Ameliorative Action of Mn-Salen Derivatives on CCl&amp;lt;sub&amp;gt;4&amp;lt;/sub&amp;gt;-Induced Destructive Effects and Lipofuscin-Like Pigment Formation in Rats’ Liver and Brain: Post-Treatment of Young Rats with EUKs

Meftah, Sakineh; Yazdanparast, Razieh; Molaei, Mahsa

doi:10.4236/cellbio.2014.33010

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Thus, the authors reported that EUK-8 and EUK-134 reduced the sera aminotransferases, the extent of lipid peroxidation, low density lipoprotein contents, cholesterol, and protein carbonylation. The same research group published another study about the protective effects of EUK-8, EUK-15, EUK-115, EUK-122, EUK-132, and EUK-134 against CCl 4 -induced damages in rats [ 150 ]. The manganosalen complexes ameliorated the effects of CCl 4 by decreasing the levels of ROS, lipid and protein oxidations, and lipofuscin-like pigments formation on the liver and brain.…”

Section: Therapeutic Effects Of Manganosalen Complexes In In Vivo mentioning

confidence: 99%

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

et al. 2020

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Manganosalen complexes are coordination compounds that possess a chelating salen-type ligand, a class of bis-Schiff bases obtained by condensation of salicylaldehyde and a diamine. They may act as catalytic antioxidants mimicking both the structure and the reactivity of the native antioxidant enzymes active site. Thus, manganosalen complexes have been shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess reactive oxygen species (ROS), thereby restoring the redox balance in damaged cells and organs. Initial catalytic studies compared the potency of these compounds as antioxidants in terms of rate constants of the chemical reactivity against ROS, giving catalytic values approaching and even exceeding that of the native antioxidative enzymes. Although most of these catalytic studies lack of biological relevance, subsequent in vitro studies have confirmed the efficiency of many manganosalen complexes in oxidative stress models. These synthetic catalytic scavengers, cheaper than natural antioxidants, have accordingly attracted intensive attention for the therapy of ROS-mediated injuries. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage. These disorders, ranging from the prevention of fetal malformations to the extension of lifespan, include neurodegenerative, inflammatory, and cardiovascular diseases; tissue injury; and other damages related to the liver, kidney, or lungs.

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Section: Therapeutic Effects Of Manganosalen Complexes In In Vivo mentioning

confidence: 99%

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus, the authors reported that EUK-8 and EUK-134 reduced the sera aminotransferases, the extent of lipid peroxidation, low density lipoprotein contents, cholesterol, and protein carbonylation. The same research group published other study about the protective effects of EUK-8, EUK-15, EUK-115, EUK-122, EUK-132 and EUK-134 against CCl4-induced damages in rats [154]. The manganosalen complexes ameliorated the effects of CCl4 by decreasing the levels of ROS, lipid and protein oxidations and lipofuscin-like pigments formation on liver and brain.…”

Section: Adrenal and Liver Diseasesmentioning

confidence: 88%

Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review

Rouco¹,

Pedrido²,

Maneiro³

2020

Preprint

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Manganosalen complexes are coordination compounds that possess a chelating salen-type ligand, a class of bis-Schiff bases obtained by condensation of salicylaldehyde and a diamine. They may act as catalytic antioxidants mimicking both the structure and the reactivity of the native antioxidant enzymes active site. Thus, manganosalen complexes have shown to exhibit superoxide dismutase, catalase, and glutathione peroxidase activities, and they could potentially facilitate the scavenging of excess ROS, thereby restoring the redox balance in the damaged cells and organs. Initial catalytic studies compared the potency of these compounds as antioxidants in terms of rate constants of the chemical reactivity against ROS, giving catalytic values approaching and even exceeding that of the native antioxidative enzymes. Although most of these catalytic studies lack of biological relevance, subsequent in vitro studies have confirmed the efficiency of many manganosalen complexes in oxidative stress models. These synthetic catalytic scavengers, cheaper than natural antioxidants, have accordingly attracted intensive attention for the therapy of ROS-mediated injuries. The aim of this review is to focus on in vivo studies performed on manganosalen complexes and their activity on the treatment of several pathological disorders associated with oxidative damage. This disorders, ranging from the prevention of fetal malformations to the extension of lifespan, include neurodegenerative, inflammatory and cardiovascular diseases, tissue injury, and other damages related to liver, kidney or lungs.

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“…Carbon tetrachloride (CCl 4 ) is a widely used as an environmental toxicant model and well known to generate ROS, induce lipid peroxidation, damage to different organs, including the liver, kidneys, heart, brain and testis [3]. The mechanism by which CCl 4 induce its toxicity mainly due to the bio-activation into trichloromethyl peroxy radical ( • OOCCl 3 ) and trichloromethyl radical ( • CCl 3 ) by the cytochrome P450 [4].…”

Section: Introductionmentioning

confidence: 99%

Zinc loaded whey protein nanoparticles mitigate the oxidative stress and modulate antioxidative gene expression in testicular tissues in rats

Abdel‐Wahhab

Hassan

El‐Nekeety

et al. 2021

Journal of Drug Delivery Science and Technology

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This study aimed to utilize whey protein nanoparticles (WPNPs) and zinc (Zn) loaded WPNPs to protect against carbon tetrachloride (CCl 4 )-induced testicular damage in rats. Zn was loaded on WPNPs at three levels and Zn release was determined at different time intervals. Seventy male Wistar rats were divided into 7 groups and treated orally for 4 weeks as follows: the control group, CCl 4 -treated group (0.5 ml/100 g b.w) twice a week, CCl 4 plus WPNPs-treated group (300 mg/kg b.w), CCl 4 plus Zn citrate-treated group (50 mg/kg b.w), and the groups treated with CCl 4 plus the three Zn-WPNPs formulations. Blood and testicular tissue samples were collected for different assays. Animals treated with CCl 4 showed a significant decrease in body weight and relative weight of the testis, testosterone level, antioxidant enzymes activity and mRNA expression of Nrf2, HO-1 and NQO1 and increased Malondialdehyde (MDA), nitric oxide (NO) and mRNA expression of Keep1 and induced histological changes in the testis. WPNPs alone, Zn alone or Zn loaded WPNPs at the three levels protect against CCl 4 -induced testicular damage. These effects were more pronounced in the group received the fabrication with low Zn level. This study concluded that Zn-WPNPs could reduce the oxidative stress in the testicular tissue via different mechanisms mainly via the regulation of Nrf2-Keap1 antioxidative signaling pathway.

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Ameliorative Action of Mn-Salen Derivatives on CCl<sub>4</sub>-Induced Destructive Effects and Lipofuscin-Like Pigment Formation in Rats’ Liver and Brain: Post-Treatment of Young Rats with EUKs

Abstract: How to cite this paper: Meftah, S., Yazdanparast, R. and Molaei, M. (2014)

Cited by 4 publications

References 35 publications

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

Pursuing the Elixir of Life: In Vivo Antioxidative Effects of Manganosalen Complexes

Pursuing the Elixir of Life: In Vivo Antioxidative Effect of Manganosalen Complexes, a Review

Zinc loaded whey protein nanoparticles mitigate the oxidative stress and modulate antioxidative gene expression in testicular tissues in rats

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