Ameliorative Effect of Chronic Moderate Exercise in Smoke Exposed or Nicotine Applied Rats From Acute Stress

Kuru, Pinar; Bilgin, Seyda; Mentese, Semih Tiber; Tazegül, Gökhan; Ozgur, Sevinc; Çilingir, Özlem Tuğçe; Akakın, Dilek; Yarat, Ayşen; Kasımay, Özgür

doi:10.1093/ntr/ntu182

Cited by 8 publications

(7 citation statements)

References 61 publications

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“…Clinical trials have indicated that chronic physical exercise can have antidepressant and anxiolytic effects [21][22][23]. Furthermore, moderate intensity exercise also reduces oxidative stress [24,25], implying that exercise can be an effective and cost-efficient therapeutic alternative for a variety of anxiety and mood-related disorders. Although exercise has been shown as a therapeutic tool in most of the studies, nonvoluntary chronic exercise may be a stressor due to experimental design, housing or testing environment, rearing and handling situations in animal studies [26].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of exercise and sildenafil on acute stress and cognitive function

Özbeyli¹,

Gokalp²,

Koral³

et al. 2015

Physiology & Behavior

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Section: Introductionmentioning

confidence: 99%

Protective effect of exercise and sildenafil on acute stress and cognitive function

Özbeyli¹,

Gokalp²,

Koral³

et al. 2015

Physiology & Behavior

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“…24 It has been reported that the amount of lipid peroxidation depends on the intensity, duration and mode of exercise. For example, a short-term of high-intensity exercise can increase speed of lipid peroxidation which caused by oxidative stress, 25 - 27 while long period exercise can diminish lipid peroxidation process and prevents tissue from damaging. 28 , 29 The discrepancies between the present findings and those of other results could be related to the duration, intensity and mode of exercise used during this experiment.…”

Section: Discussionmentioning

confidence: 99%

Influence of Two Various Durations of Resistance Exercise on Oxidative Stress in the Male Rat’s Hearts

Ghiasi

Mohammadi

et al. 2015

J Cardiovasc Thorac Res

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Introduction: The previous studies have suggested that alteration in oxidative stress and antioxidant defense depends on various factors, such as mode, intensity, frequency and duration of exercise. In this study, we compared the effects of two various durations of resistance exercise (1 month and 4 month) on oxidative stress and antioxidant status in cardiac tissue. Methods: Thirty Wistar male rats divided into 3 groups: control (sedentary), exercise-1 (regular exercise for 1 month) and exercise-2 group (regular exercise for 4 months). After the final to the experiment, the rats were anesthetized, and then blood and heart samples were obtained and used to determine glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA) and biochemical estimation. Results: MDA levels between control and exercise-2 groups showed no significant difference, hence, MDA level in exercise-1 group was higher compared to control group (P < .01). The heart GPX activity increased significantly in exercise-2 group regarding other groups (P < .01). The SOD activities of groups were similar. Creatine kinase (CK) and lactate dehydrogenase (LDH) concentrations increased in the exercise-1 compared to the other groups (P < .01). Conclusion: Our results indicate that in heart, the adaptation and alteration in oxidative stress and cell injury level depend on duration of exercise.

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“…Each time six rats were placed in the in the mechanical smoking box and exposed to four cigarettes at 15‐minute intervals. The procedure was applied 6 days a week, for 5 weeks …”

Section: Methodsmentioning

confidence: 99%

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

Özbeyli

Berberoglu

Özen

et al. 2016

Clin Exp Pharma Physio

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The role of second hand smoke (SHS) exposure on ulcerative colitis is not known. Our aim was to examine the effects of α-lipoic acid (ALA), chronic aerobic (AE) or resistance exercise (RE) on SHS exposed rats with colitis. Sprague-Dawley male rats (150-200 g, n=54) were selected for colitis induction. Among the colitis groups, one group was exposed to SHS (6 d/wk, 4 cigarettes/d) and the other was not. The SHS group was divided into subgroups as follows: sedentary; AE (swimming; 3 d/wk); and RE (climbing with weight; 3 d/wk). After 5 weeks, colitis was induced by intrarectal acetic acid. All groups had subgroups that were given subcutaneously ALA (50 mg/kg per day) or vehicle for 3 days. Following decapitation, colon tissues were sampled to examine malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol and lucigenin chemiluminenscence, macroscopic scoring and histologic examination. ANOVA and Student's t-test were used for statistical analysis. The increased macroscopic and microscopic scores, MPO, MDA, luminol and lucigenin measurements in colitis and SHS-colitis groups were decreased via ALA (P<.05-.001). AE declined macroscopic and microscopic scores, MDA, lucigenin compared to colitis and SHS-colitis groups (P<.01-.001). RE reduced microscopic score, MPO, MDA, luminol, lucigenin (P<.05-.001) that were increased with colitis. Decreased GSH levels (P<.01) in the SHS-colitis group approached to control levels when given ALA. According to our results SHS and colitis induction increased inflammatory damage. SHS did not worsen it more than colitis. Our results suggest that ALA, AE or RE might be protective for SHS exposed ulcerative colitis conditions.

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Ameliorative Effect of Chronic Moderate Exercise in Smoke Exposed or Nicotine Applied Rats From Acute Stress

Abstract: Biochemical parameters and histological scoring indicated increased tissue injury due to nicotine application and cigarette smoke exposure and exercise training ameliorated these effects in most of the tissues of acute stress induced rats.

Cited by 8 publications

References 61 publications

Protective effect of exercise and sildenafil on acute stress and cognitive function

Protective effect of exercise and sildenafil on acute stress and cognitive function

Influence of Two Various Durations of Resistance Exercise on Oxidative Stress in the Male Rat’s Hearts

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

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