Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice

Thingore, Chetan; Kshirsagar, Viplav; Juvekar, Archana R.

doi:10.1007/s11011-020-00629-9

Cited by 35 publications

(16 citation statements)

References 145 publications

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“…E) in diabetic rats [101]. This result was confirmed by Baranauskaite et al [97] and Thingore et al [106], which proved a decrease in MDA concentration and an increase in SOD and CAT activities after treatment with rosmarinic acid. On the other hand, the study of Dianat and their colleagues demonstrated that vanillic acid reduced the malondialdehyde content, as well as elevated SOD, CAT, and GPx activities on ischemia-reperfusion-induced oxidative stress in isolated rat hearts [99].…”

Section: Vanillic Acidsupporting

confidence: 58%

“…Numerous reports have evaluated the antioxidant activities of phenolic acids (Table 2) [97][98][99][100][101][102][103][104][105][106][107][108]. In a study reported by Tolba et al [107], caffeic acid showed a potential antioxidant activity by enhancing glutathione peroxidase content and SOD activity and significantly decreasing femur bone MDA in glucocorticoid-induced osteoporosis in vivo.…”

Section: Phenolic Acidsmentioning

confidence: 99%

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Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

et al. 2021

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ROS (reactive oxygen species) are produced via the noncomplete reduction in molecular oxygen in the mitochondria of higher organisms. The produced ROS are placed in various cell compartments, such as the mitochondria, cytoplasm, and endoplasmic reticulum. In general, there is an equilibrium between the synthesis of ROS and their reduction by the natural antioxidant defense system, called the redox system. Therefore, when this balance is upset, the excess ROS production can affect different macromolecules, such as proteins, lipids, nucleic acids, and sugars, which can lead to an electronic imbalance than oxidation of these macromolecules. Recently, it has also been shown that ROS produced at the cellular level can affect different signaling pathways that participate in the stimulation of transcription factors linked to cell proliferation and, consequently, to the carcinogenesis process. Indeed, ROS can activate the pathway of tyrosine kinase, MAP kinase, IKK, NF-KB, phosphoinositol 3 phosphate, and hypoxia-inducible factor (HIF). The activation of these signaling pathways directly contributes to the accelerated proliferation process and, as a result, the appearance of cancer. In addition, the use of antioxidants, especially natural ones, is now a major issue in the approach to cancer prevention. Some natural molecules, especially phytochemicals isolated from medicinal plants, have now shown interesting preclinical and clinical results.

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Section: Vanillic Acidsupporting

confidence: 58%

Section: Phenolic Acidsmentioning

confidence: 99%

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

et al. 2021

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“…The levels of IL-1β, TNF-α, nitric oxide, and prostaglandin E2 were increased with the activation of the NF-κB signaling pathway [101]. Thingore et al [102] reported that LPS administration enhanced neuroinflammation and contributed to oxidative stress through a decrease in reduced glutathione, superoxide dismutase, and increases in lipid peroxidation in the brains of mice. Treatment with 2,4,6-trinitrobenzenesulfonic acid in mice caused colitis and increased membrane permeability, levels of LPS, Enterobacteriaceae (including Escherichia coli) with a decrease in Lactobacillus johnsonii in the GM composition, activated NF-κB and TNF-α, and displayed cognitive impairment.…”

Section: Bacterial Amyloids and Lipopolysaccharides In Admentioning

confidence: 99%

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

et al. 2021

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The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may disturb intestinal permeability and the blood–brain barrier. In addition, it can promote the hallmarks of AD, such as oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, and ultimately the causation of neural death. Poor dietary habits and aging, along with inflammatory responses due to dysbiosis, may contribute to the pathogenesis of AD. Thus, GM modulation through diet, probiotics, or fecal microbiota transplantation could represent potential therapeutics in AD. In this review, we discuss the role of GM dysbiosis in AD and potential therapeutic strategies to modulate GM in AD.

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“…Abnormal protein accumulation and deposition, such as neurofibrillary tangles, Lewy body, tau protein, and α-synuclein, constitute the major histological marker of neuropathologic diagnosis (Gibb and Lees 1988 ). Numerous in vivo and in vitro studies demonstrated that natural compounds with high anti-oxidative and anti-inflammatory properties might be essential in managing neurodegenerative diseases, including epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), memory impairment, and sclerosis (Ghasemzadeh and Hosseinzadeh 2020 ; Thingore et al 2021 ). RA is well-known for combating ROS production and inflammatory response, highlighting its clinical significance in reducing neurodegenerative damage (Fachel et al 2019 ).…”

Section: Clinical Implications Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice

Cited by 35 publications

References 145 publications

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

Biomedical features and therapeutic potential of rosmarinic acid

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