Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice

Jiang, Lijuan; Han, Xing; Qiu, Wenlin; Yu, Tong; Feng, Ruizhi; Wang, Xuefei; Duan, Xiaoru; Deng, Guo-Min

doi:10.3389/fimmu.2022.824008

Cited by 6 publications

(9 citation statements)

References 49 publications

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“…The immunoreceptor tyrosine-based activation motif (ITAM) embedded in the intracellular structure of FcγR is responsible for signal transduction of IgG and ICs ( 44 , 48 ). The expression of FcγRI, but not of FcγRII and FcγRIII, has been found to be increased in monocytes from SLE patients, and the level of FcγRI expression was found to be related to the SLE disease activity index (SLEDAI) ( 49 ).…”

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

“…We used FcγRI-deficient mice with IgG-induced inflammation to investigate the role of FcγRI in the inflammation induced by SLE ( 49 ). The inflammation induced by IgG was reduced in FcγRI-deficient mice compared with wild-type mice ( 49 ). In addition, the expression level of FcγRI was associated with IgG deposition and skin inflammation in MRL/ lpr mice ( 37 ).…”

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

“…In addition, the expression level of FcγRI was associated with IgG deposition and skin inflammation in MRL/ lpr mice ( 37 ). Activation of the inflammatory signal pathway in monocytes/macrophages required FcγR expression ( 49 ). However, in vitro experiments have shown that IgG reduces the surface expression of FcγRI, but not of FcγRII and FcγRIII, on monocytes/macrophages ( 27 ).…”

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

“…In addition, BAFF, produced by activated macrophages, was found in the region of inflammation to prolong the survival of macrophages in lupus nephritis ( 59 , 60 ). In addition, IL-10, interferon alpha (IFN-α), and interferon gamma (IFN-γ) have been shown to increase CD64 expression in monocytes/macrophages ( 49 , 61 ). In one study, a lack of macrophage migration inhibitory factor (MIF) attenuated infiltration of macrophages and alleviated lupus nephritis ( 62 ).…”

Section: Tnf-α/tnfr1 Plays a Major Role In The Development Of Inflamm...mentioning

confidence: 99%

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The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

Qiu

Deng

2022

Front. Immunol.

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Systemic lupus erythematosus (SLE), often known simply as lupus, is a severe chronic autoimmune disease that is characterized by multi-organ and tissue damage and high levels of autoantibodies in serum. We have recently investigated, using animal models, the role of organ-deposited IgG autoantibodies in the pathogenesis of organ and tissue damage in SLE. We found that intra-organ injection of serum from mice with lupus (i.e., lupus mice) into healthy mice triggered inflammation in tissue and organs but that serum from other healthy mice did not, and that the severity of inflammation was related to the dose of serum injected. Immunohistochemistry showed that a large number of IgG molecules are deposited at the site of organ and tissue damage in lupus mice, and that IgG is a major contributor to the development of tissue inflammation triggered by serum from lupus mice or patients. The development of tissue inflammation induced by IgG in serum from lupus mice requires the presence of monocytes/macrophages, but not of lymphocytes or neutrophils; tumor necrosis factor (TNF)/tumor necrosis factor receptor 1 (TNFR1) and interleukin 1 (IL-1) also play essential roles in the development of tissue inflammation triggered by IgG. In addition, it has been found that TNFR1 inhibitors can suppress skin injury in lupus mice and that spleen tyrosine kinase (Syk) inhibitors, which can block the signaling transduction of IgG/Fc gamma receptors (FcγRs), can prevent and treat skin injury and kidney damage in lupus mice. We have also observed that lupus IgG might protect against bone erosion. Based on these results, we conclude that IgG plays a crucial role in the development of organ and tissue damage in SLE and in protecting bone erosion and arthritis, and we suggest that the IgG/FcγR signaling pathway is an important therapeutic target in SLE.

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Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

Section: Fcγri Is Important For the Development Of Inflammation Induc...mentioning

confidence: 99%

Section: Tnf-α/tnfr1 Plays a Major Role In The Development Of Inflamm...mentioning

confidence: 99%

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The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

Qiu

Deng

2022

Front. Immunol.

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Inhibitory effect of hydroxychloroquine on glucocorticoid‐induced osteoporosis in lupus therapy

Qiu,

Han,

et al. 2024

Clin & Trans Imm

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ObjectivesSystemic lupus erythematosus (SLE) is a chronic and severe autoimmune disease characterised by persistent inflammation. Hydroxychloroquine (HCQ) and glucocorticoids (GCs) are the primary agents commonly used in combination as the first‐line treatment for SLE. Nevertheless, the specific mechanisms responsible for the effectiveness of this combined therapy with HCQ and GCs have not been fully elucidated. This study aimed to reveal the mechanism behind combined HCQ and GC treatment in lupus.MethodsAn SLE IgG‐induced inflammation model was used to investigate the anti‐inflammatory effects of HCQ and dexamethasone (DXM). A glucocorticoid‐induced osteoporosis (GIOP) model was used to investigate the inhibitory effect of HCQ on osteoclastogenesis. Inflammation was assessed by haematoxylin and eosin staining. Bone metabolism was determined structurally via microcomputer tomography and in bone marrow‐derived osteoclast cultures.ResultsAn SLE IgG‐induced inflammation model demonstrated that HCQ could not ameliorate inflammation alone but could enhance the anti‐inflammatory effect of GCs by decreasing the expression of FcγRI on macrophages. HCQ inhibited osteoclastogenesis induced by GCs and RANKL by upregulating nuclear factor erythroid 2‐related factor 2 and limiting reactive oxygen species formation, which mitigated GC‐induced bone loss.ConclusionThe results indicate that HCQ improved the anti‐inflammatory effects of GCs and inhibits the osteoclastogenesis in experimental lupus. This study offers valuable insights into the mechanisms underlying the combined treatment of lupus with HCQ and GCs.

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Immunoglobulin G inhibits glucocorticoid-induced osteoporosis through occupation of FcγRI

Jiang,

Qiu,

Wang

et al. 2023

iScience

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Amelioration of Lupus Serum-Induced Skin Inflammation in CD64-Deficient Mice

Cited by 6 publications

References 49 publications

The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

Inhibitory effect of hydroxychloroquine on glucocorticoid‐induced osteoporosis in lupus therapy

Immunoglobulin G inhibits glucocorticoid-induced osteoporosis through occupation of FcγRI

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