Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats

Swelam, Eman S.; Abdallah, Ibrahim; Mossa, Abdel‐Tawab H.

doi:10.3923/jpt.2017.24.32

Cited by 12 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with the previous findings [ 24 , 37 , 38 ], we found an oxidant/antioxidant imbalance in the FPN-treated rats. FPN increased the MDA level, an indicator of lipid peroxidation that is associated with a significant depletion in the antioxidant enzyme levels (SOD, CAT, GPx, and GSH) in the livers of rats treated with FPN.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, the immunohistochemical investigation of the liver revealed strong expression of the apoptosis marker, caspase-3, in the FPN group when compared to the control. This is in accordance with the previous investigations that reported that FPN increased caspase-3 in the hepatocytes isolated from rats [ 38 ] and that other pesticides, such as chlorpyrifos, caused apoptosis in human cell lines by stimulating caspase-3 [ 41 , 42 ]. The overexpression of caspase-3 may be linked to the increased hepatic oxidative stress and inflammation, indicating that FPN triggers oxidative stress and inflammation, which subsequently stimulates downstream apoptotic pathways.…”

Section: Discussionsupporting

confidence: 93%

“…In the same vein, a previous investigation recorded hepatocyte degeneration, congested central veins, and focal individual cell necrosis in the liver of rats exposed to FPN [24]. In accordance with the previous findings [24,37,38], we found an oxidant/antioxidant imbalance in the FPN-treated rats. FPN increased the MDA level, an indicator of lipid peroxidation that is associated with a significant depletion in the antioxidant enzyme levels (SOD, CAT, GPx, and GSH) in the livers of rats treated with FPN.…”

Section: Discussionsupporting

confidence: 92%

See 2 more Smart Citations

Synergistic effects of sitagliptin and losartan against fipronil-induced hepatotoxicity in rats

2021

View full text Add to dashboard Cite

Background and Aim: Fipronil (FPN) is a potent pesticide that is heavily used around the world in agriculture. However, its irrational use could potentially have deleterious effects on animals and humans. The present study aimed to investigate the ability of sitagliptin (Sit) and losartan (LOS), when used both individually or concurrently, to guard rat liver against the acute hepatotoxicity caused by FPN. Materials and Methods: Forty-two adult male Wistar rats were equally divided into seven groups (6/group). Group I (control) received normal saline (0.5 mL/rat, vehicle for all treatments) by gavage once daily for 10 days. Group II received oral Sit (10 mg/kg body weight [BW]) daily for 10 days and Group III received oral LOS (5 mg/kg BW) daily for 10 days. Group IV received oral FPN (19.4 mg/kg BW; 1/5 of the oral LD50) for the past 5 days of the study. Groups V and VI received oral Sit (10 mg/kg BW) and LOS (5 mg/kg BW) daily, respectively, 5 days prior and 5 days during FPN administration (19.4 mg/kg BW). Group VII received oral Sit (10 mg/kg BW) and LOS (5 mg/kg BW) for 10 days with daily FPN during the past 5 days. After the end of the treatment period, the rats were humanely sacrificed and blood and liver tissue samples were collected for biochemical analysis and histopathological and immunohistochemical investigations. Results: FPN administration resulted in elevated alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase serum concentrations as well as increased malondialdehyde levels and reduced catalase, superoxide dismutase, glutathione peroxidase, and glutathione activity. The histopathological investigation showed disorganization of the hepatic cords and focal necrosis of the hepatocytes in FPN-intoxicated rats. Furthermore, the immunohistochemical examination showed that hepatic caspase-3 was overexpressed in the FPN-treated rats. The administration of Sit and LOS before and alongside FPN markedly mitigated the alterations caused by FPN and the hepatoprotective effects were more prominent in the combination group. Conclusion: Sit and LOS, both individually or in combination, confers considerable hepatoprotection against FPN-induced hepatotoxicity.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Synergistic effects of sitagliptin and losartan against fipronil-induced hepatotoxicity in rats

2021

View full text Add to dashboard Cite

show abstract

“…Also, Zn treatment resulted in an elevation in the levels catalase according to (Goel et al, 2005). The protective effect of zinc on CAT activity may be owed to antiperoxidative property of this metal ion, which in turn leads to decrease in production of superoxide radicals (Swelam et al, 2017). Zinc has also a role as co-enzyme of SOD and it may have antioxidant properties (Powell, 2000).…”

Section: Discussionmentioning

confidence: 99%

Zinc nanoparticles coated with Gallic acid potentially ameliorate hepatocellular carcinoma-induced in rats

Shoker

Abouzaid

El-Sonbaty

2019

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

Materials on the nanoscale are increasingly being targeted to cancer cells with great specificity through both active and passive targeting. In the current study, the potential therapeutic effect of the newly synthesized Zinc nanoparticles coated with Gallic acid (Zn-GANPs) against hepatocellular carcinoma (HCC) -induced in rats were evaluated. Forty rats were divided into four equal groups, group 1: normal control, group 2: received diethylnitrosamine (DEN) (20 mg/Kg b.wt, 5 times per week for 8 weeks), group 3: received Zn-GANPs (20 mg/kg b. wt./day, i.p) from the onset of the 9th week till the end of the experiment (13 weeks), group 4: DEN + Zn-GANPs treated group: Rats were received DEN as group (2) and subsequently treated with Zn-GANPs as group (3) till the end of the experiment (13 weeks).Blood samples and liver tissue specimens were collected for biochemical analysis and histopathological examination. The obtained results revealed that in HCC-induced rats serum aspartate aminotransferase (AST) activity, total bilirubin and creatinine levels were increased, while total protein, albumin concentrations and liver catalase activity were significantly decreased as compared with control normal group. Administration of Zn-GANPs to HCC-induced rats non-significantly reduced serum AST activity, total bilirubin and creatinine concentrations. However, serum total protein and albumin levels were non-significantly increase and liver catalase activity was markedly increased in Zn-GANPs treated liver cancer group. Ameliorative effect of Zn-GANPs was appreciated with the histopathological alterations observed in DEN groups. These results suggesting the efficacy of Zn-GaNPs administration as an anti-HCC Cytotoxicity HCC HepG2 cell line Liver function tests Zn-GANPs

show abstract

“…Because fipronil is widely used in the veterinary, agricultural, and home sectors, there is a growing risk of contamination of food, water, and air as well as exposure to people, domestic animals, and the environment, all of which can have negative consequences. (Swelam et al, 2017) [15] . Pesticide exposure can happen orally, by inhalation or through the skin, and it can have harmful consequences on aquatic, animal, and human health.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Fipronil toxicity following subacute dermal exposure in rats

Patel,

Dewangan,

Rajput

et al. 2024

Int. J. Adv. Biochem. Res.

View full text Add to dashboard Cite

Fipronil is a phenyl pyrazole, broad-spectrum insecticide, used for control of pests in veterinary and agriculture sector. Present study was designed to evaluate the toxicity of fipronil following daily dermal application in Albino rats for 28 days. Rats were divided in to three groups having six animals in each group. Group I was treated as control and rats in group II and III were dermally applied with fipronil at dose 100 and 200 mg.kg -1 b.wt. Respectively daily for 28 days. Hematological and biochemical parameters were determined at 0, 14 th and 28 th day of exposure. The present investigation resulted in significant elevation in aspartate amino transaminase, alanine amino transaminase, alkaline phosphatase, lactate dehydrogenase activities in fipronil treated rats at both dose levels, indicated liver damage Fipronil also induced kidney damage as evidenced by significant increase in blood urea nitrogen and creatinine level. Also, the effect of fipronil on biochemical parameters was dose dependent. However, no significant changes on hematological parameters were observed at both the doses of fipronil during exposure period. Present study suggests hepatic and renal toxicity potential of fipronil following repeated dermal exposure.

show abstract

Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats

Cited by 12 publications

References 0 publications

Synergistic effects of sitagliptin and losartan against fipronil-induced hepatotoxicity in rats

Synergistic effects of sitagliptin and losartan against fipronil-induced hepatotoxicity in rats

Zinc nanoparticles coated with Gallic acid potentially ameliorate hepatocellular carcinoma-induced in rats

Assessment of Fipronil toxicity following subacute dermal exposure in rats

Contact Info

Product

Resources

About