Ameliorative Effect of Hesperidin on Carbon Tetrachloride Induced Liver Fibrosis in Rats

Abdel-sttar, Asmaa Ramadan; Khalaf, Marwa M.; Abo-Youssef, Amira M.; Abo-Saif, Ali A.

doi:10.22159/ijpps.2017v9i7.17611

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…Moreover, the serum profile of these rats showed a significant elevation of cholesterol level, which could lead to the accumulation of the lipid droplets in the liver. These results were in accordance with the previous studies 41,42 . The ALT and AST activities showed no significant change compared to the control rats in addition to the dramatic depletion of albumin level.…”

Section: Discussionsupporting

confidence: 94%

Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

Abu‐Serie

Habashy

2020

Sci Rep

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Human is subjected from his surrounding to various hepatotoxins, which aggravates his liver. nowadays, natural polyphenols have attracted great interest in health improvement, especially liver health. the present research, therefore, assessed the hepatotherapeutic potency of the isolated polyphenols (VVF1) from seedless (pulp and skin) black Vitis vinifera (VV) against CCl 4 -induced hepatotoxicity in vitro and in vivo. Further, VVF1 was fractionated into resveratrol-enriched (VVF2) and phenolics-enriched (VVF3) fractions to study (in vitro) the possible synergism of their coexistence. The highest content of phenolics in VVF1 displayed in vitro synergistic antioxidant and anti-hepatotoxic activities comparing to VVF2, VVF3, and silymarin (SM, reference drug). More importantly, it exhibited multiple in vivo regulatory functions via diminishing oxidative stress and inflammation, which in turn decreased necroptosis and pro-fibrotic mediators (mixed lineage kinase domain-like protein (MLKL), collagen type I alpha 1 chain (COL1A1), and transforming growth factor (TGF)-β1). In addition to these novel findings, VVF1 had higher anti-hepatotoxic potency than that of SM in most of the studied parameters. The histopathological analysis confirmed the improving role of VVF1 in the serious hepatic damage induced by ccl 4 . Thus, the synergistic functions of VVF1 polyphenols could be a promising new anti-hepatotoxic agent for targeting both necroptotic and profibrotic mediators.The liver is the largest organ of the body and the main defense organ against environmental and metabolic toxins. Administration of certain medicinal, chemical, or industrial agents can induce hepatotoxicity. Due to the conversion of these hepatotoxins into reactive metabolites by the hepatic cytochrome P450 (CYP) metabolizing enzymes 1 . Carbon tetrachloride (CCl 4 ) is a well-known hepatotoxin that caused liver cell damage by inducing hepatic oxidative stress, inflammation, and necroptosis 2,3 . Necroptosis is a pathophysiological process called programmed necrosis and combines the features of both necrosis and apoptosis-dependent inflammatory cell death. Hence, it is a highly regulated process involving specific molecules (e.g., pro-necroptotic mixed lineage kinase domain-like protein (MLKL) and at the same time associated with a membrane integrity defect 4 . All of these damage effects lead to hepatic steatosis, fibrosis, cirrhosis, and may develop into hepatocellular carcinoma if the hepatotoxin persist 2,3 .Medicinal plants have crucial roles in health care and improving multiple human disorders. Grape (Vitis vinifera, VV) is one of the medicinal plants used in folk medicine and belongs to the Vitaceae family with a woody climbing vine and large leaves 5 . It can grow all over the world "non-climacteric fruit" and is considered to be the most broadly planted fruit crop and the most consumed fruits worldwide. The VV is rich in sugars, organic open Scientific RepoRtS | (2020) 10:2452 | https://doi.org/10.1038/s41598-020-59489-z www.nature.com/scienti...

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Section: Discussionsupporting

confidence: 94%

Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

Abu‐Serie

Habashy

2020

Sci Rep

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“…On the other hand, HDL concentration significantly decreased by 47.97%. High levels of serum TC, LDL and TG, and lower concentration of HDL were induced with CCl 4 in rats, consistent with results recorded from previous studies [44,48]. The obtained results may be attributed to the increase of the non-essential fatty acids resulted from lipid peroxidation induced by CCl 3…”

Section: Effect Of Experimental Treatments On Bloodsupporting

confidence: 91%

“…Furthermore, destroying of lipidperoxidation of cell membranes due to the reaction of CCl 4 with O 2 forming CCl 3 O 2 • , which resulted in the elevation of liver marker enzymes activities i.e. ALT, AST and ALP in blood serum [42], MDA level elevation [43] and the significant increase of total cholesterol, triglycerides, LDL and significant decrease of HDL level [44].…”

mentioning

confidence: 99%

Punica granatum L var nana: A Hepatoprotective and Curative Agent Against CCl4 Induced Hepatotoxicity in Rats

et al. 2021

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Since prehistoric times, medicinal plants and their extracts had been used as prolific sources of medications. Pomegranate is a symbol of life, longevity and in Aurvedic medicine; pomegranate is considered a pharmacy up to itself. Despite several previous studies centered to the phytochemistry and pharmacological actions of all Punica granatum L. components, however, to date, few reports about the variety nana, which implies that this species is yet under-investigated. Punica granatum L. var. nana is a dwarf variety of Punica granatum popularly planted as an ornamental plant in gardens. This study aims to determining the biomedical potentiality of the methanolic extract of Punica granatum L. var. nana leaves as source of botanical hepatoprotective and hepatocurative agents. The methanolic extract exhibited hepatoprotective and curative effects against CCl 4 induced hepatotoxicity in rats and both effects were preventive and curative. The histopathological studies support the hepatoprotective and curative effects by restoring the normal tissue architecture. Furthermore, this extract was found to be safe by using experimental albino rats suggesting that it may be utilized as a potential source of some beneficial bioactive compounds.

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“…AbdelSttar et al [41] studied that hesperidin (3,5,7-trihydroxy flavanone-7-rhamnoglucoside) and a flavanone glycoside present abundantly in citrus fruits, significantly ameliorated carbon tetrachloride (liver fibrosis inducer) in rats based on its antioxidant, anti-inflammatory, antilipidemic, and anti-fibrotic activities. Ahmed et al [42] reported grape seeds (Vitis vinifera) extract contains flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidins, and the stilbene derivative resveratrol bioactive phytochemicals that possess inhibitory activity on the fat-metabolizing enzymes, pancreatic lipase, and lipoprotein lipase.…”

Section: Weta Et Almentioning

confidence: 99%

Supplementation With 2:1 Ratio of N-6:n-3 Polyunsaturated Fatty Acid Improves Liver Steatosis and Serum Cytokine Levels in Young Obese Balinese Women: A Randomized Clinical Trial

Weta

Mahadewa

Sutirtayasa

et al. 2017

Asian J Pharm Clin Res

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Objectives: In addition to the rise in obesity prevalence globally, morbidity due to nonalcoholic fatty liver disease is increasing. Primary modalities for preventing and managing this problem include dietary modification and improved physical activities. A daily diet with a low n-6:n-3 polyunsaturated fatty acid (PUFA) ratio is suspected to contribute to ameliorating liver steatosis (LS). The present study was conducted to elucidate the effects of an n-6:n-3 PUFA ratio of 2:1 in alleviating LS.Methods: Twenty-four young obese women with LS were recruited from Denpasar, Bali, Indonesia. They were randomly allocated to an intervention or control group. Both groups were given linoleic acid:α-linolenic acid at ratios of 2035:970 and 240:100 g, respectively, for 12 weeks. Baseline and end-line data were obtained. All patients were advised to maintain their daily energy intake no more than 1500 kcal and to perform structured physical exercises once a week. Results:The intervention significantly decreased the body fat (body mass index, p=0.040; triglyceride, p=0.008) and serum tumor necrosis factor-α (TNF-α) levels (p=0.002) and increased serum interleukin-10 (IL-10) levels (p=0.004). The severity of LS was reduced through the intervention (odds ratio=0.064; 95% confidence interval=0.013-0.310; p=0.001).Conclusion: An increased intake of 2:1 n-6:n-3 PUFA ratio alleviated LS, decreased body fat composition and serum TNF-α levels, and increased serum IL-10 levels.

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Ameliorative Effect of Hesperidin on Carbon Tetrachloride Induced Liver Fibrosis in Rats

Cited by 11 publications

References 40 publications

Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

Vitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators

Punica granatum L var nana: A Hepatoprotective and Curative Agent Against CCl4 Induced Hepatotoxicity in Rats

Supplementation With 2:1 Ratio of N-6:n-3 Polyunsaturated Fatty Acid Improves Liver Steatosis and Serum Cytokine Levels in Young Obese Balinese Women: A Randomized Clinical Trial

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