Ameliorating effect of troxerutin in unilateral ureteral obstruction induced renal oxidative stress, inflammation, and apoptosis in male rats

Kaeidi, Ayat; Taghipour, Zahra; Allahtavakoli, Mohammad; Fatemi, Iman; Hakimizadeh, Elham; Hassanshahi, Jalal

doi:10.1007/s00210-019-01801-4

Cited by 26 publications

(13 citation statements)

References 43 publications

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“…In the 5/6 nephrectomy, the activities of CAT, SOD, GPx, GR, and GST fall at 20 h in glomeruli, PT, and DT [128]. Moreover, early after UUO, these enzymes' mRNA and protein levels decrease, while oxidative markers increase [135]. Indeed, the decrease in antioxidant-system-induced OS has been suggested as a factor to induce the AKI to CKD transition.…”

Section: Oxidation and Os Production And In Kidney Diseasesmentioning

confidence: 99%

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

et al. 2021

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Mitochondria are essential organelles in physiology and kidney diseases, because they produce cellular energy required to perform their function. During mitochondrial metabolism, reactive oxygen species (ROS) are produced. ROS function as secondary messengers, inducing redox-sensitive post-translational modifications (PTM) in proteins and activating or deactivating different cell signaling pathways. However, in kidney diseases, ROS overproduction causes oxidative stress (OS), inducing mitochondrial dysfunction and altering its metabolism and dynamics. The latter processes are closely related to changes in the cell redox-sensitive signaling pathways, causing inflammation and apoptosis cell death. Although mitochondrial metabolism, ROS production, and OS have been studied in kidney diseases, the role of redox signaling pathways in mitochondria has not been addressed. This review focuses on altering the metabolism and dynamics of mitochondria through the dysregulation of redox-sensitive signaling pathways in kidney diseases.

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Section: Oxidation and Os Production And In Kidney Diseasesmentioning

confidence: 99%

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

et al. 2021

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“…Many active ingredients are tried for achieving these goals. Among them, calcium channel blockers that have previously been shown to be effective [31], fluuorofenidone which inhibits collagen-1 overexpression leading to renal fibrosis, indirectly antiapoptotic effect [32], angiotensin-2 receptor antagonists fimasartan [33], erythropoietin receptor, bcl -2, erythropoietin, which has antiapoptotic effects by suppressing bcl-x1 mRNA release [34], rhein, which is thought to suppress the bax and bcl2 proteins associated with apoptosis [35], colchicine, which is suggested to be antiapoptotic by suppressing caspase-3 and fibronectin [36], bcl-2, molecules such as troxerutin [37], which is effective on many proteins such as bax, TNF-alpha, and Ulinastatin [38], which is used in the treatment of acute pancreatitis and whose antiapoptotic effect has been tested in the cell damage that occurs in the brain, has been shown to reduce the pathological degeneration in the tissue by affecting the mechanisms that cause apoptosis in the UUO kidney.…”

Section: Discussionmentioning

confidence: 99%

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

Uçak¹,

Topçu²,

Sarı³

2020

Journal of Surgery and Medicine

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“…Every kidney section was measured for in ammatory cell in ltration, glomerular atrophy, and tubular necrosis. The renal tubulointerstitial injury was evaluated semi-quantitatively according to previous studies (Kaeidi et al, 2020b, Kaeidi et al, 2020c. Every liver section was measured for congestion and pyknosis.…”

Section: Histopathological Analysismentioning

confidence: 99%

“…Antioxidants are essential substances that are capable of guarding the body from free radical-induced oxidative stress damage (Kaeidi et al, 2020a, Kaeidi et al, 2020c. CaD (calcium 2, 5dihydroxybenzenesulfonate) is a vascular protective drug that is used for treatment of diabetic retinopathy and chronic venous insu ciency Ruiz, 1998, Berthet et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Calcium Dobesilate Administration Against Hepatorenal Damage Induced By CCL4 In Male Mice

Hakimizadeh

Kaeidi

Rahmani

et al. 2021

Preprint

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Purpose: Calcium dobesilate (CaD) has antioxidant and anti-inflammatory properties. In this study, the protective effects of CaD against hepatorenal damage induced by CCL4 in male mice were evaluated. Methods: Thirty male mice randomly were divided into five groups: Control, CaD 100 mg/kg, CCL4, CCL4+CaD 50 mg/kg, and CCL4+CaD 100 mg/kg. Drugs were administered orally once a day for 4-weeks. The liver and kidney indices (serum creatinine, blood urine nitrogen, alanine aminotransferase and aspartate aminotransferase levels) were determined. Also, hepatic and renal tissue oxidant/antioxidant markers (glutathione peroxidase, malondialdehyde, total antioxidant capacity, and superoxide dismutase) were measured. Cleaved caspase-3, Bax, and Bcl-2 protein levels were measured by immunoblotting method. The liver and kidney histopathological changes were evaluated by H&E staining.Results: CCL4 induces significant oxidative stress in the kidney and liver that was concomitant with functional and histopathological abnormalities in these organs in the CCL4 group versus the control (P<0.05). CaD could significantly improve the histopathological change in the liver and kidney tissues of CCL4+CaD 100 mg/kg mice versus the CCL4 group (P<0.05). In addition, CaD attenuated apoptosis in the liver and kidney tissues (P<0.05).Conclusion: The protective effect of CaD may be related to its anti-inflammatory and antioxidant properties.

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Ameliorating effect of troxerutin in unilateral ureteral obstruction induced renal oxidative stress, inflammation, and apoptosis in male rats

Cited by 26 publications

References 43 publications

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Mitochondrial Redox Signaling and Oxidative Stress in Kidney Diseases

Analysis of apoptosis of kidney tissue by the tunel method and histomorphological changes in rabbit kidney model due to unilateral supravesical obstruction

Protective Effect of Calcium Dobesilate Administration Against Hepatorenal Damage Induced By CCL4 In Male Mice

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