Ameliorative effect of dandelion (Taraxacum officinale) peptides on benzo(a)pyrene‐induced oxidative stress and inflammation in human umbilical vein endothelial cells

Abstract

Dandelion (Taraxacum officinale) is widely consumed as a health food and a traditional medicine. However, the protective effect of dandelion bio‐active peptides (DPs) against polycyclic aromatic hydrocarbon‐induced blood vessel inflammation and oxidative damage is not well documented. In the current study, four novel DPs were isolated using an activity tracking method. The protective activity of the DPs against benzo(a)pyrene (Bap)‐induced human umbilical vein endothelial cell (HUVEC) damage was explored. The results indicated that DP‐2 [cycle‐(Thr‐His‐Ala‐Trp)] effectively inhibited Bap‐induced reactive oxygen species (ROS) and malondialdehyde (MDA) overproduction and reinforced antioxidant enzyme activity while inhibiting the production of inflammatory factors in HUVECs. Moreover, DP‐2 increased NAD(P)H:quinone oxidoreductase 1, heme oxygenase‐1, and nuclear factor E2‐releated factor 2 expression levels by activating the PI3K/Akt signaling pathway. In addition, DP‐2 attenuated Bap‐induced HUVEC apoptosis via the Bcl‐2/Bax/cytochrome c apoptotic pathway. These results suggest that DP‐2 is a promising compound for protecting HUVECs from Bap‐induced inflammatory and oxidative damage.

External application of dandelion combined with borneol effectively reduced pain and facial swelling after jaw surgery

“…Dandelion belongs to the 2 meridians of the spleen and stomach of the human body, dissipating heat and poison, eliminating carbuncles and malignant sores and tuberculosis, dissolving food poison, and dispersing stagnant gas, which has the functions of reducing heat, detoxification, swelling and dispersing accumulation. [ 17 ] Xie et al showed that dandelion contains sterols, anti-inflammatory components, that reduce knee osteoarthritis in rats. [ 18 ] A previous study reported that the dandelion flavonoid is an effective anti-inflammatory and antibacterial compound.…”

Small-Molecule Peptides from Lactiplantibacillus plantarum SCS2 Attenuate H2O2-Induced Oxidative Damage in INS-1 Cells via Regulating the Keap1-Nrf2 Signaling Pathway

“…Similarly, the peptides extracted from the swim bladders of monkfsh have shown signifcant antioxidative potential, reducing the risk of potential diseases triggered by oxidative stress [24]. Furthermore, peptides with bioactive properties derived from dandelions and purifed from watermelon seed hydrolysates have demonstrated antioxidative capabilities [25,26].…”

Taraxacum officinale Extracts Alleviate Anhedonia and Depression by Inhibiting UPRmt and Mitophagy in the Hippocampi of T2DM Rats

“…Taraxacum officinale is a perennial herb of Asteraceae. It is rich in proteins, fatty acids, polysaccharides, amino acids, vitamins, trace elements, flavonoids, phenolic acids, sterols, and other such compounds (Cai et al, 2023). Extracts from T. officinale demonstrate pharmacological effects, including relieving oxidative stress, regulating blood glucose levels, and improving immunity (Choi et al, 2022).…”