Amelioration of Lung Ischemic Injury With Prostacyclin

Hooper, Timothy L.; Thomson, D. S.; Jones, Mark T.; Cook, Lawrence; Owen, Stephen; Wilkes, Susan; Woodcock, Ashley; Webster, Alan H.; Hasleton, Philip; Campbell, Colin; Rahman, A; McGregor, Christopher G.A.

doi:10.1097/00007890-199006000-00001

Cited by 43 publications

(22 citation statements)

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“…14,15 It is also involved in the amplification of antiplatelet fibrinolytic activity and the inhibition of platelet and leukocyte aggregation. [16][17][18] The clinical benefits of PGE1 in hepatic surgery are well documented. It has been reported that PGE1 prevents hepatocellular damage after hepatectomy, [19][20][21] and recent randomized prospective studies in liver transplantation have also shown that PGE1 decreases postoperative morbidity and shortens hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Prostaglandin E1 Treatment for the Prevention of Postoperative Complications After Esophagectomy: A Randomized Clinical Trial

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Perioperative Prostaglandin E1 Treatment for the Prevention of Postoperative Complications After Esophagectomy: A Randomized Clinical Trial

et al. 2004

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“…Prostaglandins have also other properties (inhibition of platelet aggregation and leuko-Vainikka/Heikkilä/Kukkonen/ Toivonen/Verkkala/Mattila cyte sequestration in damaged tissue, prevention of lysosomal enzyme release and superoxide anion production by neutrophils), which might be of theoretical benefit in protecting against ischemia reperfusion injury [9][10][11]. A direct cytoprotective effect of prostaglandins was suggested to account for improvement of early graft function by mitigating vascular permeability [12,13].…”

Section: Discussionmentioning

confidence: 99%

Donor Lung Pretreatment with Prostaglandin E<sub>1</sub> Does Not Improve Lung Graft Preservation

Vainikka

Heikkilä²,

Kukkonen³

et al. 1999

Eur Surg Res

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Prostaglandin E₁ (PGE₁) is widely used to improve early graft function after lung transplantation, but some studies have questioned its benefits. Therefore we evaluated the effect of donor pretreatment with PGE₁ in our porcine model of single lung transplantation. Donors received PGE₁ or placebo intravenously before flushing the pulmonary artery with modified Euro-Collins solution. After cold storage, the excised left lung was transplanted. Ischemic time was 4 h. We used our right side heart bypass model to measure standardized pulmonary vascular resistance and to study blood flow distribution between recipient’s native and transplanted lung. Systemic and pulmonary hemodynamics and gas exchange were also measured. After transplantation, pulmonary vascular resistance was significantly higher in the transplanted lung, which received only one fourth of the total pulmonary blood flow. PGE₁ pretreatment did not improve pulmonary hemodynamic parameters, or gas exchange.

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“…However, hypertonic citrate solution has been shown to significantly reduce reperfusion injury and neutrophil sequestration in canine lungs following 60 min of warm ischemia [28]. Although the formulations of CS-4 and hypertonic citrate solution differ, the presence of citrate or citric acid may have pro vided a benefit either via the citric acid cycle, or by inhib iting C-reactive protein binding to leukocytes [29].…”

Section: Discussionmentioning

confidence: 99%

Effect of Superoxide Dismutase and 21-Aminosteroids (Lazaroids) on Microvascular Perfusion following Ischemia-Reperfusion in Skeletal Muscle

Potter

Ellis²,

Tyml³

et al. 1994

Int J Microcirc

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Intravital video microscopy was used to test superoxide dismutase and a lazaroid analogue, U-74389F, as a pretreatment for ischemia-reperfusion-induced microvascular dysfunction in skeletal muscle. Twenty-two male Wistar rats (350-400 g), anesthetized with sodium pentobarbital (65 mg/kg i.p.), were divided into groups to test the lazaroid analogue U-74389F (3 mg/kg; n = 8), a citric acid/citrate mixture (CS-4; n = 4) used as the vehicle for the lazaroid analogue, superoxide dismutase (SOD, 10 mg/kg; n = 5), and saline (n = 5). Normothermic ischemia of the extensor digitorum longus muscle was induced for 3 h by tightening a tourniquet placed around the limb above the muscle. Measurements of the number of perfused capillaries (CD_per; mm^-1) and capillary red blood cell velocity (V_RBC; mm/s) were made after 30,60 and 90 min of reperfusion. Thirty minutes following release of the tourniquet, all test groups showed a significant drop in CD_per. The extent of this reduction was maximal in SOD treated muscles, while it was minimized in the lazaroid-treated muscles following 90 min reperfusion. Hyperemia occurred only in muscles treated with saline or lazaroid. The hyperemia was of limited duration in saline-treated muscles, but lasted the entire reperfusion period following lazaroid treatment. An index of microvascular flow, estimated from the product of V_RBC and CD_per, indicated that flow was significantly greater in muscles treated with lazaroids as compared with all other groups following the 90-min reperfusion. We conclude that whereas SOD was detrimental, the lazaroid analogue U-74389F improved microvascular perfusion following 3 h of no-flow ischemia and 90 min reperfusion.

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Amelioration of Lung Ischemic Injury With Prostacyclin

Cited by 43 publications

References 0 publications

Perioperative Prostaglandin E1 Treatment for the Prevention of Postoperative Complications After Esophagectomy: A Randomized Clinical Trial

Perioperative Prostaglandin E1 Treatment for the Prevention of Postoperative Complications After Esophagectomy: A Randomized Clinical Trial

Donor Lung Pretreatment with Prostaglandin E<sub>1</sub> Does Not Improve Lung Graft Preservation

Effect of Superoxide Dismutase and 21-Aminosteroids (Lazaroids) on Microvascular Perfusion following Ischemia-Reperfusion in Skeletal Muscle

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