Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components

Katsarou, Ageliki I; Kaliora, Andriana C.; Chiou, Antonia; Kalogeropoulos, Nick; Papalois, Αpostolos; Agrogiannis, George; Andrikopoulos, Nikolaos K.

doi:10.1007/s00394-015-0947-5

Cited by 29 publications

(22 citation statements)

References 59 publications

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“…Based on previous investigations, plant sterols lower the LDL cholesterol level, with no impact on the HDL cholesterol or triglyceride concentrations [3,6]. Further, in the present study, HDL cholesterol concentrations did not differ between treatments, while TG levels were found to be higher in the HCD-treated groups compared with the controls, which could be attributed to the method used for inducing the hypercholesterolemia, in line with other studies [17].…”

Section: In Vivo Studysupporting

confidence: 92%

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β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

et al. 2020

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The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessibility and release were extensively studied. Both NLC preparations remained relatively stable during the four weeks of storage at different conditions (4, 25 and 40 °C), with more superior stability at lower temperatures. The in vitro digestion experiment indicated a high physical stability after exposure to the simulated mouth and stomach stages and an improved overall β-sitosterol bioaccessibility at the end of the digestion. The NLCs presented an increased solubility and gradual release which could be justified by the remarkable affinity of β-sitosterol to the complex lipid mixture. An in vivo study demonstrated an improved reduction in the total cholesterol and low-density lipoprotein cholesterol plasma levels in mice compared with the drug suspension. These investigations evidenced the potential of the developed NLC formulations for the enhancement of solubility and in vivo performance of β-sitosterol.

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Section: In Vivo Studysupporting

confidence: 92%

“…Previous studies have shown that the lipid matrix and nature of the colloidal interactions operating between oil droplets considerably affects the stability of lipid nanoparticles [10][11][12][13][14][15][16][17][18][19][20]. In this study, wax-based NLCs were stabilized by Tween 80 and lecithin.…”

Section: Physical and Chemical Stabilitymentioning

confidence: 88%

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

et al. 2020

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“…A shorter period (4 weeks) required the concomitant administration of 0.1% astaxanthin to induce superoxide dismutase and glutathione peroxidase activities in male KK‐A (y) mice fed a high fat/sucrose diet despite the use of 2% squalene . Likewise, the decrease in malondialdehyde in hearts was observed in Wistar rats fed a high cholesterol diet supplemented with 10% extra virgin olive oil for 9 weeks . These findings emphasize the crucial role of experimental design in terms of dose, time period, and animal model.…”

Section: Squalene and Cardiovascular Diseasementioning

confidence: 72%

Current Insights into the Biological Action of Squalene

Lou-Bonafonte

Martínez‐Beamonte

Sanclemente

et al. 2018

Molecular Nutrition Food Res

126

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Squalene is a triterpenic compound found in a large number of plants and other sources with a long tradition of research since it was first reported in 1926. Herein a systematic review of studies concerning squalene published in the last 8 years is presented. These studies have provided further support for its antioxidant, anti-inflammatory, and anti-atherosclerotic properties in vivo and in vitro. Moreover, an antineoplastic effect in nutrigenetic-type treatments, which depends on the failing metabolic pathway of tumors, has also been reported. The bioavailability of squalene in cell cultures, animal models, and in humans has been well established, and further progress has been made in regard to the intracellular transport of this lipophilic molecule. Squalene accumulates in the liver and decreases hepatic cholesterol and triglycerides, with these actions being exerted via a complex network of changes in gene expression at both transcriptional and post-transcriptional levels. Its presence in different biological fluids has also been studied. The combination of squalene with other bioactive compounds has been shown to enhance its pleiotropic properties and might lead to the formulation of functional foods and nutraceuticals to control oxidative stress and, therefore, numerous age-related diseases in human and veterinary medicine.

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“…The Mediterranean diet, which is rich in olive oil, is associated with the reduction in mortality from cardiovascular diseases, cancer risk and skin wrinkling . In addition, aged rats fed lifelong with olive oil present the lowest number of histological, molecular and biochemical alterations in heart, liver and pancreas throughout the ageing process . These studies indicate that oral administration of olive oil may be the better option to attenuate the signs of skin ageing.…”

Section: Discussionmentioning

confidence: 89%

Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular‐signal‐related kinase 1/2 and c‐JUN pathways

Romana‐Souza

Monte‐Alto‐Costa

2019

Intern J of Cosmetic Sci

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Objective Chronic stress‐induced oxidative damage and protease synthesis cause a loss of extracellular matrix components promoting human skin ageing. The administration of antioxidant compounds, such as those observed in olive oil, may attenuate stress‐induced ageing signs in human skin. Thus, the aim of this study was to investigate the effect of olive oil administration in ex vivo stressed human skin. Methods Explants of human skin were treated with high levels of epinephrine (as observed in stressed patients) and olive oil in medium for 13 days. Cultures treated with medium alone were used as controls. Results Olive oil reversed the high epinephrine level‐induced reduction in epidermis and dermis thickness and collagen fibre content in ex vivo human skin. The increase in the production of reactive oxygen species (ROS) and malondialdehyde levels (an index of lipid peroxidation) promoted by high levels of epinephrine were also attenuated by olive oil in ex vivo human skin. Moreover, olive oil was able to reverse the high epinephrine level‐induced increase in extracellular signal‐related kinase 1/2 (ERK 1/2) and c‐JUN (a major component of transcription factor AP‐1) phosphorylation and protein matrix metalloproteinase‐2 (MMP‐2) expression in ex vivo human skin. Conclusion Olive oil attenuates stress‐induced ageing signs (thinner dermis and collagen fibre loss) in ex vivo human skin by reducing MMP‐2 expression, ROS production, and ERK 1/2 and c‐JUN phosphorylation.

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Amelioration of oxidative and inflammatory status in hearts of cholesterol-fed rats supplemented with oils or oil-products with extra virgin olive oil components

Abstract: Overall, we suggest that the EVOO-polar phenolic compounds decreased MDA and TNF-α in hearts of cholesterol-fed rats.

Cited by 29 publications

References 59 publications

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

Current Insights into the Biological Action of Squalene

Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular‐signal‐related kinase 1/2 and c‐JUN pathways

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