Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats

Abstract

Aim: Alcoholism leads to heart diseases, lung diseases and liver disorders. Alcoholism impairs heart homeostasis and causes cardio vascular diseases. The current investigation was carried out to know the hypolipidemic effect of Trigonelline (TG) a bioactive compound of Trigonella foenum-graecum (TGf ) in alcohol intoxicated rats. Materials and Methods: The rats were randomized into five groups and treatment was given as per the experimental protocol. The lipid metabolic profiles like Malondialdehyde (MDA), Total Cholesterol (TC), Triglycerides (TGs), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Very-Low-Density Lipoprotein (VLDL), and liver markers Alkaline Phosphatase (ALP), Alanine Aminotransferase (AAT), Aspartate Aminotransferase (AST) were estimated in the serum of all experimental groups. Results: All the lipid metabolic profiles and AAT, AST, ALP elevated in alcohol treated group, except HDL. This may be due to the alterations in lipid metabolism, which leads to hypercholesterolaemia and alcohol induced liver damage. Whereas with trigonelline treatment in alcoholic rats, these lipid metabolic profiles and liver markers were normalized and came back to normal levels. Further histopathological observations also proved that trigonelline protected heart tissue from alcohol toxicity in rats. Conclusion: Our findings suggest that trigonelline modulated the lipid metabolic profiles in alcohol intoxicated rats, hence trigonelline might be effective for preventing or treating alcohol related disorders and lipid related diseases.

Nutraceutical activities of Trigonella foenum‐graecum and Nigella sativa seeds in the management of diabetes‐induced in albino rats

“…Studies revealed that FS and BCS contain ample amounts of bioactive ingredients that strengthen their anti-diabetic potential by acting as strong antioxidants. Our results agree with the findings that FSs and BCSs possess beta-carotene, chlorogenic acid, caffeic acid, kaempferol, thymoquinone, saponins, and diosgenin (Hannan et al, 2007;Hameed et al, 2019;Laila et al, 2023;Sekhar et al, 2024). Our findings of antioxidants are correlated with the findings of Aslam et al (2024), who found that the antioxidant potential measured by DPPH scavenging activity and ferric-reducing activity is directly related to the concentration of BCS.…”

“…Cholesterol levels of groups T3-T5 were reduced at the end of the study through the supplementation of FS and BCS. The current study showed a resemblance with the literature study performed by Chalabi et al (2019) and Sekhar et al (2024), in which diabetic group exhibited a significant decline (p < 0.05) in total cholesterol (TC) level treated with T. foenum gracum for 42 days in a dose-dependent manner. However, for N. sativa seeds, study findings were consistent with the study (Al-Logmani & Zari, 2011), in which BCS significantly (p < 0.001) increased levels of HDL-cholesterol and significantly (p < 0.001) reduced LDL-cholesterol in streptozotocin-induced diabetic models.…”