Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Abstract

Antidepressants induced metabolic syndrome is a major public health problem in the treatment of psychiatric disorders which leads to an increased risk of cardiovascular disease, non-alcoholic hepatic steatosis and renal dysfunction. Psychiatric disorder is a mental illness that includes depression, schizophrenia, and anxiety disorder that affect millions of people around the world. The purpose of present study was to investigate the protective role of broccoli powder against continuous ingestion of antidepressant drug induced nephrotoxicity in Swiss albino mice. In present study mice were continuously treated with escitalopram antidepressant drug (20 mg/kg/b.w. orally) for 4, 8 and 12 weeks. The escitalopram drug intoxicated group showed elevation in serum urea and creatinine level. Escitalopram drug intoxicated group also showed degeneration of glomerulus and renal tubule that are comparable with carbon tetrachloride (33 mg/kg) group considered as positive control. Group that received both broccoli powder and escitalopram drug (200 mg/kg + 20 mg/kg) significantly reduced elevated level of serum urea and creatinine with mild degeneration of glomerulus and renal tubule as compared to antidepressant drug intoxicated group.