Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

Han, Jing‐Yan; Fan, Jing‐Yu; Horie, Yoshinori; Miura, Soichiro; Cui, Dehua; Ishii, Hiromasa; Hibi, Toshifumi; Tsuneki, Hiroshi; Kimura, Ikuko

doi:10.1016/j.pharmthera.2007.09.008

Cited by 307 publications

(215 citation statements)

References 130 publications

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“…Ischemia and reperfusion (I/R) exerts multiple injuries in microcirculation, frequently accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular efflux, production of oxygen free radicals, and mast cell degranulation [66]. Thus, much effort has been made to attenuate the microcirculatory disturbance by ablating one of the insults in the pathogenetic process.…”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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“…Many plant-derived terpenoids have been found to possess anti-inflammatory and anti-neoplastic properties, and TSA has been reported to modulate many kinds of biological activities, including the quenching of reactive oxygen species, and antagonism of calcium-promoted events. Such molecular changes may account for the ability of TSA to promote microcirculatory function, inhibit neutrophil migration, and exert anti-tumor effects (Han et al, 2008). TSA is able to traverse the blood brain barrier although the brain content is limited to 30% of 5 the plasma concentration (Chen et al, 2007), and this could relate to its effects in reducing the volume of cerebral infarction and maintenance of neuronal function (Lam et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8

Zhou¹,

Bondy

Liu

et al. 2015

Neuroscience

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“…It has been widely used for the microcirculatory disturbance and for the treatment of cardiovascular and cerebrovascular diseases, liver dysfunction, renal deficiency and vascular complications of diabetes (Han et al, 2008). Traditional Chinese Medicine (TCM) approach offers a holistic solution to prevent and eradicate bone disease.…”

Section: Discussionmentioning

confidence: 99%

“…This herbal medicine is isolated from dried roots of Salvia miltiorrhiza Bunge plant (Family: Lamiaceae, Genus: Salvia). SM has been widely used for the treatment of cardiovascular disease, hepatitis, hemorrhage and has antioxidant, anti-inflammatory, antimicrobial, antimenopausal syndrome, anti-ischemic activities and used in antineoplastic therapy (Cui et al, 2009;Han et al, 2008;Zhou et al, 2005;Zhu et al, 2004). Various clinical Abbreviations ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GSH-Px, glutathione peroxidase; MDA, malondialdehyde; SOD, superoxide dismutase.…”

mentioning

confidence: 99%

Salvia Miltiorrhiza Reinstates Growth Plate Width, Reduces Liver Oxidative Stress and Toxicity in Avian Tibial Dyschondroplasia

Nabi¹,

Zhang²,

Iqbal³

et al. 2018

PJZ

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Tibial dyschondroplasia (TD) is skeletal abnormality in rapidly growing birds causing carcass downgrading and severe welfare problems. Present study was aimed to determine specificity of salvia miltiorrhiza (SM) on growth plate width, liver oxidative stress and toxicity in avian TD. One hundred and fifty broiler chicks were equally distributed into three groups: Control, Thiram (50 mg/kg/d) and SM (10 mg/kg/d) treated. Results showed that thiram caused lameness, decrease in alkaline phosphatase (ALP) activity and increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in the serum along with decrease in level of antioxidant enzymes and significantly increase in the MDA contents in TD afflicted chickens compared to control group. The SM administration to TD affected birds significantly ameliorated lameness, stimulated ALP level with a decrease in ALT and AST contents, increase in antioxidant parameter and decrease in MDA contents significantly (P<0.05). SM treatment of TD-afflicted birds prevented lameness and reinstated antioxidant imbalance. SM may be effective for the treatment and control of TD and minimizing the liver damages caused by thiram in broiler chickens.T ibial dyschondroplasia (TD) is a major skeletal metabolic disease in fast growing birds. In TD, the growth plate bone fails to resorb and accumulates in the metaphyseal region causing lameness (Tian et al., 2013;Nabi et al., 2016a). TD is characterized as avascularized and non-mineralized cartilage in the growth plate (Tian et al., 2013). The etiology of TD is associated with several factors, however, most recent molecular studies showed that the occurrence of TD is associated with inhibition of angiogenesis, related genetic factors and genes contribute to bone vascularization and mineralization (Nabi et al., 2016a;Shahzad et al., 2015).Thiram (tetramethyl thiuram disulfide) is generally used as apesticide and fungicide in agriculture sector. Experimental addition of thiram to poultry feed induces TD.

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Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

Cited by 307 publications

References 130 publications

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8

Salvia Miltiorrhiza Reinstates Growth Plate Width, Reduces Liver Oxidative Stress and Toxicity in Avian Tibial Dyschondroplasia

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