2018
DOI: 10.1159/000496109
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Ameliorative Effect of Cardamom Aqueous Extract on Doxorubicin-Induced Cardiotoxicity in Rats

Abstract: This study was conducted to evaluate the potential cardioprotective effect of cardamom (CAR) against myocardial injuries induced by doxorubicin (DOX) in rats through investigation of histological alterations and the associated oxidative stress, apoptosis, inflammation, and angiogenesis. This study included 30 adult male albino rats that were randomized to 3 groups (n = 10/group): group I (control), group II (DOX) rats injected with DOX (2.5 mg/kg body weight [BW] i.p.) every other day for 2 weeks, and group II… Show more

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Cited by 37 publications
(25 citation statements)
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“…Group VII rats which served as the positive control group were equally pretreated with 20 mg/kg/day of Vitamin C 3 hours before treatment with 2.5 mg/kg of doxorubicin in 0.9% normal saline administered intraperitoneally on alternate days for 14 days. Group VIII rats were the untreated normal rats and were orally pretreated with 10 ml/kg/day of distilled water 3 hours before treatment with 2.5 mg/kg of doxorubicin in 0.9% normal saline administered intraperitoneally on alternate days for 14 days ( Table 1 ) [ 50 , 51 ]. The choice of vitamin C was made because it is a standard antioxidant agent, and its effect as a positive control was compared with other treatment groups.…”
Section: Methodsmentioning
confidence: 99%
“…Group VII rats which served as the positive control group were equally pretreated with 20 mg/kg/day of Vitamin C 3 hours before treatment with 2.5 mg/kg of doxorubicin in 0.9% normal saline administered intraperitoneally on alternate days for 14 days. Group VIII rats were the untreated normal rats and were orally pretreated with 10 ml/kg/day of distilled water 3 hours before treatment with 2.5 mg/kg of doxorubicin in 0.9% normal saline administered intraperitoneally on alternate days for 14 days ( Table 1 ) [ 50 , 51 ]. The choice of vitamin C was made because it is a standard antioxidant agent, and its effect as a positive control was compared with other treatment groups.…”
Section: Methodsmentioning
confidence: 99%
“…After identifying certain substances, we did not find a proper match for a positive control. Moreover, recently published studies did not include positive controls [ 33 , 34 ]. Toxicity studies were not performed since methylxanthines have been well studied, and the doses used in the present study are significantly lower than the lethal doses of caffeine, theobromine, and theophylline in rats.…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress is one of the basic mechanisms involved in metal-induced toxicity (El-Kassas et al, 2019;Stohs and Bagchi, 1995). In consequence, the search for effective, nontoxic, natural compounds with antioxidant activity has been intensified in recent years (Abu Gazia and El-Magd 2018b;Negrette-Guzmán et al, 2013). L-arginine, a nitric oxide precursor, is used in current basic and clinical research because of its important therapeutic properties (Alderton et al, 2001).…”
Section: Discussionmentioning
confidence: 99%