Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs

Vaagenes, Per; Cantadore, Rinaldo; Šafář, Peter; Moossy, John; Rao, Gutti R.; Diven, Warren F.; Alexander, Henry; Stezoski, William

doi:10.1097/00003246-198410000-00002

Cited by 167 publications

(38 citation statements)

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“…Neurological function was assessed quantitatively, as described by Bircher, Safar, Vaagenes, and colleagues. 8,9 The Swine Neurologic Deficit Score was used to evaluate level of consciousness, respiratory pattern, cranial nerve function, motor and sensory function, and behavior evaluation, including ability to drink, chew, stand, and walk. 8 The Cerebral Performance Score was also used.…”

Section: Protocolmentioning

confidence: 99%

Use of an Inspiratory Impedance Valve Improves Neurologically Intact Survival in a Porcine Model of Ventricular Fibrillation

et al. 2002

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Section: Protocolmentioning

confidence: 99%

Use of an Inspiratory Impedance Valve Improves Neurologically Intact Survival in a Porcine Model of Ventricular Fibrillation

et al. 2002

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“…6 Recently, potent, highly selective inhibitors of thromboxane synthetase, the enzyme that produces TxA 2 from the cyclic endoperoxide products of cyclo-oxygenase, have been developed and tested in animals and man. 17 ' ' 8 In addition to inhibiting the production of TxA 2 , thromboxane synthetase inhibitors also lead to an increased production of PGI 2 . 17 We undertook a study of global brain ischemia in a canine model to determine whether the thromboxane synthetase inhibitor UK 38,485 (dazmagrel) decreases the release of TxA 2 and increases the release of PGI 2 , thereby increasing cerebral blood flow following global brain ischemia.…”

mentioning

confidence: 99%

Inhibition of thromboxane A2 production does not improve post-ischemic brain hypoperfusion in the dog.

Prough

Kong²,

Watkins³

et al. 1986

Stroke

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SUMMARY In a canine model of global brain ischemia, six dogs received a selective thromboxane A 2 synthetase inhibitor, UK 38,485 (dazmagrel) before the ischemic event; six received a saline placebo. Cerebral blood flow (CBF), systolic and diastolic arterial pressure, cardiac output, pH, PaCO 2 , PaO 2 , and arterial and jugular-vein thromboxane B 2 (a stable metabolite of thromboxane Aj) and 6-keto PGF ln (a stable metabolite of prostacyclin) were measured at baseline, after release of aortic and venae caval occlusion and at intervals up to 120 min thereafter. Treated animals showed nearly complete post-ischemic inhibition of thromboxane B 2 production; control animals showed increases in jugular venous thromboxane B 2 . Arterial and jugular venous levels of 6-keto PGF, a were significantly higher in treated animals at most post-ischemic intervals. CBF in both groups was similar to baseline values at tune 0, then declined similarly in both groups by 30 min to ^35% of baseline values where it remained thereafter. There were no significant differences in other variables at any interval. We conclude that inhibition of thromboxane A 2 production does not alter post-ischemic brain hypoperfusion.

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“…Severe asphyxia was instituted in I I cases, six in the treatment group (mean time to asystole 16.3 min. range 12.5-20 min) and five in the control group (mean time to asystole 13.0 rnin, range [10][11][12][13][14][15][16][17][18][19][20]. The moderate asphyxia group consisted of 15 cases, eight in the treatment and seven in the control group.…”

Section: Methodsmentioning

confidence: 99%

“…Lidoflazine was used because its documented effect for protection against postasphyctic cerebral damage in adult animals (20).…”

Section: S T a R T Resuscitation Minutesmentioning

confidence: 99%

Postasphyxial Cerebral Survival in Newborn Sheep after Treatment with Oxygen Free Radical Scavengers and a Calcium Antagonist

Thiringer

Karlsson

et al. 1987

Pediatr Res

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ABSTRACT. Acute, severe intrapartum asphyxia was mimicked by tying the umbilical cord in the exteriorized fetal sheep. After a standard time period cardiopulmonary resuscitation was instituted. In the treatment group (n = 14) the lzmbs were given a composition of scavengers of oxygen-derived free radicals and a calcium channel blocker.The control group of lambs (n = 12) was given placebo.The trial was blind and randomized. Hemodynamic and neurophysiological variables were measured from 30 min before asphyxia to 2 h postresuscitation. Mean arterial blood pressure, sagittal sinus venous pressure, heart rate, and cardiac output did not differ between the two grouDs -m although dramaiic changes took place during asphyxia and resuscitation. Cerebral blood flow measured bv 133-Xe

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Amelioration of brain damage by lidoflazine after prolonged ventricular fibrillation cardiac arrest in dogs

Cited by 167 publications

References 0 publications

Use of an Inspiratory Impedance Valve Improves Neurologically Intact Survival in a Porcine Model of Ventricular Fibrillation

Use of an Inspiratory Impedance Valve Improves Neurologically Intact Survival in a Porcine Model of Ventricular Fibrillation

Inhibition of thromboxane A2 production does not improve post-ischemic brain hypoperfusion in the dog.

Postasphyxial Cerebral Survival in Newborn Sheep after Treatment with Oxygen Free Radical Scavengers and a Calcium Antagonist

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