards a possible liver damage which was later corroborated by liver histopathological study.Conclusions: Above results indicate azidothymidine to be a myelosuppresive and hepatotoxic drug and its usage as an anti-retro viral during highly active anti-retro viral therapy (HAART) regime should be strictly monitored.

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“…It causes degradation in proteins, lipids, and DNA (Halliwell & Gutteridge, 1990). Like kidney, liver is one of the targets for lead and mercury; it reacts by increasing the activity of transaminases (Mehana et al, 2012;Agarwal et al, 2007) in acute intoxication. Here, in chronic study both LA and HgCl 2 attenuated antioxidants levels and expression and increased liver transaminases.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

Baiomy¹,

Soliman²,

Saad³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Heavy metals that normally cause problems are mercury (HgCl 2 ) and lead acetate (LA). Chelating and inhibitor agents are the target to treat and overcome metal toxicity. The current study has been carried out to evaluate the protective effects of N-acetyl cysteine (NAC) and meso 2,3 dimercaptosuccinic acid (DMSA) against HgCl 2 and LA toxicity. Materials and Methods: Ninety male Wistar rats were divided into nine equal groups. The groups were administered NAC and/or DMSA in presence or absence of LA (LA; 0.2% in drinking water) or HgCl 2 (2 mg/kg BW) for 2 consecutive months. Serum and organs were collected for biochemical, genetic and histopathological changes. Results: Biochemical results revealed that LA and HgCl 2 significantly increased the levels of liver and kidney biomarkers. Administration of NAC and DMSA considerably improved these altered changes. LA and HgCl 2 decreased serum levels of antioxidants and were ameliorated in NAC and DMSA administered rats. LA and HgCl 2 administration upregulated expression of IL-1β and IL-8 that were normalized by NAC and DMSA. Kidneys of LA and HgCl 2 groups showed intraluminal hyaline casts. Kidneys of DMSA-administrated rats showed mild hydropic degeneration of renal tubular epithelium in LA and HgCl 2 groups. Kidneys of NAC administrated rats showed atrophy of capillary tufts. Kidneys of LA and HgCl 2 administered rats which received DMSA and NAC showed normal glomerular structure. Liver histopathology showed sever changes that were ameliorated by NAC and DMSA. Conclusion: Taken together, usage of NAC and DMSA provide significant protection against LA and HgCl 2 -induced hepatotoxicity and nephrotoxicity in male Wistar rats.

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Ameliorated effects of green tea extract on lead induced liver toxicity in rats

Cited by 101 publications

References 29 publications

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Azidothymidine induces severe hematological toxicity and hepatic injury in Charles Foster rats

Protective Effect of Some Chelating Agents and Antioxidants on the Biohazards Produced From Water Pollution by Heavy Metals in Wistar Rats: Biological, Genetic and Histopathological Study

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