Ameliorating effects of dietary mixture of Withania somnifera root extract and vitamin C in Labeo rohita against low pH and waterborne iron stresses

Laltlanmawia, C.; Saha, Ratan K.; Saha, Himadri; Biswas, Pradyut

doi:10.1016/j.fsi.2018.09.008

Cited by 18 publications

(12 citation statements)

References 52 publications

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“…These findings are similar to those of Tiwari et al (2017) who documented a significant decrease in the activities of SGOT, SGPT and ALP in liver of Channa punctatus after their treatment with Melissa officinalis. Laltlanmawia et al (2019), also documented the stimulatory effect of 1.0% Withania sominifera and dietary L-ascorbic acid, which reduced the elevated activities of SGOT, SGPT and ALP in Labeo rohita as compared to control. Similarly, higher gene expression of immune relevant genes TLR-22 and β2-M was observed down regulated after a single dose treatment of miconazole nitrate in Labeo rohita fingerlings (Singh et al, 2018).…”

Section: Resultsmentioning

confidence: 79%

Ethanolic root extract of Rauwolfia serpentina alleviates copper induced genotoxicity and hepatic impairments in spotted snakehead fish, Channa punctatus (Bloch, 1793)

Trivedi¹,

Kumar²,

Singh³

et al. 2021

JEB

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Aim: The present study was designed to evaluate the plausible efficacy of ethanolic extract of Rauwolfia serpentina to mitigate copper induced toxicity by investigating cytogenetic biomarkers, i.e., chromosome aberrations (CA) and micronucleus (MN) formation; assessment of biochemical changes in liver enzymes (SGOT, SGPT and ALP) and estimation of protein levels in a freshwater spotted snakehead fish(Channa punctatus). Methodology: The experiment was carried out in six groups, each having 15 specimens for 24, 48, 72, and 96 hr. Group I served as control. Groups II and III were maintained with 3 mg l-1 of Rauwolfia root extract and 0.4 mg l-1 of Cu2+, respectively. Groups IV, V, and VI were simultaneously co-exposed with 0.4 mg l-1 of Cu2+ and three different concentrations of Rauwolfia root extract 1, 2 and 3 mg l-1, respectively. For the genotoxicity assessment, blood and kidney tissues were used. Hepatic impairments were assessed after each exposure period. Results: A significant increase (p<0.05) in chromosomal aberrations, micronuclei frequency, activity of liver enzymes (SGOT, SGPT and ALP) and a decrease in protein level were recorded in Group III in comparison to the control. Groups co-exposed with Cu2+and Rauwolfia serpentine showed a significant (p<0.05) decrease in cytogenetic biomarkers, activity of liver enzymes and an increase in protein levels, as compared to Group III, with respect to control in a dose dependent manner. Interpretation: Thus, result of the present investigation establish the efficacy of R. serpentina root extract against Cu2+ induced toxicity in spotted snakehead (Channa punctatus).

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Section: Resultsmentioning

confidence: 79%

Ethanolic root extract of Rauwolfia serpentina alleviates copper induced genotoxicity and hepatic impairments in spotted snakehead fish, Channa punctatus (Bloch, 1793)

Trivedi¹,

Kumar²,

Singh³

et al. 2021

JEB

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“…Withania somnifera root extract along with L-ascorbic acid (Vitamin C), significantly reduced the impacts of multiple stressors (low pH stress and waterborne iron stress) in L. rohita. 180 The anti-stress properties of the extract were attributed to the presence of active compounds such as sitoindosides VII-X and Withaferin-A. The role of Vitamin C as an antioxidant in order to prevent oxidative damage within cells was observed in terms of improved stress biomarkers.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 98%

“…A wide variety of environment-induced stressors have been studied across various aquatic animals. With reference to L. rohita, different biotic and abiotic stressors such as endosulfan stress, 171 crowding stress, 172 thermal stress, [173][174][175][176][177] pH stress, [178][179][180] light stress, 181 salinity stress, 174,175,182 nitrite stress, 183,184 Represents the optimum dosage achieved with the best significant results.…”

Section: Dietarysupplementationagainststressmentioning

confidence: 99%

“…Also, it was noted in the study that, 7 days feeding of phyto extract was able to induce the potent immune response while long‐term feeding resulted in immunosuppressive effects 179 . On the other hand, a combination of 1% Withania somnifera root extract along with L‐ascorbic acid (Vitamin C), significantly reduced the impacts of multiple stressors (low pH stress and waterborne iron stress) in L. rohita 180 . The anti‐stress properties of the extract were attributed to the presence of active compounds such as sitoindosides VII‐X and Withaferin‐A.…”

Section: Immunostimulantsmentioning

confidence: 99%

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Immunomodulation by dietary supplements: A preventive health strategy for sustainable aquaculture of tropical freshwater fish, Labeo rohita (Hamilton, 1822)

Gupta

Priyam

et al. 2021

Reviews in Aquaculture

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Dietary supplementation is an effective strategy for boosting the innate immune response in fishes. It involves the use of functional ingredients that bear the potential for mitigating the deleterious effects of chemotherapeutics (bioaccumulation and development of drug-resistant pathogens), as a more ecologically responsible approach to fish farming. With the emergence of probiotics, prebiotics, synbiotics and herbal immunostimulants; dietary supplementation has become an integral aspect of immunonutrition. In this review, we have compiled a list of dietary immunostimulants in rohu, based on the research carried over the last ten years. It should be noted that nearly 25% of the studies on dietary supplementation in Labeo rohita investigated probiotics species (either singly or as mixtures), followed by the use of herbal supplements or phytobiotics. In relation to stress, about 30% of the studies dealt with the supplementation of tryptophan, followed by the incorporation of lipotropes. Moreover, approximately 55-60% of the studies reviewed, were restricted to nutrition-based disease resistance against Aeromonas hydrophila infection. Commercially available probiotics and herbal feed additives have been helpful in the health management of L. rohita to some extent. Ongoing research is consistently exploring novel ingredients inducing favourable immunomodulation to survive stress and widespread A. hydrophila infection in L. rohita. However, further investigations aiming at broad-spectrum disease resistance and multiple stress resilience are recommended. Efforts must also be directed towards the elucidation of specifically targeted response in vivo. Overall, greater insights into the molecular mechanisms of dietary supplementation of immunostimulants warrants the use of downstream analytical techniques and highthroughput screening tools.

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“…Table S3: the relationship between supplementation to fish diet with growth, haematological parameters, blood performance, and immune system in fish meal replacement studies. References: [ 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 ] are cited in supplementary materials.…”

mentioning

confidence: 99%

Blood Performance: A New Formula for Fish Growth and Health

Esmaeili

2021

Biology

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Monitoring fish health in a repeatable and accurate manner can contribute to the profitability and sustainability of aquaculture. Haematological and blood biochemistry parameters have been powerful tools and becoming increasingly common in aquaculture studies. Fish growth is closely related to its health status. A fish with a higher growth rate is more likely to be a healthy one. Any change in the physiological status of the fish, from pollution to nutritional stress, can cause changes in the blood parameters. Various aquaculture studies have measured the following components: red blood cells, white blood cells, haemoglobin, haematocrit, and total protein. However, because these parameters do not always follow the same trend across experimental fish, it is difficult to draw a firm conclusion about which parameter should be considered. Therefore, Blood Performance (BP) as a new formula is introduced, which is a more reliable indicator. This formula is simple and sums up the natural logarithm of the five above-mentioned parameters. More than 90 published peer-reviewed articles that measured these five parameters in the last six years confirmed the reliability and validity of this formula. Regardless of which supplements were added to the diets, the fish with a higher growth rate had higher BP as well. In addition, in 44 studies out of 53 articles, there was a significant positive correlation between specific growth rate and BP. Under different stressful situations, from pollution to thermal stress, the fish under stress had a lower BP than the control. Fish meal and fish oil replacement studies were further evidence for this formula and showed that adding excessive alternative proteins decreased growth along with BP. In conclusion, BP can be a reliable indicator of fish health and growth when it is compared between groups in the same experiment or farm. Although there was a positive correlation between specific growth rate and BP, comparing BP between experiments is not recommended. Standardising the haematological assays can improve the reliability and accuracy of BP across experiments.

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Ameliorating effects of dietary mixture of Withania somnifera root extract and vitamin C in Labeo rohita against low pH and waterborne iron stresses

Cited by 18 publications

References 52 publications

Ethanolic root extract of Rauwolfia serpentina alleviates copper induced genotoxicity and hepatic impairments in spotted snakehead fish, Channa punctatus (Bloch, 1793)

Ethanolic root extract of Rauwolfia serpentina alleviates copper induced genotoxicity and hepatic impairments in spotted snakehead fish, Channa punctatus (Bloch, 1793)

Immunomodulation by dietary supplements: A preventive health strategy for sustainable aquaculture of tropical freshwater fish, Labeo rohita (Hamilton, 1822)

Blood Performance: A New Formula for Fish Growth and Health

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