Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

Bejeshk, Mohammad Abbas; Aminizadeh, Amir Hashem; Rajizadeh, Mohammad Amin; Rostamabadi, Fahimeh; Bagheri, Fatemeh; Khaksari, Mohammad; Azimi, Maryam

doi:10.1016/j.heliyon.2023.e22355

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22355

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Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

Mohammad Abbas Bejeshk,

Amir Hashem Aminizadeh,

Mohammad Amin Rajizadeh

et al.

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2024

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Cited by 3 publications

References 74 publications

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The use of herbal medicine in patients with inflammatory bowel disorders in Iran: A cross-sectional study

Shamsaddini,

Hasheminasab,

Raeiszadeh

et al. 2024

European Journal of Integrative Medicine

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The use of herbal medicine in patients with inflammatory bowel disorders in Iran: A cross-sectional study

Shamsaddini,

Hasheminasab,

Raeiszadeh

et al. 2024

European Journal of Integrative Medicine

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Mimosa pudica leaf aqueous extract attenuates experimental ulcerative colitis in rats via suppression of MPO and IL-1β signaling pathways and improvement of the oxidative status

Munasi,

Fotio,

Tagne

et al. 2024

Phytomedicine Plus

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Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats

Antwi-Adjei,

Obese,

Adakudugu

et al. 2024

Asian Pacific Journal of Tropical Biomedicine

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Objective: To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis. Methods: Rats were randomly divided into six groups: normal control, negative control, positive control (dexamethasone or sulfasalazine) as well as Persicaria lanigera (100-600 mg/kg)-treated groups. The effects of the extracts on body weight, antioxidant, and hematological parameters, as well as mast cell proliferation, were assessed. In addition, a histological evaluation was conducted. Results: Persicaria lanigera extract significantly decreased the mean exudate amount and suppressed granuloma tissue formation in a concentration-dependent manner in rats (P<0.05). Additionally, the extract significantly increased body weight, improved hematological profile, reduced the disease activity index score and malondialdehyde level, as well as enhanced catalase and superoxide dismutase activities (P<0.05). Histological evaluation showed Persicaria lanigera extract alleviated acetic acid-induced colonic damages, as evidenced by decreased cell necrosis, edema, and inflammatory cell infiltration. Conclusions: Persicaria lanigera extract possesses antiproliferative, antioxidative, and anti-colitis activities. However, its underlying mechanisms of action need further investigation.

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Ameliorating effects of Acacia arabica and Ocimum basilicum on acetic acid-induced ulcerative colitis model through mitigation of inflammation and oxidative stress

Cited by 3 publications

References 74 publications

The use of herbal medicine in patients with inflammatory bowel disorders in Iran: A cross-sectional study

The use of herbal medicine in patients with inflammatory bowel disorders in Iran: A cross-sectional study

Mimosa pudica leaf aqueous extract attenuates experimental ulcerative colitis in rats via suppression of MPO and IL-1β signaling pathways and improvement of the oxidative status

Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats

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