Amelioration of Ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in White Leghorn cockerels

Khatoon, Aisha; Khan, Muhammad Zargham; Khan, Ahrar; Saleemi, Muhammad Kashif; Javed, Ijaz

doi:10.3109/1547691x.2012.686533

Cited by 45 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo lympho-proliferative response of the broilers indicated that OTA led to poorer responses to PHA-P. Elaroussi et al (2006) reported the similar decreased response in broilers fed OTA for 35 Days. The observed decrease in in situ phagocytic activity was also consistent with previous reports of Khatoon et al (2013) andul-Hassan et al (2011a,b,c). Taking together the effects seen here on granulocyte phagocytic function and the known effects on B-and T-lymphocytes, it is likely that OTA led to reduce titers of antibodies against the SRBC as a culmination of multiple effects on the function of key cells involved in processing of this antigen and ultimate generation of antibody against it.…”

Section: Discussionsupporting

confidence: 93%

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers

Bhatti

Khan

Saleemi

et al. 2017

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

The present study was designed to investigate any ameliorative effects of bentonite (BN) against immuno-pathological alterations induced by dietary aflatoxin B (AFB) or ochratoxin A (OTA) in broiler chicks. In one experiment, AFB (0.1, 0.2 or 0.6 mg/kg feed) was fed alone and par alley with bentonite clay (3.7 or 7.5 g/kg feed) to the broilers. In the second experiment, the broilers were given feed contaminated with OTA (0.15, 0.3 or 1.0 mg/kg feed) alone and in combination with bentonite clay (3.7, 7.5, or 15 g/kg feed). Experimental feedings were continued for 42 days. At various time points along the feeding schedule, immune system organ histologic status, as well as host humoral and cellular immune responses, were evaluated in all groups. The dietary addition of AFB and OTA alone significantly reduced immune responses in the birds as assessed by histological changes in the bursa of Fabricius and thymus, antibody responses to SRBC, in-vivo lympho-proliferative responses to Phytohemagglutinin-P (PHA-P) and, phagocytic function in situ. The dietary addition of BN significantly ameliorated the immunotoxicity of 0.1 and 0.2 mg/kg dietary AFB, however with a level of 0.6 mg AFB/kg only partial amelioration was seen. The co-treatment of birds exposed to OTA with BN at all levels only partially alleviated deleterious effects on histology and immune responses. Taken together, the results here suggested to us that dietary addition of BN could help ameliorate AFB-mediated immunotoxicities but could not afford such protection against OTA-induced immune damage.

show abstract

Section: Discussionsupporting

confidence: 93%

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers

Bhatti

Khan

Saleemi

et al. 2017

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, in feed SLsupplementation @ 250 mg.kg −1 lowered the serum activity of ALT and AST when compared to control. Similar hepatoprotective effects of SL have been reported in poultry in ochratoxins toxicity (Khatoon et al, 2013).…”

Section: Discussionsupporting

confidence: 82%

Cadmium Toxicity in Female Japanese quail (Coturnix japonica) and Its Diminution with Silymarin

Butt¹,

Saleemi²,

Khan³

et al. 2018

PVJ

View full text Add to dashboard Cite

Present study was designed to investigate the toxico-pathological effects of cadmium in female Japanese quail (Coturnix japonica) and their attenuation by silymarin. A total of 120 quail chicks of four weeks of age were assigned into six groups and given basal feed, Cd1 (150 mg.kg −1 feed), Cd2 (300 mg.kg −1 feed) and SL (250 mg.kg −1 feed) alone and in combinations for 60 days. Hematological parameters, serum biochemical profile, feed intake, bodyweights, relative organ weights, egg production and histopathological alterations in kidney and oviduct were noted. Our results showed dose dependent decrease in mean relative weight of oviduct but increase in liver, intestine, kidney and spleen in groups treated with Cd only. Feed intake was decreased in Cd groups compared with control and bodyweight of Cd treated groups was lower as compared with control and SL groups. The Hb and PCV values were low but higher values of blood urea, creatinine, and serum activity of AST and ALT were observed in Cd treated groups only. Reduced height of mucosal folds collapsed tubular glands, nuclear degenerative changes and infiltration of plasma cells in parenchymatous tissue of oviduct were observed in Cd treated groups only. Moreover, Cd exposure resulted into hemorrhage, casts in tubules, infiltration of mononuclear cells, tubular necrosis and fibrosis in kidneys. Egg production was also lower in Cd treated groups as compared with control group. It may be concluded that Cd has strong nephrotoxic and gonadotoxic effects and SL may effectively ameliorate these toxic effects completely at lower doses but partially at higher doses of Cd.

show abstract

“…The mitogen, ochratoxin A (OTA) was used at the rates of 0.15, 0.3 and 1.0mg/kg in this study for a period of 42 days and the selection of these levels was made on the basis of different available studies in which OTA was used in the diet at the rates ranging from 0.13 to 8.0 mg/kg feed in birds (Santin et al, 2002;Elaroussi et al, 2006;Khatoon et al, 2013;Abidin et al, 2013;Marin and Taranu. 2015).…”

Section: Discussionmentioning

confidence: 99%

Toxicopathological and Serum Biochemical Alterations Induced by Ochratoxin a in Broiler Chicks and Their Amelioration by Locally Available Bentonite Clay

Khatoon¹,

Khan²,

Khan

et al. 2016

PAKJAS

Self Cite

View full text Add to dashboard Cite

Ochratoxin A (OTA), a potent carcinogen, poses a great threat to the lives of poultry, animals and humans. It causes nephrotoxicity, immunosuppression, mutagenicity and teratogenicity in birds. Bentonite clay, belonging to the subclass of aluminosilicates, has the ability to adsorb different molecules and can efficiently adsorb several mycotoxins too. The present study was designed to evaluate the ameliorative effects of locally available bentonite clay against OTA induced toxicopathological and serum biochemical alterations in broilers. For this, day old broilers were divided into 16 equal groups and were given different combinations of OTA (0.15, 0.3 and 1.0 mg/kg feed) and bentonite clay (5, 10 and 20 g/kg feed). Results indicated that feeding OTA alone caused a reduction in body weight gain, poor FCR, increased gross lesions, altered relative organ weights and serum biochemical values and all these changes occurred in a dose dependent manner. Feeding bentonite clay along with OTA did not ameliorate the OTA induced alterations in body weight, FCR, gross lesions, relative organ weights and serum biochemical parameters.

show abstract

Amelioration of Ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in White Leghorn cockerels

Cited by 45 publications

References 37 publications

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers

Cadmium Toxicity in Female Japanese quail (Coturnix japonica) and Its Diminution with Silymarin

Toxicopathological and Serum Biochemical Alterations Induced by Ochratoxin a in Broiler Chicks and Their Amelioration by Locally Available Bentonite Clay

Contact Info

Product

Resources

About

Amelioration of Ochratoxin A-induced immunotoxic effects by silymarin and vitamin E in White Leghorn cockerels

Cited by 45 publications

References 37 publications

Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers

Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers

Cadmium Toxicity in Female Japanese quail (Coturnix japonica) and Its Diminution with Silymarin

Toxicopathological and Serum Biochemical Alterations Induced by Ochratoxin a in Broiler Chicks and Their Amelioration by Locally Available Bentonite Clay

Contact Info

Product

Resources

About

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers

Protective role of bentonite against aflatoxin B₁- and ochratoxin A-induced immunotoxicity in broilers