Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

Abstract

Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.

Potential effects of ultraviolet-C radiation on the mole rats (&lt;i&gt;Spalax leucodon&lt;/i&gt;) hematological values

“…According to these data, a significant decrease in erythrocyte values (from 8.76 ± 1.42 to 7.65 ± 1.40) on the 14th, 30th days, but an increase (9.65 ± 0.89) was noted on the 45th day of UV exposure ( Figure 2). Our findings correlate well with the data derived from human, fish, rats and mice [11,[17][18][19].…”

“…The increase is consistent with the studies performed on humans [19] and rats [11], but decrease in hemoglobin values were performed on mice, calves, sheep and fish [9,17,18,20].…”

“…To our knowledge, plenty of data have been gathered concerning the effects of UVA and UVB radiations on biochemical, hematological or histopathological characteristics of animals [8][9][10][11][12][13][14][15][16][17][18], but similar studies done with UVC radiation on the hematological cells on Mole rats (Spalax leucodon) have not been encountered.…”

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

“…Furthermore, oral administration of ginseng root extracts to albino mice prior to whole-body exposure to γ-radiation increased survival rates and life expectancy, restored the levels of a number of endogenous antioxidants, including GST, CAT and SOD-1, and inhibited radiation-induced sickness and weight loss (92). These extracts also significantly decreased the increased level of radiation-mediated lipid peroxidation (92,96).…”

Influence of Ultraviolet on Morphology Structure, Blood Structure and Rheological Properties of Blood Serum of Mice

“…Hematological parameters and blood variables are closely related to the response of the animal to the environment and used as reliable indicators of health status to detect physiological changes following different stress conditions [1]. Though biological effects of UVA and UVB radiations have been studied on several animal species [7][8][9][10][11][12] but the effects of UVC radiation are poorly studied. Therefore, the current study was conducted to show the biological changes of mice exposed to artificially produced UVC radiation for different periods.…”