Ameliorative Anti-Diabetic Activity of<i>Dangnyosoko</i>, a Chinese Herbal Medicine, in Diabetic Rats

Kim, Jong-Dae; Kang, Seock-Man; Park, Mee-Yeon; Jung, Tae‐Young; hae-yun, Choi; Ku, Sae‐Kwang

doi:10.1271/bbb.70058

Cited by 30 publications

(19 citation statements)

References 30 publications

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“…Plasma insulin levels were assayed with enzyme-linked immunosorbent assay kit (ELISA; Boehringer Mannheim GmbH, Mannheim, Germany) as previously detailed (27).…”

Section: Plasma Insulin Levelsmentioning

confidence: 99%

“…Based on the previous histomorphometrical analysis of metabolic mice (29) or diabetic rats (27,30), adipocyte deposition and hypertrophy, percentages of pancreatic zymogen granule occupied regions, pancreatic islet numbers, and occupied percentages were determined. The mean diameters of epididymal and dorsal abdominal white adipocytes were calculated as an indicator of adipocyte hypertrophy in restricted view fields on a computer monitor using an automated image analysis system (iSolution FL ver.…”

Section: Plasma Insulin Levelsmentioning

confidence: 99%

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Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The potato (Solanum tuberosum) has been cultivated globally for food for millenia. Potato contains proteinase inhibitor II, which catalyzes the release of cholecystokinin (CCK), leading to delayed gastric emptying in humans. The present study investigated the anti-obesity effects of Slendesta™ Potato Extract (SLD), a standardized potato extract containing 5% proteinase inhibitor II, in the ob/ob obese mice. Three doses of SLD (50, 150 or 300 mg/kg) were orally administered to ob/ob mice once a day for 28 days, whereas control mice were administered distilled water. Four weeks after SLD treatment, the changes in body weight, food consumption, epididymal fat weight, serum chemistry, insulin, leptin and adiponectin contents, and fat histopathology were determined and compared with ob/ob mice treated with 750 mg/kg conjugate linoleic acid. As a result of SLD treatment in the obese mice, body weight, food consumption, epididymal fat, serum biochemistry, histomorphological changes of fat and pancreas were significantly and dose-dependently decreased compared with ob/ob control mice. These obesity and type 2 diabetes associated alterations were significantly inhibited after SLD treatment for 28 days. Thus, the present results indicate that SLD has potential as an alternative therapeutic agent for obesity.

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“…Plasma insulin levels were assayed with enzyme-linked immunosorbent assay kit (ELISA; Boehringer Mannheim GmbH, Mannheim, Germany) as previously detailed (27).…”

Section: Plasma Insulin Levelsmentioning

confidence: 99%

Section: Plasma Insulin Levelsmentioning

confidence: 99%

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Sung²,

Choung³

et al. 2016

Experimental and Therapeutic Medicine

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“…Statistical studies that were carried out in Australia and US indicated that almost 48.5% and 34% of individuals had used at least one unconventional therapy, respectively (Kim et al, 2007;Momtaz & Abdollahi, 2010). In developing countries, about 65-80% of the world population depends primarily on plants for their health care due to poverty and lack of access to modern medicine (Calixto, 2005;Momtaz & Abdollahi, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In the last decade, many researchers have reported efficacy of herbal medicines in many diseases. According to statistical data reported several times (Kim et al, 2007;Momtaz & Abdollahi, 2010), in currently prescribed synthetic drugs, approximately 25% of active compounds were first identified in plant resources. Moreover, 20 000 plants have been used for medicinal purposes some of which around 4000 have been used commonly.…”

Section: Introductionmentioning

confidence: 99%

A pharmacological and phytochemical overview onSatureja

Tepe

Çilkiz

2015

Pharmaceutical Biology

102

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Context: Satureja (Lamiaceae) species are used as flavoring compounds in food, pharmaceutical, and cosmetic industries because of its sweetness and simple cultivation characteristics. They have traditionally been used as muscle pain relievers, tonic, and carminative agents to treat stomach and intestinal disorders such as cramps, nausea, indigestion, and diarrhea, due to their considerable phytochemical characteristics. Objective: This review evaluates some information published since 1989 on Satureja genus from a systematic perspective in terms of its pharmacological and phytochemical characteristics. Materials and methods: Web of Science, PubMed, Scopus, and Google Scholar databases were searched up to March 2014. ''Satureja'' was used as a research term without narrowing or limiting research elements. After obtaining all reports from database (a total number is about 637), the papers were carefully analyzed in order to find data related to the topic of this review. Results: In this review, 453 reports were used which were published between 1989 and 2014. The study was compiled into two sections (Pharmacology and Phytochemistry). In the pharmacology section, more than 50 different activities were studied. In the second section, in addition to other compounds and inorganic substances, volatiles, phenolic acids, and flavonoids were discussed. Discussion and conclusion: According to our contemporary information, Satureja species have been evaluated for their wide range of biological activities. However, a small part of these studies have been carried out on the active principles. Therefore, in the future, more studies should be carried out to identify responsible phytochemicals for the various activities.

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“…For many reasons in recent years the popularity of alternative medicine has increased, this has led to increasing demands for herbal products with anti diabetic activity and less side effects [10]. Flavonoids occur commonly, and are widespread, in the plant kingdom.…”

Section: Introductionmentioning

confidence: 99%

Effect of Quercetin on the Endocrine Pancreas of the Experimentally Induced Diabetes in Male Albino Rats: A Histological and Immunohistochemical Study

Rifaai¹,

El‐Tahawy²,

Saber³

et al. 2012

J Diabetes Metab

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Background: Insulin dependent diabetes mellitus is a chronic metabolic disease. Many drugs used in its treatment which have a number of serious adverse effects. Natural agent as quercetin (QCT) has been suggested in the alternative medicine for treatment of diabetes mellitus. Aim of the work:To evaluate the effect of QCT on the histological changes which occur in the islet of Langerhans of the streptozotocin (STZ)-induced diabetic rats and the possible mechanisms through which QCT produces its protective effect. Materials and methods:Fourty five male albino rats were divided into 3 groups: Group I, control group; 15 rats received single intraperitoneal injection of citrate buffer saline. Group II, diabetic group; 15 rats received single intraperitoneal injection of STZ. Group III; QCT-treated group, 15 rats received daily intraperitoneal injections of QCT for 30 days prior to, and for 30 days after the single injection of STZ. Blood samples were taken for monitoring blood glucose levels. Pancreas was taken out and processed for light microscopic, immunocytochemical and morphometrical studies.Results: Blood glucose levels showed a significant increase in group II compared to the control, while a significant decrease was observed in groups III compared to group II (all p<0.05). In the hematoxylin-eosin stained sections, STZ administration caused marked degeneration of islet Beta cells with inflammatory cells infiltration. Using QCT; in group III, reversed most of the pancreatic morphological changes, and interestingly some islets noticed with connections to some pancreatic ducts. In chrome alum heamatoxylin stained sections, STZ administration caused a significant decrease in the number of bluish stained β cells compared to controls. While group III showed a significant increase in β cells number compared to group II (all p<0.05). Sections of animals injected with charcoal, showed many charcoal labeled macrophages in group II compared to group III, and controls. There was increased iNOS and caspase 3 immunoreactivity in islets cells of group II than in controls, and was decreased in group III. Conclusion:This study provides evidence that quercetin could exert a protective effect against β cell damage by its anti-inflammatory, anti-apoptotic, and antioxidant effects; and aids regeneration of β cells which might through stimulation of the ductal stem cells. However, further experimental studies are still needed for more details on quercetin as an adjuvant drug in management of diabetes mellitus. Journal of Diabetes and MetabolismCitation: Rifaai RA, El-Tahawy NF, Saber EA, Ahmed R (2012) Effect of Quercetin on the Endocrine Pancreas of the Experimentally Induced Diabetes in Male Albino Rats: A Histological and Immunohistochemical Study. J Diabetes Metab 3:182.

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Ameliorative Anti-Diabetic Activity ofDangnyosoko, a Chinese Herbal Medicine, in Diabetic Rats

Cited by 30 publications

References 30 publications

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice

A pharmacological and phytochemical overview onSatureja

Effect of Quercetin on the Endocrine Pancreas of the Experimentally Induced Diabetes in Male Albino Rats: A Histological and Immunohistochemical Study

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