Amelioration of the DSS‑induced colitis in mice by pretreatment with 4,4'‑diaponeurosporene‑producing Bacillus subtilis

Abstract

Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4′-diaponeurosporene)-producing Bacillus subtilis markedly ameliorated dextran sulfate sodium salt-induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4′-diaponeurosporene may have beneficial effects on treatments for colitis. This preliminary study indicated that 4,4′-diaponeurosporene may function synergistically with probiotics to provide a novel and effective strategy to prevent colitis.

Comparison of oral and nasal immunization with inactivated porcine epidemic diarrhea virus on intestinal immunity in piglets

“…In the present study, B. subtilis served only as an immunopotentiator to enhance the local mucosal immune response. Furthermore, a previous study has demonstrated the immune effects of B. subtilis after oral administration in pigs ( 41 ). Additionally, the number of healthy pigs was limited due to a recent outbreak of African swine fever in China.…”

Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation

“…Adding Bacillus subtilis to Vivomixx® improved the beneficial effects of the bacterial therapy in the TNBS model of colitis. The Bacillus subtilis –Vivomixx® mixture had additive effects, in comparison with Bacillus subtilis alone and Vivomixx® alone, in reducing the body weight lost and the severity of colitis, highlighting the potential beneficial effects of Bacillus subtilis in the context of a multi-strains probiotic preparation [ 12 , 13 , 14 , 15 , 16 ].…”

“…Results from mouse models have provided evidence that Bacillus subtilis effectively protects against development of immune dysfunction and signs and symptoms of colitis in rodent models of colitis caused by dextran sodium sulfate (DSS). In this model, feeding with Bacillus subtilis promoted an increased biodiversity of the intestinal microbiota, recovery of intestinal tight junctions, along with enhanced generation of beneficial bacterial products such as short chain fatty acids (SCFAs) [ 12 , 13 , 14 , 15 , 16 ]. These beneficial effects were supported by a decreased production of pro-inflammatory cytokines such as Il-6 and Il -17 along with an increased generation of anti-inflammatory mediators such as Il-10 and Tgf-β [ 12 , 13 , 14 , 15 , 16 ], leading to the polarization of intestinal macrophages towards a tolerogenic, anti-inflammatory, M2 phenotype [ 13 ].…”

Seaweeds: An Extensive Review of Medicinal Values

“…The [ 13 C]-Spirulina platensis GEBT is an easy to measure of gastric emptying with accuracy [331][332][333]. Laminaria japonica (vomiting, hemorrhoids, IBD, probiotic synergist) [334,335], Eucheuma cottonii (IBD, hepatoprotective, anti-food allergy) [336][337][338], Caulerpa Mexicana (Figure 15) (Gastroprotective, IBD) [339][340][341], Hypnea musciformis (IBD) [336,342], Fucus vesicolosus (gastroprotective, ulcerative colitis) [117,343], Laminaria hyperborean, Laminaria digitate (IBD) [344,345], Undaria pinnatifida ( Figure 16) (improves gut health) are reported in gut health modulation [346]. In addition, seaweed polysaccharides are atypical in structure to terrestrial glycans, and were found to resist gastric acidity, host digestive enzymes, and GI absorption [347].…”