Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides

Progressive disruption of neurodevelopment by mid‐gestation exposure to lipopolysaccharides and the ameliorating effect of continuous alpha‐glycosyl isoquercitrin treatment

“…31 In this model, we also found that continuous AGIQ treatment, starting from late gestation, effectively ameliorates neonatal LPS exposure-induced ASD-like behavioral changes and disruptive hippocampal neurogenesis by suppressing initial pro-inflammatory responses and oxidative stress. 31 The current study was conducted in an LPS-induced MIA model to investigate the impact of disrupted hippocampal neurogenesis on target cell populations and on episodic memory formation, as well as other behavioral endpoints in offspring. To test the primary role of neuroinflammation and oxidative stress on the disruption of brain functions induced by maternal LPS treatment, we also examined the chemopreventive effect of AGIQ as an antioxidant and antiinflammatory agent.…”

“…45 These findings indicate that the degree and timing of neuroinflammatory responses may be dependent on MIA, and that the dose of LPS natal LPS injection, likely through antioxidant effects. 31 Therefore, the dosing regimen of AGIQ might be effective at suppressing MIA.…”

“…The dose of AGIQ in the present study has been shown chemopreventive effect on neonatal LPS exposure-induced deficits by continuous exposure from the embryo-fetal stages to adulthood. 31 BW, and food and water consumption of dams were measured every 1-4 days throughout the experimental period. Because blood levels of sex steroids during the estrous cycle influence neurogenesis, 32 male offspring were subjected to all analyses in the present study.…”

“…All behavioral tests were conducted in a behavior testroom adjacent to the animal room, and apparatuses used and procedures applied in each test were similar to the previous study. 31 In each behavioral test, all apparatuses were cleaned with a 70% ethanol solution each time each animal was tested. After each test, each animal was promptly returned to the home cage and moved to the animal room.…”

Enzymatically Modified Isoquercitrin: Production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms

“…In the study by Okano et al [ 64 ] in a rat model, it was also demonstrated that EMIQ treatment (0.25 and 0.5% in the diet), initiated in late pregnancy and continued into adulthood, suppressed the LPS-induced neurobehavioral changes in the offspring, similar to the symptoms of autism spectrum disorder. The detailed histopathological and immunochemical assays revealed that EMIQ ameliorates the pro-inflammatory and oxidative responses caused by LPS that lead to brain damage.…”