Ameliorating Effects of Natural Antioxidant Compounds on Female Infertility: a Review

Bhardwaj, Jitender Kumar; Panchal, Harish; Saraf, Priyanka

doi:10.1007/s43032-020-00312-5

Cited by 46 publications

(27 citation statements)

References 336 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS can attack the cell membrane, causing poor sperm quality and male infertility [10,58,59]. Higher levels of ROS in obese mice have been shown to disturb the reproductive function of males through lipid peroxidation, testicular cell apoptosis, and sperm DNA fragmentation [60,61]. ROS attack sperm DNA and facilitate testicular apoptosis in a caspase-3-dependent manner [62].…”

Section: Discussionmentioning

confidence: 99%

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Dai

Luo

et al. 2021

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Background Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction. It has been reported that irisin, an exercise-induced myokine, may attenuate oxidative damage and testicular apoptosis in several diseases; however, its role in obesity-induced spermatogenesis dysfunction remains unclear. The purpose of this study was to investigate the role and underlying mechanism of irisin in obesity-induced dysfunction of spermatogenesis. Methods Male mice were fed a high-fat diet (HFD) for 24 weeks to establish a model of obesity-induced spermatogenesis dysfunction. To explore the effects of irisin, mice were subcutaneously infused with recombinant irisin for 8 weeks beginning at 16 weeks after starting a HFD. To confirm the role of AMP-activated protein kinase α (AMPKα), AMPKα-deficient mice were used. Results The data showed decreased serum irisin levels in obese patients, which was negatively correlated with sperm count and progressive motility. Irisin was downregulated in the plasma and testes of obese mice. Supplementation with irisin protected against HFD-induced spermatogenesis dysfunction and increased testosterone levels in mice. HFD-induced oxidative stress, endoplasmic reticulum (ER) stress and testicular apoptosis were largely attenuated by irisin treatment. Mechanistically, we identified that irisin activated the AMPKα signalling pathway. With AMPKα depletion, we found that the protective effects of irisin on spermatogenesis dysfunction were abolished in vivo and in vitro. Conclusions In conclusion, we found that irisin alleviated obesity-related spermatogenesis dysfunction via activation of the AMPKα signalling pathway. Based on these findings, we hypothesized that irisin is a potential therapeutic agent against obesity-related spermatogenesis dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Dai

Luo

et al. 2021

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…Oxidative stress can also lead to increased risk of threatened miscarriage, spontaneous abortion, recurrent pregnancy loss, and preeclampsia [123,124]. Antioxidant supplementation may be effective in controlling the production of ROS and combating damage caused by free radicals, and it continues to be explored as a potential strategy for overcoming pregnancy disorders associated with miscarriage [124].…”

Section: Nutritional Supplements In Threatened Miscarriagementioning

confidence: 99%

“…Antioxidant supplementation may be effective in controlling the production of ROS and combating damage caused by free radicals, and it continues to be explored as a potential strategy for overcoming pregnancy disorders associated with miscarriage [124]. Natural antioxidant compounds alone or in combination with other antioxidants or micronutrients during pregnancy may have the potential to prevent pregnancy loss and other complications [123]. Nutritional supplements and antioxidant intake are usually within the dietary reference intake range, which includes the effects of food and fortified foods, and only a few minor adverse events, such as gastrointestinal reactions, have been shown to occur [125].…”

Section: Nutritional Supplements In Threatened Miscarriagementioning

confidence: 99%

“…Oxidative stress has been recognized as one of the main mediators of female infertility by causing various reproductive pathologies such as polycystic ovary syndrome (PCOS), preeclampsia, miscarriage, and unexplained infertility [123]. When oxidative stress develops too early in pregnancy, it can impair placental development and/or enhance syncytiotrophoblastic degeneration, culminating in pregnancy loss [206].…”

Section: Other Antioxidantsmentioning

confidence: 99%

See 1 more Smart Citation

Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks

Zhou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Threatened miscarriage is one of the most common complications causing pregnancy loss, and it affects approximately 20% of confirmed pregnancies. More and more women are seeking treatment with complementary and alternative medicine (CAM) for this common complication, and it has been reported that women have had successful pregnancies after threatened miscarriage when being treated with CAM, which mainly includes Chinese herbal medicines, acupuncture, and nutritional supplements as well as psychological interventions and other approaches. However, many experts are concerned about the safety and adverse events of certain CAM approaches in women with threatened miscarriage. Therefore, this review focuses on the status of CAM for threatened miscarriage and presents the potential therapeutic efficacy and safety of CAM based on some clinical and experimental studies. We thus hope to provide some instructive suggestions for the application of CAM for treating threatened miscarriage in the future.

show abstract

“…Quercetin (Qcn) is a component of the polyphenolic group of compounds called flavonoids, found naturally in vegetables and fruits like onion, potatoes, apples, mulberry, broccoli, soybeans, peanuts, and red wine. It acts as a powerful antioxidant by scavenging the free radicals and chelation of transition metals (Bhardwaj et al ., 2020b; de Oliveira et al ., 2016). Several studies have shown the anti‐oxidative and cyto‐protective effects of Qcn in preventing the Cd‐induced oxidative stress and apoptosis both in vivo and in vitro in different organs (Wang et al ., 2018; Yuan et al ., 2016; Zargar et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Bhardwaj

Panchal

2021

Environ and Mol Mutagen

Self Cite

View full text Add to dashboard Cite

Cadmium (Cd), an environmental toxic heavy metal, has been reported to cause testicular toxicity, which contributes to the recent decline in male fertility worldwide. Quercetin (Qcn), a major dietary antioxidant, has been shown to have protective effects under various pathological conditions. However, whether Qcn provides protection against Cd‐stimulated testicular toxicity remains obscured. The present study was therefore aimed at investigating the ameliorative effect of Qcn supplementation on Cd‐induced toxicity in the goat testis in vitro in a dose‐(10, 50, and 100 μM) and time‐dependent (4 and 8 h) manner. Different cytotoxicity, genotoxicity, and biochemical analyses have been carried out using appropriate methods. Cytotoxicity in testicular cells induced by Cd treatment was apparently mitigated by Qcn treatment, evidenced by decreased apoptotic attributes or frequency in Qcn plus Cd‐treated groups compared to the only Cd‐treated groups. Qcn treatment provides substantial protection to the Cd‐triggered aggression in oxidative (increased MDA levels) and total antioxidant capacity (reduced FRAP activity) in testicular tissue, indicating the anti‐oxidative function of Qcn against Cd exposure. Moreover, Cd‐induced decline in antioxidant status (CAT, SOD, and GST activity) was markedly restored by Qcn supplementation in testicular tissue. In conclusion, this study shows that Qcn treatment significantly attenuated the Cd‐evoked testicular damage, suggesting its beneficial potential in preventing or at least in managing the gonadotoxicity in males induced by steadily increasing Cd contamination in the environment.

show abstract

Ameliorating Effects of Natural Antioxidant Compounds on Female Infertility: a Review

Cited by 46 publications

References 336 publications

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway

Complementary and Alternative Medicine for Threatened Miscarriage: Advantages and Risks

Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro

Contact Info

Product

Resources

About