Amelioration of Pterostilbene Antiproliferative, Proapoptotic, and Oxidant Potentials in Human Breast Cancer MCF7 Cells Using Zein Nanocomposites

Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells

“…The poor water solubility of ETD was also required to be enhanced in order to increase the dissolution rate and the bioavailability [ 5 ]. The nanomedicine approach offers distinguished and remarkable amelioration in the delivery of candidate drug molecules in order to support its bioavailability [ 28 ], bioaccessibility [ 29 ], cytotoxicity [ 18 ], apoptosis [ 30 ] and repositioning profiles [ 31 ]. The present study aimed to develop ZN nano-formulations loaded with ETD in order to obtain fortified potential against HepG2 cells as repositioning molecules.…”

“…The greater encapsulation within SDZN NSs and the augmented biodistribution of ETD will also support the antiproliferative profile [ 35 , 36 ]. The reported ZN cytotoxicity [ 18 , 30 ] may clarify the acquired cytotoxicity activity of the ETD-SDZN NSs.…”

“…ZN nanoparticles were considered promising carriers for enhancing the antioxidant potential of several drugs [ 18 , 30 ].…”

“…ETD-SDZN NSs’ colloidal stability was examined in Fetal Bovine Serum (FBS, Gibco, Thermo Fisher Scientific, Waltham, MA, USA) [ 30 ]; 1 mL of 70% FBS was added to 200 µL of sample suspension and was then incubated at 37 °C for 48 h followed by magnetic stirring at 600 rpm. At selected time intervals of incubation, particle size analysis was carried out for the sample as measured in Section 3.3.1 .…”

“…This assay was performed as described by [ 18 , 30 ] using the same cell culture plates, kit, reagents, software and IC 50 value for 24 h incubation.…”