Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats

Gürsul, Cebrail; Özçiçek, Adalet; Özkaraca, Mustafa; Mendil, Ali Sefa; Çoban, Taha Abdulkadir; Arslan, Aykut; Özçıçek, Fatih; Süleyman, Halis

doi:10.1538/expanim.21-0143

Cited by 6 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MDA is one of the most frequently researched, reliable, and popular products of oxidative stress and LPO. An increase in MDA is associated with biological damage, and a decrease is associated with protection [23][24][25]. In the current study, the increase in the amount of MDA in the gastric tissue of animals administered indomethacin is consistent with the literature and indicates oxidative stress [21,26].…”

Section: Discussionsupporting

confidence: 90%

Effect of felodipine on indomethacin-induced gastric ulcers in rats

et al. 2023

View full text Add to dashboard Cite

Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties.Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically in animals treated with felodipine (5 mg/kg) and famotidine in combination with indomethacin. The results were compared with those of the healthy control group and the group administered indomethacin alone. It was observed that felodipine suppressed the indomethacin-induced malondialdehyde increase (p< 0.001); reduced the decrease in total glutathione amount (p< 0.001), reduced the decrease superoxide dismutase (p< 0.001), and catalase activities (p< 0.001); and significantly inhibited ulcers (p< 0.001) at the tested dose compared with indomethacin alone. Felodipine at a dose of 5 mg/kg reduced the indomethacin-induced decrease in cyclooxygenase-1 activity (p< 0.001) but did not cause a significant reduction in the decrease in cyclooxygenase-2 activity. The antiulcer efficacy of felodipine was demonstrated in this experimental model. These data suggest that felodipine may be useful in the treatment of nonsteroidal anti-inflammatory drug-induced gastric injury.

show abstract

Section: Discussionsupporting

confidence: 90%

Effect of felodipine on indomethacin-induced gastric ulcers in rats

et al. 2023

View full text Add to dashboard Cite

show abstract

“…36 In addition, it was shown that increased inflammatory cells and pro-inflammatory mediators were associated with ROS production. 37…”

Section: Discussionmentioning

confidence: 99%

Favipiravir-induced inflammatory and hydropic degenerative liver injury in rats

et al. 2023

View full text Add to dashboard Cite

Background. Favipiravir is very effective in the treatment of many viral infections, especially at high doses.It was used at such doses to treat coronavirus disease 2019 (COVID-19) during the pandemic. However, liver damage was reported in patients undergoing such treatment.Objectives. This study aimed to investigate the effects of low and high doses of favipiravir on the liver of rats, using biochemical and histopathological methods. Materials and methods.Wistar albino rats were allocated to one of 3 groups, namely a healthy group (HG), a 100 mg/kg favipiravir (FAV-100) group and a 400 mg/kg favipiravir (FAV-400) group. Favipiravir was administered orally at 100 mg/kg and 400 mg/kg doses to the FAV-100 (n = 6) and FAV-400 (n = 6) groups, respectively. Distilled water was administered orally (1 mL) using the same method to the HG (n = 6). This procedure was repeated twice a day for 1 week. At the end of this period, the animals were euthanized with a high dose of thiopental anesthesia (50 mg/kg) and their liver tissues were removed. Results.Favipiravir caused an increase in malondialdehyde (MDA), nuclear factor kappa B (NF-κB) and interleukin 6 (IL-6) levels in the liver tissue, as well as elevated alanine aminotransaminase (ALT) and aspartate aminotransferase (AST) levels in the blood. Moreover, favipiravir caused a decrease in total glutathione (tGSH), superoxide dismutase (SOD) and catalase (CAT) levels. In addition, severe edema, lymphocyte infiltration and hydropic degeneration were observed in the liver tissue of the FAV-400.Conclusions. High-dose favipiravir caused more significant oxidative and inflammatory damage in the liver tissue of rats than low-dose favipiravir.

show abstract

“…This suggests that in the acrylamide group, antioxidant systems are insufficient to neutralize ROS. Gursul et al reported that carvacrol protected the liver tissue from oxidative damage by preventing the decrease in tGSH and TAS ( Gursul et al, 2022 ). In another study, it was reported that carvacrol protects liver tissue against oxidative stress ( Imtara et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.

show abstract

Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats

Cited by 6 publications

References 32 publications

Effect of felodipine on indomethacin-induced gastric ulcers in rats

Effect of felodipine on indomethacin-induced gastric ulcers in rats

Favipiravir-induced inflammatory and hydropic degenerative liver injury in rats

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Contact Info

Product

Resources

About