Amelioration of high-fat diet-induced obesity and its associated complications by a myricetin derivative-rich fraction from <i>Syzygium malaccense</i> in C57BL/6J mice

Nallappan, Devi; Chua, Kek Heng; Ong, Kien Chai; Chong, Chun Wie; Teh, Cindy Shuan Ju; Palanisamy, Uma Devi; Kuppusamy, Umah Rani

doi:10.1039/d1fo00539a

Cited by 11 publications

(1 citation statement)

References 84 publications

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“…Myricetin inhibited the absorption of ox‐LDL by CD36 in macrophage foam cells, indicating that myricetin may have a significant therapeutic role in AS (Meng et al, 2019). Myricetin may enhance the number of the Akkermansia genus and uncoupling protein‐1 (UCP‐1), which indicates improved metabolic status, as well as reduce obesity and its associated complications (Nallappan et al, 2021).…”

Section: Flavonoidsmentioning

confidence: 99%

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Zhou

Zhao

et al. 2022

Journal of Food Biochemistry

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Coronary heart disease (CHD) is defined by atherosclerosis, which can result in stenosis or blockage of the arterial cavity, leading to ischemic cardiac diseases such as angina and myocardial infarction. Accumulating evidence indicates that the gut microbiota plays a vital role in the beginning and progression of CHD. The gut microbial metabolite, trimethylamine‐N‐oxide (TMAO), is intimately linked to the pathophysiology of CHD. TMAO is formed when trimethylamine (TMA) is converted by flavin‐containing monooxygenases in the hepatocytes. Therefore, inhibition of TMA production is essential to reduce TMAO levels. Flavonoids may reduce the risk of death from cardiovascular disease. In this article, we reviewed and evaluated twenty‐two flavonoids for the therapy of CHD based on their inhibition of TMA‐lyase by molecular docking. Docking results revealed that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin, and hesperidin in flavonoid glycosides had a good binding effect with TMA‐lyase. This indicates that these chemicals were the most active and could be used as lead compounds for structural modification in the future. Practical applications Flavonoids are a large class of polyphenolic compounds found in fruits, vegetables, flowers, tea, and herbal medicines, which are inexorably metabolized and transformed into bioactive metabolites by α‐rhamnosidase, β‐glucuronidase, β‐glucosidase, and nitroreductase produced by the gut microbiota, which plays a beneficial role in the prevention and treatment of cardiovascular diseases. Because flavonoids protect the cardiovascular system and regulate the gut microbiota, and the gut microbiota is directly connected to TMAO, thus, reducing TMAO levels involves blocking the transition of TMA to TMAO, which may be performed by reducing TMA synthesis. Molecular docking results found that baicalein, fisetin, acacetin, and myricetin in flavonoid aglycones, and baicalin, naringin, and hesperidin in flavonoid glycosides had good binding effects on TMA‐lyase, which were the most active and could be used as lead compounds for structural modification.

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Section: Flavonoidsmentioning

confidence: 99%

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Zhou

Zhao

et al. 2022

Journal of Food Biochemistry

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Structural insights and biological activities of flavonoids: Implications for novel applications

Tang,

Wang,

Liu

et al. 2024

Food Frontiers

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Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering considerable attention. Notably, the physicochemical properties and functionalities of flavonoids are structurally dependent. Variations in chemical structure lead to differences in physicochemical characteristics among different flavonoid types. Structural alterations can modify these characteristics, influencing biological activities and mechanisms of action. However, these structural variations and their biological implication have not been comprehensively elucidated. In this review, we outline the structural characteristics of flavonoids, discuss biosynthesis, in vivo digestion, and absorption, and particularly emphasize the diverse biological activities and action mechanisms associated with different flavonoid structures. By summarizing the current scientific findings, we aim to elucidate the structure–activity relationships of flavonoids and provide a theoretical basis for the development of new flavonoid applications, which will help to target the design of functional molecules and moieties in the food and pharmaceutical industries for use in drug design and development.Practical Application: Understanding the structural characteristics and biological activities of flavonoids can guide the development of functional food products and dietary supplements with targeted health benefits. By leveraging the knowledge of flavonoid structure–activity relationships, food, and pharmaceutical industries can innovate formulations to enhance bioavailability and efficacy, potentially leading to the creation of tailored products for specific health conditions or dietary needs. This research lays the groundwork for the design of novel flavonoid‐based interventions aimed at promoting human health and well‐being.

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Novel plant bioactives, their antiaging potencies: reality and promises

Kuppusamy

Arumugam

2023

Plant Bioactives as Natural Panacea Against Age-Induced Diseases

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Amelioration of high-fat diet-induced obesity and its associated complications by a myricetin derivative-rich fraction from Syzygium malaccense in C57BL/6J mice

Abstract: S. malaccense myricetin derivatives reverse high-fat diet-induced obesity-associated metabolic complications by upregulating UCP-1 and increasing the abundance of gut Akkermansia.

Cited by 11 publications

References 84 publications

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Virtual screening analysis of natural flavonoids as trimethylamine ( TMA )‐lyase inhibitors for coronary heart disease

Structural insights and biological activities of flavonoids: Implications for novel applications

Novel plant bioactives, their antiaging potencies: reality and promises

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