Amelioration of lead- and cadmium-induced rat tracheal hypercontraction by linalool and eugenol

Shabir, Hiba; Kundu, Swati; Basir, Seemi Farhat; Khan, Luqman Ahmad

doi:10.1080/02772248.2014.931520

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Increased inhibition of contraction seen when verapamil was co-incubated with eugenol points to different site of action of these two molecules. We have also observed similar antioxidant effects of eugenol in the tracheal system (14). These results are in line with those suggesting that eugenol exerts cardiopreventive effects through its antioxidant properties (29), while a calcium antagonist action of eugenol has also been observed, but at higher concentrations (10).…”

Section: Discussionsupporting

confidence: 71%

“…These active principles are reported to show relaxation effect on the cardiovascular system (10-12). The relaxant effects of eugenol and linalool on both the aorta and trachea has been shown in our previous work (13, 14). Additionally, the calcium-dependent and calcium-independent inhibitory effect of eugenol has also been reported on various smooth muscle tissues (10, 15).…”

Section: Introductionsupporting

confidence: 65%

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Inhibition of As(III) and Hg(II) caused aortic hypercontraction by eugenol, linalool and carvone

Kundu

Shabir

Basir

et al. 2014

J. Smooth Muscle Res.

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Acute and chronic exposure to arsenic and mercury is known to produce vasoconstriction. There is, however, no clarity concerning the pathways leading to this increased contraction. In this study we elicit and compare maximum contractility of rat aortas under resting conditions in the presence of arsenic and mercury, and delineate pathways mediating this effect. Phenylephrine (PE) induced hypercontraction of 37% and 32% were obtained when isolated aortic segments were exposed to 25 µM As(III) and 6 nM Hg(II), respectively. Isometric contraction measurements in presence of apocynin, verapamil and sodium nitroprusside indicates that the major causes of increased contraction are reactive oxygen species (ROS) and depletion of nitric oxide (NO). Calcium influx plays a minor role in arsenic and mercury caused hypercontraction. In unexposed aorta, eugenol causes relaxation by inhibiting ROS and elevating NO, linalool by blocking voltage dependent calcium channel (VDCC) and elevating NO, and carvone by blocking calcium influx through VDDC. Since the arsenic and mercury hypercontraction is mediated by increased ROS and depleted NO, we hypothesize that molecules which neutralize ROS or elevate NO will be better ameliorators. In line with this argument, we found eugenol to be the best ameliorator of arsenic and mercury hypercontraction followed by linalool and carvone.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionsupporting

confidence: 65%

Inhibition of As(III) and Hg(II) caused aortic hypercontraction by eugenol, linalool and carvone

Kundu

Shabir

Basir

et al. 2014

J. Smooth Muscle Res.

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“…Linalool and eugenol, the constituents of O. basilicum , were also shown to have a relaxing effect on TSM or a bronchodilator effect similar to the plant itself ( Shabir et al, 2014 ; Silveira et al, 2017 ). The relaxation effects of eugenol and linalool (100 mM) on TSM in the absence and presence of three inhibitors indicated that the main mechanism responsible for the relaxant effect of linalool is its inhibitory effect on cyclooxygenase signaling cascades, and that for eugenol is its ROS inhibitory effect.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.

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Elucidation of Mechanisms in Cu (II) Caused Hypercontraction of Rat Tracheal Rings

Afrin

Basir

Khan

2021

Biol Trace Elem Res

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Amelioration of lead- and cadmium-induced rat tracheal hypercontraction by linalool and eugenol

Cited by 5 publications

References 35 publications

Inhibition of As(III) and Hg(II) caused aortic hypercontraction by eugenol, linalool and carvone

Inhibition of As(III) and Hg(II) caused aortic hypercontraction by eugenol, linalool and carvone

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

Elucidation of Mechanisms in Cu (II) Caused Hypercontraction of Rat Tracheal Rings

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