Amelioration of osteopenia and hypovitaminosis D by 1alpha -hydroxyvitamin D3 in elderly patients with Parkinson's disease

Satō, Yoshihiro; Manabe, S.; Kuno, Haruko; Ōizumi, Kōtaro

doi:10.1136/jnnp.66.1.64

Cited by 107 publications

(56 citation statements)

References 29 publications

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“…Computed x-ray densitometry (CXD) (Teijin Diagnostics) 21 employing an improved microdensitometric method was used to quantify BMD in both second metacarpals of each patient, as previously described. 22 The computer algorithm for CXD compares bone radiodensity with the gradations of an aluminum step wedge, calculating bone thickness as an aluminum equivalent (mm Al) showing the same x-ray absorption. The reference range for BMD for both sexes combined aged 65 to 75 years was 2.69 to 2.71 mm Al.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Risk of Hip Fractures Among Disabled Elderly Stroke Patients

Satō

Asoh

Kondo

et al. 2001

Stroke

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Background and Purpose-Risk of hip fracture after stroke is 2 to 4 times that in a reference population. Osteomalacia is present in some patients with hip fractures in the absence of stroke, while disabled elderly stroke patients occasionally have severe deficiency in serum concentrations of 25-hydroxyvitamin D (25-OHD) (Յ5 ng/mL). To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years. Methods-We compared baseline serum indices of bone metabolism, bone mineral density, and hip fracture occurrence in stroke patients with serum 25-OHD Յ25 nmol/L (Յ10 ng/mL; deficient group, nϭ88) with findings in patients from the same cohort who had 25-OHD levels 26 to 50 nmol/L (10 to 20 ng/mL; insufficient group, nϭ76) or Ն51 nmol/L (Ն21 ng/mL; sufficient group, nϭ72). Results-Over a 2-year follow-up interval, hip fractures on the paretic side occurred in 7 patients in the deficient group and 1 patient in the insufficient group (PϽ0.05; hazard ratioϭ6.5), while no hip fractures occurred in the sufficient group. The 7 hip fracture patients in the deficient group had an osteomalacic 25-OHD level of Ͻ5 ng/mL. Higher age and severe immobilization were noted in the deficient group. Serum 25-OHD levels correlated positively with age, Barthel Index, and serum parathyroid hormone. Conclusions-Elderly disabled stroke patients with serum 25-OHD concentrations Յ12 nmol/L (Յ5 ng/mL) have an increased risk of hip fracture. Immobilization and advanced age cause severe 25-OHD deficiency and consequent reduction of BMD.

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Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency and Risk of Hip Fractures Among Disabled Elderly Stroke Patients

Satō

Asoh

Kondo

et al. 2001

Stroke

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“…7 Compensatory hyperparathyroidism associated with deficient 25-OHD levels and immobilization induce increased bone resorption and contribute to reduced BMD and occurrence of hip fractures. 8,9 Prevention of a hip fracture, which is likely to offset gains from rehabilitation and preclude new gains, is extremely important. Our results from previous studies have indicated that alfacalcidol 9 and menatetrenone 10 can prevent decrease in BMD in elderly patients with PD.…”

mentioning

confidence: 99%

“…8,9 Prevention of a hip fracture, which is likely to offset gains from rehabilitation and preclude new gains, is extremely important. Our results from previous studies have indicated that alfacalcidol 9 and menatetrenone 10 can prevent decrease in BMD in elderly patients with PD.…”

mentioning

confidence: 99%

Retracted: Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial

et al. 2006

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Incidence of a fracture, particularly in the hip joint, is high in elderly women with Parkinson's disease (PD), and this is due to the immobilization-induced bone resorption and vitamin D deficiency with reduced bone mineral density (BMD). The objective of this study was to address the possibility that treatment with alendronate and vitamin D2 may reduce the incidence of hip fractures in elderly women with PD. PD patients were randomly assigned to daily treatment with 5 mg alendronate (n = 144) or a placebo combined with 1,000 IU of vitamin D2 (n = 144) and followed for 2 years. Incidence of hip fractures in the two patient groups during the 2-year follow-up period was studied. At baseline, both groups of patients had low BMD with high levels of serum-ionized calcium and urinary deoxypyridinoline (D-Pyr). Hip fractures occurred in 14 patients in the placebo group and 4 in the alendronate group. The relative risk for hip fractures in the alendronate group as compared with the placebo group was 0.29 (95% CI, 0.10-0.85). The number of hip fracture per 1,000 patient-years was 14 and 49 for the alendronate and placebo groups, respectively. In the alendronate group, serum calcium and urinary D-Pyr levels decreased significantly during the follow-up period, while the levels in the placebo group were increased. BMD increased by 3.1% in the alendronate group and decreased by 2.8% in the placebo group (P < 0.01). Treatment with alendronate and vitamin D2 increases BMD in elderly women with PD and leads to the prevention of hip fractures.

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“…4). 13,14,[63][64][65][66][67][68][69] Slightly more positive conclusions could be drawn when the supplement was given to institutionalized old individuals, where the total number of falls was reduced by 28% (RR 0.72, 95% CI 0.55-0.95) (Fig. 4).…”

Section: Vitamin Dmentioning

confidence: 99%

Prevention of falls in old people – a review

Karlsson

Cöster

et al. 2013

Rev. Clin. Gerontol.

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SummaryPhysical training, if including specific different training modalities, reduces the fall risk in healthy communitydwelling older people, as does a home hazards modification programme. Vitamin D supplementation in older individuals with low levels of vitamin D, adjustment of psychotropic medication, and structured modification of multi-pharmacy are all drug-focused programmes that reduce the number of falls. Antislip shoe devices during icy conditions for older people who walk outdoors and multifaceted podiatry in patients with specific foot disability reduce the fall risk. First eye cataract surgery and pacemakers in patients with cardio-inhibitory carotid sinus hypersensitivity are surgical interventions that reduce the fall risk. Multifactorial preventive programmes that include training, both individually designed and generally prescribed, also reduce the fall frequency. With this in mind, we ought to initiate fall preventive programmes in older people, especially in high-risk groups, to reduce the number of falls and fallers in society.

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Amelioration of osteopenia and hypovitaminosis D by 1alpha -hydroxyvitamin D3 in elderly patients with Parkinson's disease

Abstract: (J Neurol Neurosurg Psychiatry 1999;66:64-68)

Cited by 107 publications

References 29 publications

Vitamin D Deficiency and Risk of Hip Fractures Among Disabled Elderly Stroke Patients

Vitamin D Deficiency and Risk of Hip Fractures Among Disabled Elderly Stroke Patients

Retracted: Alendronate and vitamin D2 for prevention of hip fracture in Parkinson's disease: A randomized controlled trial

Prevention of falls in old people – a review

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