Ameliorating effects of rosemary and costus on blood-associated toxicity in Ehrlich-bearing mice treated with cisplatin

Abstract

Background: Rosemary (ROLE) and costus (SLRE) have been established to show antioxidant effects. Aim: This study aimed to evaluate the ameliorating effects of ROLE and SLRE to the side-effects induced by cisplatin (CIS) in tumor-bearing mice. Materials and Methods: Extracts of ROLE and SLRE were examined for their phytochemical activities. To ecaluate their anti-tumor effects, mice were inoculated intraperitoneally (i.p.) with 2.5x10 5 Ehrlich ascites carcinoma (EAC) and then treated i.p. with CIS (dose????) at days 3-7 and with ROLE (dose) or SLRE (dose) at days 3-14. Mice were sacrificed on day 14 for CBC and T-cell analyses. Results: Phytochemical analysis revealed that both ROLE and SLRE showed similar antioxidant activities. Treatment of EAC-bearing mice with CIS induced antitumor efficacy of about 90%. Treatment with CIS in combination of ROLE or SLRE did not further enhance the the antitumor activity of CIS. However, co-administration of ROLE or SLRE with CIS increased significantly the antitumor efficacy of CIS. Flow cytometric analysis showed that the numbers of CD4 + and CD8 + T cells were decreased in EAC bearing mice after treatment with CIS. Treatment with both ROLE and SLRE improved the number of these cells. Conclusion: Combinatorial treatment with rosemary and costus can enhance the antitumor activity of CIS while lower its side effects.

Synergistic Antineoplastic and Immunomodulatory Effects of Hesperidin in Ehrlich Ascites Carcinoma Tumor Model Treated with Cisplatin

“…Within the scope of this study, flow cytometric analysis showed that HDN combined treatment with Cis induced an antitumor immune response by increasing the percentage of splenic T helper (CD3 + CD4 + ) and T cytotoxic (CD3 + CD8 + ) cells, while concurrently orchestrating a modulatory effect on CD4 + CD25 + regulatory cells accompanied by improving spleen proliferation, which regulate the immune response against tumor. Similarly, earlier investigations revealed the synergistic role of combined treatments with Cis on antitumor immunity (Ye et al, 2018;El-Bolkiny et al, 2021;Wang et al, 2022). Hassouna et al (2015) and Berköz et al (2021) documented that HDN can improve the immunosuppressive impact of diazinon and cyclophosphamide, respectively.…”

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“…Within the scope of this study, flow cytometric analysis showed that HDN combined treatment with Cis induced an antitumor immune response by increasing the percentage of splenic T helper (CD3 + CD4 + ) and T cytotoxic (CD3 + CD8 + ) cells, while concurrently orchestrating a modulatory effect on CD4 + CD25 + regulatory cells accompanied by improving spleen proliferation, which regulate the immune response against tumor. Similarly, earlier investigations revealed the synergistic role of combined treatments with Cis on antitumor immunity (Ye et al, 2018;El-Bolkiny et al, 2021;. Hassouna et al (2015) and Berköz et al (2021) documented that HDN can improve the immunosuppressive impact of diazinon and cyclophosphamide, respectively.…”

“…On the contrary, combined treatment with (HDN and Cis) improved these hematological alterations, hepatorenal toxicity, and oxidative stress toward normal values. Previous studies have reported toxic effects of Cis on bone marrow cell colonies that substantially affect blood cells and induce hematotoxicity (Das et al, 2003;Aldossary 2019;Ibrahim et al, 2020;El-Bolkiny et al, 2021).…”

Potential Ameliorative Effect of Propolis Against the Developmental Toxicity Induced by Oxaliplatin in Albino Rats Prior and During Pregnancy

“…Not only cancer is a public health disease, but also may have profound implications for immune defense [28] . However, chemotherapy used for cancer treatment has associated with varying profound side effects [2] . OXA, cisplatin, and carboplatin are the major platinum compound used in cancer chemotherapy [29] .…”

“…Cancer is the most common chronic disease; the information about the occurrence and the possibility of cancer therapy during pregnancy is increasing nowadays [1] . A variety of theses chemotherapeutic drugs was in a concomitant with significant toxic manifestations [2] . The kidney is crucial organ for the major function of the body.…”