Amelioration of nephritis in receptor for advanced glycation end-products (RAGE)-deficient lupus-prone mice through neutrophil extracellular traps

Watanabe, Hirotaka; Kubo, Masataka; Taniguchi, Akihiko; Asano, Yosuke; Hiramatsu‐Asano, Sumie; Ohashi, Keiji; Zeggar, Sonia; Katsuyama, Eri; Katsuyama, Takayuki; Sunahori-Watanabe, Katsue; Sada, Ken-Ei; Matsumoto, Yoshinori; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Son, Myoungsun; Wada, Jun

doi:10.1016/j.clim.2023.109317

Clinical Immunology

2023

DOI: 10.1016/j.clim.2023.109317

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Amelioration of nephritis in receptor for advanced glycation end-products (RAGE)-deficient lupus-prone mice through neutrophil extracellular traps

Hirotaka Watanabe

Masataka Kubo

Akihiko Taniguchi

et al.

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Cited by 6 publications

References 77 publications

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Neutrophil extracellular traps in homeostasis and disease

Wang,

Kim,

Lei

et al. 2024

Sig Transduct Target Ther

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Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in certain pathological contexts. While NETs may act as autoantigens, aggregated NET complexes can function as inflammatory mediators by degrading proinflammatory cytokines and chemokines. The delineation of molecules and signaling pathways governing NET formation aids in refining our appreciation of NETs’ role in immune homeostasis, inflammation, autoimmune diseases, metabolic dysregulation, and cancer. In this comprehensive review, we delve into the multifaceted roles of NETs in both homeostasis and disease, whilst discussing their potential as therapeutic targets. Our aim is to enhance the understanding of the intricate functions of NETs across the spectrum from physiology to pathology.

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Neutrophil extracellular traps in homeostasis and disease

Wang,

Kim,

Lei

et al. 2024

Sig Transduct Target Ther

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Immune cells in skin inflammation, wound healing, and skin cancer

Zhang,

2023

Journal of Leukocyte Biology

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Given the self-evident importance of cutaneous immunity in the maintenance of body-surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with dysfunction in cutaneous immunity. It is often overlooked by people that skin, well-known as a solid physical barrier, is also a strong immunological barrier considering the abundant presence of immune cells including lymphocytes, granulocytes, dendritic cells and macrophages. What’s more, humoral immune components including cytokines, immunoglobulins and antimicrobial peptides are also rich in the skin. This review will center around skin inflammation (acute and chronic, infection and aseptic inflammation), wound healing and skin cancer to elucidate the elaborate network of immune cells in skin diseases.

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Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases

Chen,

Wang,

Liu

et al. 2023

Current Opinion in Rheumatology

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Purpose of review The exact pathogenic mechanisms of rheumatic diseases (RMD) remain largely unknown. Increasing evidence highlights a pathogenic role of neutrophil dysregulation in the development of RMD. Recent findings The purpose of this review is to present a current overview of recent advancements in understanding the role of neutrophil dysfunction in the development of RMD. Additionally, this review will discuss strategies for targeting pathways associated with neutrophil dysregulation as potential treatments for RMD. One specific aspect of neutrophil dysregulation, known as neutrophil extracellular traps (NETs), will be explored. NETs have been found to contribute to chronic pulmonary inflammation and fibrosis, as well as serve as DNA scaffolds for binding autoantigens, including both citrullinated and carbamylated autoantigens. Putative therapies, such as 6-gingerol or defibrotide, have demonstrated beneficial effects in the treatment of RMD by suppressing NETs formation. Summary Recent advances have significantly reinforced the crucial role of neutrophil dysregulation in the pathogenesis of RMD. A deeper understanding of the potential mechanisms underlying this pathogenic process would aid in the development of more precise and effective targeting strategies, thus ultimately improving the outcomes of RMD.

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Amelioration of nephritis in receptor for advanced glycation end-products (RAGE)-deficient lupus-prone mice through neutrophil extracellular traps

Cited by 6 publications

References 77 publications

Neutrophil extracellular traps in homeostasis and disease

Neutrophil extracellular traps in homeostasis and disease

Immune cells in skin inflammation, wound healing, and skin cancer

Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases

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