Amelioration of cisplatin induced nephrotoxicity by PTY: A herbal preparation

Nagwani, Santosh; Tripathi, Yamini B.

doi:10.1016/j.fct.2010.05.057

Cited by 27 publications

(24 citation statements)

References 39 publications

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“…Among these, various compounds of herbal origin have been tested (Nagwani and Tripathi, 2010;Nitha and Janardhanan, 2008;Sohn et al, 2009a, b). These are notably issued from traditional Chinese medicine remedies that benefit from long-term use probably justifying their safety.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro

Bunel

Antoine

Nortier

et al. 2013

J of Applied Toxicology

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Renal proximal tubular epithelial cells are the main targets of toxic drugs such as cisplatin (CisPt), an alkylating agent indicated for the treatment of solid organ tumors. Current techniques aiming at reducing nephrotoxicity in patients receiving CisPt are still not satisfactory as they can only partially prevent acute kidney injury. New nephroprotective strategies remain to be developed. In the present in vitro study, schizandrin (Schi) and schizandrin B (Schi B), major phytochemicals from Schisandra chinensis (Turcz.) Baill. fruits, were tested on HK-2 cells along four processes that could help alleviate CisPt toxicity. Results indicated that: (i) both Schi and Schi B enhanced cell survival via reducing apoptosis rate; (ii) only Schi showed moderate effects towards modulation of regeneration capacities of healthy cells; (iii) both Schi and Schi B limited extracellular matrix deposition; and (iv) both compounds could help preventing dedifferentiation processes via the β-catenin pathway. Schi and Schi B present promising activities for future development of protective agents against CisPt nephrotoxicity.

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Section: Introductionmentioning

confidence: 99%

Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro

Bunel

Antoine

Nortier

et al. 2013

J of Applied Toxicology

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“…These pharmacological approaches have mainly focused on discovering compounds of natural origin (Nagwani & Tripathi, 2010;Nitha & Janardhanan, 2008;Sohn et al, 2009), notably issuing from Traditional Chinese Medicine (TCM) remedies.…”

Section: Introductionmentioning

confidence: 99%

Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

Bunel

Antoine

Nortier

et al. 2014

Pharmaceutical Biology

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Context: Acute kidney injury (AKI) is often encountered in patients receiving cisplatin (CisPt), a chemotherapeutic drug that induces numerous toxic side effects. Techniques used to limit nephrotoxicity during CisPt treatment are not fully effective; about a third of patients experience AKI. New nephroprotective strategies, including pharmacological approaches, must be developed. Objective: The present study investigated the nephroprotective potential of Angelica sinensis (Oliv.) Diels (Apiaceae) root towards CisPt tubulotoxicity. Materials and methods: HK-2 cells were incubated with CisPt (10 mM) and/or with a methanolic extract of A. sinensis (AS). Nephroprotective capacity was evaluated by means of cellular viability (resazurin assay) and apoptosis (annexin-V/PI staining), oxidative stress generation (H 2 DCF-DA oxidation), Ki-67 index (immunofluorescence), cell cycle analysis (DNA staining), cell migration rate (scratch assay), extracellular matrix deposition (collagen determination), and b-catenin relocalization. Results: CisPt decreased cell viability [76% versus Ctrl], which was associated with an increased apoptosis. Simultaneous treatment with 50 mg/ml AS enhanced cell survival [84% versus Ctrl] and decreased the apoptosis rate. AS could not alleviate CisPt-induced oxidative stress; but doses of 5 and 50 mg/ml raised the Ki-67 index [135 and 244% versus Ctrl] and cell migration rates [1.2 and 1.3-fold versus Ctrl]. Finally, both doses of AS limited the amount of collagen deposition [121.6 and 119.6% for 5 and 50 mg/ml, respectively, versus 131.0% for CisPt-treated cells] and prevented the relocalization of b-catenin from the membrane to the nucleus. Conclusion: These results confirm the nephroprotective potential of A. sinensis and require further investigations aiming at identifying its active compounds.

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“…The oxidative conversion of 3,9-dimethoxypterocarpan (11) to 3, 9-dimethoxypterocarpan-6a-ol (12) is carried out using lead tetra acetate-aqueous acetic acid. The conversion of tuberosin (6) to yield 1a-hydroxytuberosone (7) is achieved from sodium periodate after many attempts with Fremy'salt, thallium(III) triperchlorate, and thallium (III) triflouro acetate were unsuccessful to produce the desired compound, (7). The further transformations to 3-O-methyldeoxytuberosin (4a) from deoxytuberosin (4), 3-O-methylanhydrotuberosin (8a) from anhydrotuberosin (8) and vice versa (8a to 8) is mimicked using methyl iodide for the methylation step in an analogy to the biogenesis of 3-O-methylpterocarpan and 3-O-methylpterocarpene from pterocarpan and pterocarpene, whereas boron tribromide [59] (Hazard!)…”

Section: Resultsmentioning

confidence: 99%

“…To the isoflavan-4-ol dissolved in dichloromethane (20 mL) was added glacial acetic acid (1.0 mL) and RM refluxed at water bath for 1 h. Solvent evaporated under vacuum to yield a solid, which was PLC purified to give deoxytuberosin (4) Tuberosin (6) to 1a-hydroxytuberosone (7). To tuberosin (6, 30 mg), excess sodium periodate (20 mg) in water (50 mL) was added and stirred for 10 h. The light-brown mixture evaporated to 1/3 volume, extracted with diethyl ether (2 Â 25 mL), dried over anhydrous sodium sulfate and concentrated to an oily mass, which was purified by PLC to give 1a-hydroxytuberosone, identical to natural sample (7,22 1a-Hydroxytuberosone (7) to tuberosin (6). A mixture of 1a-hydroxytuberosone (7, 10 mg), Zn-dust (20 mg) and glacial acetic acid (4.0 mL) was vigorously stirred at RT for 2 h and 3-O-Methylanhydrotuberosin (8a) to anhydrotuberosin (8).…”

Section: Methodsmentioning

confidence: 99%

“…The plants and their parts have been found to possess wide spectrum of biological activities including protection against stress-induced myocardial ischemia, nootropic activity, helpful in ameliorating conditions of migraine and deafness, antioxidant properties, dose-dependent hepatotoxicity, antimicrobial properties [6][7][8][9][10], uses in estrogen replacement therapies, an emergency food and as a food supplement [11][12][13][14][15]. The isoflavonoids play significant roles in plant-microbe interactions at biology-environment interface [16,17] and are considered to be involved in signal transductions [18][19][20], contributions to root-nodules formation in leguminous plants [21][22][23] and their functions as plant antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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An enzyme‐mimetic chemical conversion and biogenetic outline for chemical marker pterocarponoid oxygen heterocycles from Kudzu vine

Khan

2010

Journal of Heterocyclic Chem

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An enzymatic chemical conversion of isoflavone and chemical marker oxygen‐heterocycles pterocarponoids are carried out in an analogy to major subcellular enzymatic conversions involved in the natural biogenetic pathway and microbial interaction steps for oxygen‐proliferated products obtained from bioactive fractions of widely occurring Kudzu plant, Pueraria tuberosa. An outline for biogenesis of major pterocarponoid constituents from principal biogenetic precursor, deoxytuberosin, is also proposed for P tuberosa. J. Heterocyclic Chem., (2010).

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Amelioration of cisplatin induced nephrotoxicity by PTY: A herbal preparation

Cited by 27 publications

References 39 publications

Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro

Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro

Potential nephroprotective effects of the Chinese herbAngelica sinensisagainst cisplatin tubulotoxicity

An enzyme‐mimetic chemical conversion and biogenetic outline for chemical marker pterocarponoid oxygen heterocycles from Kudzu vine

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