Amélioration de la réinnervation musculaire par utilisation de colle biologique enrichie chez le rat

Daunois, O.; Sebille, Alain

doi:10.1016/s0753-9053(05)80189-9

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1995

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“…Esta observação levou muitos autores a estudar a regeneração nervosa através de adesivos biológicos (Cooper & Falb, 1968;Boedts & Boukaert, 1984;Boedts, 1987;Moy et al, 1988;Nishihira & McCafrey, 1989;Jin et al, 1990;Daunois & Sébille, 1991;Bertelli & Mira, 1993).…”

Section: Introductionunclassified

Estudo comparativo com diferentes números de pontes na neurorrafia término-lateral em ratos

Franco¹

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Section: Introductionunclassified

Estudo comparativo com diferentes números de pontes na neurorrafia término-lateral em ratos

Franco¹

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The effect of glial cell line-derived neurotrophic factor in fibrin glue on developing dopamine neurons

et al. 1995

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Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-beta superfamily, promotes the survival, morphological differentiation, and high-affinity dopamine (DA) uptake of cultured nigral DA neurons. In order to test potential methodology for peptide delivery in vivo, GDNF-containing fibrin glue balls (8 micrograms/ball) were incorporated with pieces of fetal ventral mesencephalon (E15) and transplanted into the anterior chambers of sympathetically denervated adult rats. Five weeks after grafting, the numbers of TH-positive neurons and the nerve fiber density were significantly higher in the ventral mesencephalic grafts treated with GDNF-containing glue balls than in those treated with vehicle. In addition, the laminin and GFAP immunoreactivities were similar between the two groups. These data support the concept that GDNF is a potent trophic factor for DA neurons in vivo and suggest that fibrin glue may provide a unique and safe means to permit prolonged delivery of trophic molecules to CNS tissues.

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Amélioration de la réinnervation musculaire par utilisation de colle biologique enrichie chez le rat

Cited by 2 publications

References 13 publications

Estudo comparativo com diferentes números de pontes na neurorrafia término-lateral em ratos

Estudo comparativo com diferentes números de pontes na neurorrafia término-lateral em ratos

The effect of glial cell line-derived neurotrophic factor in fibrin glue on developing dopamine neurons

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