Ameliorative effect of aqueous leaf extract of Solanum aethiopicum on phenylhydrazine-induced anaemia and toxicity in rats

Ekweogu, C.N.; Ude, Victor Chibueze; Nwankpa, Promise; Emmanuel, Okezie; Ugbogu, Eziuche Amadike

doi:10.1007/s43188-019-00021-5

Cited by 34 publications

(16 citation statements)

References 30 publications

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“…The results of the food intake are shown in 1 shows that food intake decreased significantly (P<0.05) in females whatever be the dose and in males treated with 800 mg/kg of bw compared to control females and males respectively. Similar results were reported by Celestine et al [23] who showed that in rats, the administration of S. aethipicum aqueous leaves extracts at 200 and 400 mg/kg reduced food intake, probably due to the presence of dietary fiber [24] .…”

Section: Sub-acute Toxicity Effect Of Oral Administration Of S Aethiopicum Linn Gilo Leaves Extract On Food Intakesupporting

confidence: 88%

“…Table 2 shows that growth rate decreased significantly (p<0.05) in females and males treated with 800 mg / kg/bw compared to the other groups and at the fourth week respectively. Celestine et al [23] reported similar results in rats treated with aqueous leaves extract of S. aethiopicum at 200 and 400 mg/kg bw. Weight control may be due to the combine action of dietary fiber and polyphenols as mentioned by Ayodele [25] .…”

Section: Effect Of Oral Administration Of S Aethiopicum Leaves Extract On Body Weightmentioning

confidence: 65%

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Untitled

2022

J Pharmacogn Phytochem

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The aims of this study was to evaluate the acute and sub-acute toxicity of Solanum aethiopicum Linn Gilo aqueous leaves extract in Wistar rats. Female rats received a single dose (2000, 3000, 4000 and 5000 mg/kg/ bw) of the extract for acute toxicity. Both, male and female rats received 300,500 and 800 mg/kg/ bw during 21 days for sub-acute toxicity measurements. Blood sample was collected for the determination of some haematological, biochemical and oxidative stress parameters. Besides, the histological sections of the liver, heart, lungs and kidneys were analyzed. Results showed that the lethal dose of the extract greater than 5000mg/kg. the extract did not alter the haematological parameters. It maintained blood sugar and proteinuria within normal limits and had good antioxidant activity. The histopathological analysis revealed normal architecture of lung, kidney, heart and liver. Solanum aethiopicum LINN GILO aqueous leaves extract at doses of 300,500,800mg/kg/bw has therefore shown any sign of toxicity.

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Section: Sub-acute Toxicity Effect Of Oral Administration Of S Aethiopicum Linn Gilo Leaves Extract On Food Intakesupporting

confidence: 88%

Section: Effect Of Oral Administration Of S Aethiopicum Leaves Extract On Body Weightmentioning

confidence: 65%

Untitled

2022

J Pharmacogn Phytochem

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“…Eggplant also contains traces of minerals such as copper, zinc, and iron [18]. Due to this biochemical composition, eggplant may possibly be used in the treatment of anemia, atherosclerosis, and fatty degeneration [19][20][21]. Its antioxidant property potentially reduces the risk of various types of cancer, protects against cardiovascular diseases, and prevents acute respiratory infections.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Composition of Eggplant Fruits: A Review

Sharma

Kaushik

2021

Applied Sciences

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Eggplant is one of the most important vegetable crops known for its nutritive benefits due to the abundance of various bioactive compounds, which include proteins, vitamins, minerals, carbohydrates, phenolics, and dry matter content. In addition, eggplant has significant pharmaceutical properties that have been recently recognized. Eggplant produces secondary metabolites, including glycoalkaloids, antioxidant compounds, and vitamins, which appear to be the major source of its health benefits. It has been reported that there is a considerable correlation between the regular use of phytochemicals and the defense against diseases. Therefore, researchers must analyze the biochemical composition of eggplants to obtain more information about their nutritional quality and health benefits. In this review, an attempt is made to explain the qualitative and quantitative aspects of different biochemicals present in eggplant, in addition to their beneficial health effects.

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“…The use of medicinal plants in traditional and complementary medicine for the treatment, management, or prevention of various diseases is as old as the origin of mankind ( Yuan et al., 2016 ; Ekweogu et al., 2019 ). It has been estimated that approximately 80% of the world's population depends mainly on ethnomedicine or herbal medicine for the treatment of numerous diseases worldwide ( Joshi, 2013 ; Pant, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Ugbogu

Emmanuel

Agi

et al. 2021

Heliyon

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In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and bacterial infections. The present study reviewed the phytochemicals, essential oils, and pharmacological activities of O. gratissimum . The bioactive compounds extracted from O. gratissimum include phytochemicals (oleanolic acid, caffeic acid, ellagic acid, epicatechin, sinapic acid, rosmarinic acid, chlorogenic acid, luteolin, apigenin, nepetoidin, xanthomicrol, nevadensin, salvigenin, gallic acid, catechin, quercetin, rutin, and kaempfero) and essential oils (camphene, β-caryophyllene, α- and β-pinene, α-humulene, sabinene, β-myrcene, limonene, 1,8-cineole, trans-β-ocimene, linalool, α- and δ-terpineol, eugenol, α-copaene, β-elemene, p-cymene, thymol, and carvacrol). Various in vivo and in vitro studies have shown that O. gratissimum and its bioactive constituents possess pharmacological properties such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrhoeal, and antimicrobial properties. This review demonstrated that O. gratissimum has a strong preventive and therapeutic effect against several diseases. The effectiveness of O. gratissimum to ameliorate various diseases may be attributed to its antimicrobial and antioxidant properties as well as its capacity to improve the antioxidant systems. However, despite the widespread pharmacological activities of O. gratissimum , further experiments in human clinical trial studies are needed to establish effective and safe doses for the treatment of various diseases.

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Ameliorative effect of aqueous leaf extract of Solanum aethiopicum on phenylhydrazine-induced anaemia and toxicity in rats

Cited by 34 publications

References 30 publications

Untitled

Untitled

Biochemical Composition of Eggplant Fruits: A Review

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

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