2019
DOI: 10.3390/ijms20143485
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Amelioration of Enterotoxigenic Escherichia coli-Induced Intestinal Barrier Disruption by Low-Molecular-Weight Chitosan in Weaned Pigs is Related to Suppressed Intestinal Inflammation and Apoptosis

Abstract: Enterotoxigenic Escherichia coli (ETEC) infection destroys the intestinal barrier integrity, in turn, disrupting intestinal homoeostasis. Low-molecular-weight chitosan (LMWC) is a water-soluble chitosan derivative with versatile biological properties. Herein, we examined whether LMWC could relieve ETEC-induced intestinal barrier damage in weaned pigs. Twenty-four weaned pigs were allotted to three treatments: (1) non-infected control; (2) ETEC-infected control; and (3) ETEC infection + LMWC supplementation (10… Show more

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Cited by 34 publications
(28 citation statements)
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“…However, excessive production of Proinflammatory cytokine might lead to body and gut damage [60]. As expected, ETEC challenge significantly elevated the expression levels of critical inflammatory response genes such as the IL-1β, IL-6, and TNF-α in the intestine, which was consistent with the previous reports [61,62]. However, their expression levels were significantly down-regulated by BMGlvA2.…”
Section: Discussionsupporting
confidence: 90%
“…However, excessive production of Proinflammatory cytokine might lead to body and gut damage [60]. As expected, ETEC challenge significantly elevated the expression levels of critical inflammatory response genes such as the IL-1β, IL-6, and TNF-α in the intestine, which was consistent with the previous reports [61,62]. However, their expression levels were significantly down-regulated by BMGlvA2.…”
Section: Discussionsupporting
confidence: 90%
“…In the present study, ETEC challenge significantly elevated the expression levels of inflammatory cytokines such as the IL-1β and TNF-α in the IPEC-J2 cells, which was consistent with previous studies using the same cell line [34,35]. ETEC activates the innate immune system of host cells, producing pro-inflammatory and chemokines [36,37].…”
Section: Discussionsupporting
confidence: 93%
“…Meanwhile, both LPS and capsaicin treatment did not significantly affect the protein expression of OCLN. One potential reason why capsaicin is able to improve barrier integrity under the LPS stimulation could be attributed to the anti-inflammation property of capsaicin, given that cytokines have been documented to have participated in the regulation of intestinal barrier integrity (Wan et al, 2019). There is evidence that cytokines lead to the disruption of intestinal barrier integrity, contributing to a further increase in tight junction permeability.…”
Section: Discussionmentioning
confidence: 99%