Ameliorating effects of constituents from Cortex Acanthopanacis Radicis on memory impairment in mice induced by scopolamine

Nam, Young-Joo; Lee, Dongung

doi:10.1016/s0254-6272(14)60055-8

Cited by 12 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it was shown that sitosterolinduced ROS in turn elevates the expression of cyclooxygenase-2, resulting in an altered prostanoid profile, and ultimately endothelial dysfunction and angiogenesis [111]. In contrast, another study found stigmasterol to have a strong superoxide anion scavenging capacity, However, in this study, a supra-physiological concentration of stigmasterol was used (242 lM) [101]. Phytosterols have also been reported to possess anti-apoptotic properties in a endothelial cell line.…”

Section: Phytosterols and The Endothelium In Cns Disordersmentioning

confidence: 71%

“…Stigmasterol levels in brain were not measured directly but did affect the cerebral expression of memory-related proteins. It should be noted that the role of stigmasterol on acetylcholine esterase activity in vitro was found to be rather limited [101]. Together, phytosterols do not enhance cognition in normo-cognitive settings, whereas they do show a therapeutic potential during chemically induced and disease related cognitive impairment.…”

Section: Phytosterols In the Healthy Cnsmentioning

confidence: 94%

See 1 more Smart Citation

Plant sterols: Friend or foe in CNS disorders?

Vanmierlo

Bogie

Mailleux

et al. 2015

Progress in Lipid Research

View full text Add to dashboard Cite

In mammals, the central nervous system (CNS) is the most cholesterol rich organ by weight. Cholesterol metabolism is tightly regulated in the CNS and all cholesterol available is synthesized in situ. Deficits in cholesterol homeostasis at the level of synthesis, transport, or catabolism result in severe disorders featured by neurological disability. Recent studies indicate that a disturbed cholesterol metabolism is involved in CNS disorders, such as Alzheimer's disease (AD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). In contrast to circulating cholesterol, dietary plant sterols, can cross the blood-brain barrier and accumulate in the membranes of CNS cells. Plant sterols are well-known for their ability to lower circulating cholesterol levels. The finding that they gain access to the CNS has fueled research focusing on the physiological roles of plant sterols in the healthy and diseased CNS. To date, both beneficial and detrimental effects of plant sterols on CNS disorders are defined. In this review, we discuss recent findings regarding the impact of plant sterols on homeostatic and pathogenic processes in the CNS, and elaborate on the therapeutic potential of plant sterols in CNS disorders.

show abstract

Section: Phytosterols and The Endothelium In Cns Disordersmentioning

confidence: 71%

Section: Phytosterols In the Healthy Cnsmentioning

confidence: 94%

Plant sterols: Friend or foe in CNS disorders?

Vanmierlo

Bogie

Mailleux

et al. 2015

Progress in Lipid Research

View full text Add to dashboard Cite

show abstract

“…The next hit, piperine is known to inhibit ChEs, moreover curcumin and piperine are reported to synergically inhibit AChE and BChE in humans [ 64 ]. Sesamin is a phytochemical found in Cortex Acanthopanacis radicis , is reported to inhibit AChE, and known to improve memory impairment in mouse [ 65 ]. Lastly as represented earlier, ursolic and oleanolic acid from the leaves of C .…”

Section: Discussionmentioning

confidence: 99%

Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment

2022

View full text Add to dashboard Cite

Since its origin, the emergence of vector-borne infections has taken a toll on incalculable human lives. The use of chemical insecticides is one of the early known methods of vector control and although their use is still a prevalent way to combat insect population sadly the perils of insects related transmission still persists. Most commonly, the existing insecticides face the wrath of getting resisted repeatedly, paying way to develop resilient, efficient, and cost-effective natural insecticides. In this study, computational screening was performed using homology modelling, E-pharmacophore feature mapping, molecular docking, Density Function Theory (DFT) assessment, Molecular mechanics generalized Born surface area (MM-GBSA) based binding free energy calculations and Molecular Dynamics (MD) simulation to identify a potential lead phytochemical out of a manually curated library from published literature. The protein target used under this study is insect Butyrylcholine esterase (BChE). Additionally, in vitro insect (Aedes aegypti) BChE inhibition assay was also performed with the top phytochemical identified from in silico assessments. Our research highlights that curcumin leads to inhibition of enzyme BChE of Ae. aegypti. The identified mode of action of curcumin as an insect BChE inhibitor indicates the possibility of its use as an environment friendly and natural futuristic insecticide.

show abstract

“…Several unfavorable effects of phytosterols on endotheliumdependent vasorelaxation in wt mice have been reported [100][101][102][103]. The types and concentrations of phytosterols or their structure may determine and influence the production of superoxides by endothelial cells [101][102][103]. Collectively, these studies indicated that phytosterols could modulate various endothelium-dependent processes, such as vasorelaxation, oxidative stress, ischemia-reperfusion, and neuroinflammation, which are key biological processes in the progression of CNS disorders.…”

Section: Safety Concerns For the Phytosterolsmentioning

confidence: 98%

“…However, oxidized phytosterols were reported to exhibit neurotoxicity with glutamate excitotoxicity and ROS generation [87,99]. Several unfavorable effects of phytosterols on endotheliumdependent vasorelaxation in wt mice have been reported [100][101][102][103]. The types and concentrations of phytosterols or their structure may determine and influence the production of superoxides by endothelial cells [101][102][103].…”

Section: Safety Concerns For the Phytosterolsmentioning

confidence: 99%

Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

Sharma

Tan

2021

IJMS

View full text Add to dashboard Cite

Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal medicines. With many and diverse isolated structures in nature, they exhibit a broad range of biological and pharmacological activities. Among over 200 types of phytosterols, stigmasterol and β-sitosterol were ubiquitous in many plant species, exhibiting important aspects of activities related to neurodegenerative diseases. Hence, this mini-review presented an overview of the reported studies on selected phytosterols related to neurodegenerative diseases. It covered the major phytosterols based on biosynthetic considerations, including other phytosterols with significant in vitro and in vivo biological activities.

show abstract

Ameliorating effects of constituents from Cortex Acanthopanacis Radicis on memory impairment in mice induced by scopolamine

Abstract: Hyperin, a flavonoid glucoside isolated from Cortex Acanthopanacis Radicis, inhibited AChE activity and potently ameliorated scopolamine-induced memory impairment, and its action may be partially mediated by the acetylcholine-enhancing cholinergic nervous system.

Cited by 12 publications

References 14 publications

Plant sterols: Friend or foe in CNS disorders?

Plant sterols: Friend or foe in CNS disorders?

Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment

Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

Contact Info

Product

Resources

About