Ameliorating effects of  Nigella sativa  oil on aggravation of inflammation, oxidative stress and cytotoxicity induced by smokeless tobacco extract in an allergic asthma model in Wistar rats

Khaldi, Taha; Chekchaki, N.; Boumendjel, Mahieddine; Taibi, Faiza; Abdellaoui, Mohamed; Messarah, Mahfoud; Boumendjel, Amel

doi:10.1016/j.aller.2018.02.005

Cited by 35 publications

(26 citation statements)

References 34 publications

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“…Similar findings are reported by Karaca and Eraslan (Karaca & Eraslan, 2013) and Pilar and others (Pilar et al, 2017). In fact , the body is able to produce endogenous antioxidants to reduce the damage caused by ROS, including GSH, Vit C and certain enzymes, such as SOD, CAT, GST and GPx (Khaldi et al, 2018). This thiol is abundant in living organisms in its reduced form (GSH).…”

Section: Discussionsupporting

confidence: 85%

Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

et al. 2020

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The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO.

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Section: Discussionsupporting

confidence: 85%

Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

et al. 2020

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“…The main difference between these studies is that liver enzymes were in normal range in our study, which might be the reason for detecting no significant reduction after intervention. Thymoquinone as an active ingredient of black seed has protective effects on oxidative stress in the liver cells, and it also improves the fatty acid beta‐oxidation and alleviates lipid accumulation in the liver (Balbaa, Abdulmalek, & Khalil, ; Hosseinian et al, ; Khaldi et al, ). One of the other mechanisms of thymoquinone in reducing levels of liver enzymes is improvement in the mitochondrial function and the production of ATP (Sayed‐Ahmed & Nagi, ).…”

Section: Discussionmentioning

confidence: 99%

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled clinical trial

Darand

Darabi

Yari

et al. 2019

Phytotherapy Research

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Nonalcoholic fatty liver disease (NAFLD) is highly related to cardiovascular disorders risk factors. This study aimed to evaluate the effects of black seed (Nigella sativa) supplementation on cardiovascular disorders risk factors in patients with NAFLD. This randomized, double‐blind, placebo‐controlled clinical trial was conducted on 50 patients with NAFLD. Participants were assigned to receive a lifestyle modification plus 2 g/day of either N. sativa or placebo for 12 weeks. Compared with the placebo, N. sativa supplementation led to significant reductions in serum glucose (−7.95 vs. −1.22; p = .041), serum insulin (−3.87 vs. −1.07; p = .027), homeostatic model of assessment for insulin resistance (−1.02 vs. −0.28; p = .021), and a significant increase in quantitative insulin sensitivity check index (0.03 vs. 0.006; p = .002). All of these changes were remained significant after adjusting for known confounding variables; however, there was no significant difference in lipid profile changes between the two groups (p = .05). N. sativa supplementation significantly decreased hepatic steatosis percentage compared with the placebo after adjustment for confounding variables (p = .005). In conclusion, our results indicate that daily intake of 2‐g N. sativa plus lifestyle modification is superior to lifestyle modification alone in amelioration of insulin resistance and hepatic steatosis in patients with NAFLD.

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“…Both Nigella sativa oil and thymoquinone are potent anti-inflammatory agents that have been demonstrated in various disease models such as encephalomyelitis, colitis, peritonitis, oedema and arthritis through suppression of inflammatory mediators such as prostaglandins and leukotrienes [7]. Orally gavage of 4 mL/kg/day Nigella sativa oil for 31 days showed a reduction of IL-4 and NO production in rats [8]. Thymoquinone at a dose of 10 mg/kg body weight of rats showed anti-inflammatory activity through inhibition of cyclooxygenase (COX) and 5-lipooxygenase (5-LPO) pathways [9,10] and at a dose of 5 mg/kg body weight of rats could lower TNF-α and IL-1β levels in arthritis [11].…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019

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Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

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Ameliorating effects of Nigella sativa oil on aggravation of inflammation, oxidative stress and cytotoxicity induced by smokeless tobacco extract in an allergic asthma model in Wistar rats

Abstract: Our data have proven that severe concurrent exposure to allergen and ST increases airway inflammation and oxidative stress in previously sensitized rats. They also suggest that the oral NSO treatment could be a promising treatment for asthma.

Cited by 35 publications

References 34 publications

Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled clinical trial

The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

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