Ameliorative Effect of <i>Ecklonia cava</i> Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

Eo, Hyeyoon; Park, Ji Eun; Jeon, You‐Jin; Lim, Yunsook

doi:10.1021/acs.jafc.7b00357

Cited by 45 publications

(39 citation statements)

References 51 publications

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“…Immoderate fat accumulation causes both oxidative stress and inflammation, which can induce kidney damage in obese subjects. Eo et al ( 2017 ) studied the renal protective effects on high-fat diet obese mice of different dosages of ecklonia cava polyphenol extract given by gavage for 12 weeks, finding that its administration lowered inflammation and oxidative stress. In addition, supplementation with this polyphenol extract significantly up-regulated renal SIRT1, PGC-1α, and AMPK, which are associated with renal energy metabolism, thereby improving the aberrant renal energy metabolism induced by a high-fat diet.…”

Section: Obesity and Diabetesmentioning

confidence: 99%

Flavonoids in Kidney Health and Disease

et al. 2018

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This review summarizes the latest advances in knowledge on the effects of flavonoids on renal function in health and disease. Flavonoids have antihypertensive, antidiabetic, and antiinflammatory effects, among other therapeutic activities. Many of them also exert renoprotective actions that may be of interest in diseases such as glomerulonephritis, diabetic nephropathy, and chemically-induced kidney insufficiency. They affect several renal factors that promote diuresis and natriuresis, which may contribute to their well-known antihypertensive effect. Flavonoids prevent or attenuate the renal injury associated with arterial hypertension, both by decreasing blood pressure and by acting directly on the renal parenchyma. These outcomes derive from their interference with multiple signaling pathways known to produce renal injury and are independent of their blood pressure-lowering effects. Oral administration of flavonoids prevents or ameliorates adverse effects on the kidney of elevated fructose consumption, high fat diet, and types I and 2 diabetes. These compounds attenuate the hyperglycemia-disrupted renal endothelial barrier function, urinary microalbumin excretion, and glomerular hyperfiltration that results from a reduction of podocyte injury, a determinant factor for albuminuria in diabetic nephropathy. Several flavonoids have shown renal protective effects against many nephrotoxic agents that frequently cause acute kidney injury (AKI) or chronic kidney disease (CKD), such as LPS, gentamycin, alcohol, nicotine, lead or cadmium. Flavonoids also improve cisplatin- or methotrexate-induced renal damage, demonstrating important actions in chemotherapy, anticancer and renoprotective effects. A beneficial prophylactic effect of flavonoids has been also observed against AKI induced by surgical procedures such as ischemia/reperfusion (I/R) or cardiopulmonary bypass. In several murine models of CKD, impaired kidney function was significantly improved by the administration of flavonoids from different sources, alone or in combination with stem cells. In humans, cocoa flavanols were found to have vasculoprotective effects in patients on hemodialysis. Moreover, flavonoids develop antitumor activity against renal carcinoma cells with no toxic effects on normal cells, suggesting a potential therapeutic role in patients with renal carcinoma.

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Section: Obesity and Diabetesmentioning

confidence: 99%

Flavonoids in Kidney Health and Disease

et al. 2018

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“…Eo, Park, Jeon, & Lim, found that Ecklonia cava polyphenol extract treatment upregulated renal SIRT1, AMPK, Nrf2, and NQO1 in a model of obesity. FXR preserves normal hepatic metabolism of bile acids, glucose, and lipids, stimulates hepatic regeneration and repair after injury, shields liver cells from death, and stimulates cell survival, preventing inflammatory damage, and tumor genesis.…”

Section: Discussionmentioning

confidence: 99%

“…AMPK and SIRT1 levels in TAA-induced hepatic cirrhosis Di et al (2017). stated that cichoric acid (CA) amplified pAMPK level, activated the nuclear receptor factor-2 (Nrf2), a master regulator of antioxidant enzymes with increasing antioxidant enzymes expression as NQOR1 Eo, Park, Jeon, & Lim, 2017. found that Ecklonia cava polyphenol extract treatment upregulated renal SIRT1, AMPK, Nrf2, and NQO1 in a model of obesity.…”

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confidence: 99%

Mechanistic evaluation of AMPK/SIRT1/FXR signaling axis, inflammation, and redox status in thioacetamide‐induced liver cirrhosis: The role ofCichorium intybuslinn (chicory)‐supplemented diet

et al. 2019

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Liver cirrhosis is a scene profitable to the advance of hepatocellular carcinoma (HCC). The current work was engrossed to weigh the potential role of Cichorium intybus linn against thioacetamide (TAA)‐induced liver cirrhosis and their probable underlying biochemical and molecular mechanisms. farnesoid‐X‐receptor (FXR) expression, proliferating cell nuclear antigen (PCNA) immunoreactivity, and activated AMP protein kinase (pAMPK), sirtuin‐1 (SIRT1), and interleukin‐6 (IL6) levels were estimated in hepatic tissue by real‐time PCR, immunohistochemistry, and immunoassay, respectively. C. intybus linn supplementation caused a significant improvement in serum liver enzymes, albumin, bilirubin levels, tissues redox status and hepatic histological features in addition to decreased IL6 level, hydroxylproline content, and PCNA immunoreactivity. On contrary, increased pAMPK/SIRT1 levels and upregulated FXR gene expression were observed. C. intybus linn could feasibly protect against TAA‐induced hepatic damage, fibrosis, and cirrhosis by relieving oxidative stress and by interruption of the inflammatory pathway via AMPK/SIRT1/FXR signaling. Practical applications No specific therapies are available until now to target the underlying mechanisms for protection against liver diseases. Herbal protection is widely available and cheap with no side effect. Cichorium intybus linn, a natural supplement, is proved in this current work to have the potential of being hepatoprotectant, antioxidant, and anti‐inflammatory agents, thus reducing the risk of hepatic cirrhosis.

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“…[94] However, excessively elevated ROS level would destroy redox balance and give rise to cellular oxidative stress, thus evoking serious damage to biomacromolecules and tissue inflammation. [94] Solid evidences have demonstrated that cellular oxidative stress can cause a variety of diseases, including chronic inflammation, [95] neural dysfunction, [96] atherosclerosis, [97] diabetes, [98] cancer, [99] and cardiovascular diseases. [100] Robust and high-efficient ROS scavengers play critical roles in protecting cells from oxidative stress as they can counteract the detrimental effects induced by excessive ROS and sustain redox balance of the formation and reduction of ROS.…”

Section: Oxidative-stress Cytoprotectionmentioning

confidence: 99%

Single‐Atom Catalysts in Catalytic Biomedicine

2020

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The intrinsic deficiencies of nanoparticle‐initiated catalysis for biomedical applications promote the fast development of alternative versatile theranostic modalities. The catalytic performance and selectivity are the critical issues that are challenging to be augmented and optimized in biological conditions. Single‐atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one of the most explored catalysts in biomedicine recently due to their preeminent catalytic activity and superior selectivity distinct from their nanosized counterparts. Herein, an overview of the pivotal significance of SACs and some underlying critical issues that need to be addressed is provided, with a specific focus on their versatile biomedical applications. Their fabrication strategies, surface engineering, and structural characterizations are discussed briefly. In particular, the catalytic performance of SACs in triggering some representative catalytic reactions for providing the fundamentals of biomedical use is discussed. A sequence of representative paradigms is summarized on the successful construction of SACs for varied biomedical applications (e.g., cancer treatment, wound disinfection, biosensing, and oxidative‐stress cytoprotection) with an emphasis on uncovering the intrinsic catalytic mechanisms and understanding the underlying structure–performance relationships. Finally, opportunities and challenges faced in the future development of SACs‐triggered catalysis for biomedical use are discussed and outlooked.

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Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice

Cited by 45 publications

References 51 publications

Flavonoids in Kidney Health and Disease

Flavonoids in Kidney Health and Disease

Mechanistic evaluation of AMPK/SIRT1/FXR signaling axis, inflammation, and redox status in thioacetamide‐induced liver cirrhosis: The role ofCichorium intybuslinn (chicory)‐supplemented diet

Single‐Atom Catalysts in Catalytic Biomedicine

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