Ameliorative effect of kefir against γ-irradiation induced liver injury in male rats: impact on oxidative stress and inflammation

Ali, Ola; Amin, Nour El-Din; Fattah, Salma M. Abdel; El-Rahman, Omnia Abd

doi:10.1007/s11356-020-09833-7

Cited by 23 publications

(19 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning the radiation effect on liver biomarkers, rats exposed to gamma radiation (7.5 Gy) reveal an increase in the serum alanine transaminase (ALT) (75%) activity, cholesterol (145%) concentration, and triglyceride concentration (TG) (50%), along with a significant decrease in the albumin (32.4%) concentration in comparison with those of control values. These results are in accordance with those of Mekkawy et al 2020 and Sayed et al 2020 [ 41 , 42 ]. They reported that γ–irradiation-induced oxidative stress elevates the permeability of cell membranes and enables the leakage of enzymes outside the cells.…”

Section: Resultssupporting

confidence: 93%

“…They reported that γ–irradiation-induced oxidative stress elevates the permeability of cell membranes and enables the leakage of enzymes outside the cells. In addition, the hyperlipidemic state caused by gamma irradiation could be attributed to the stimulation of cholesterol synthesis by promoting the coenzyme A (HMG-CoA) reductase activity which stimulates cholesterol synthesis [ 42 ]. In addition, as established previously in this study, gamma radiation activates STING, and activation of the STING-interferon 3 pathway (STING-IRF3) triggers hepatocyte damage and dysfunction by increasing IL-6 and TNF-α, thus eliciting inflammation and apoptosis that disturb lipid metabolism [ 6 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition

et al. 2020

View full text Add to dashboard Cite

Exposure to ionizing radiation usually results in cellular oxidative damage and may induce liver toxicity. The efficiency of the ethanol extracts of Washingtonia filifera (EWF) and Washingtonia robusta (EWR) leaves in alleviating γ-radiation-induced oxidative hepatotoxicity was herein explored. Proximate and macronutrient composition of the leaves was determined to establish reliable quality control criteria. Colorimetric estimation of total phenolic (TPC) and flavonoid (TFC) contents revealed their occurrence in larger amounts in EWR. In vitro evaluation of the antioxidant capacity by 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and ferric reducing antioxidant power (FRAP) assays confirmed higher efficiency of EWR designating a close correlation with phenolic composition. Four phenolics, viz., naringenin, kaempferol, quercetin, and gallic acid, were isolated from EWR. In vivo assessment of the extracts’ antioxidant potential was performed on γ-irradiated (7.5 Gy) female rats. EWR was found more efficient in restoring the elevated liver index, ALT, albumin, cholesterol, and reactive oxygen species (ROS) levels. Both extracts ameliorated the increase in the stimulator of interferon gene (STING) expression. Bioactivity was confirmed by immuno-histochemical examination of inflammatory and apoptotic biomarkers (TNF-α, IL-6 and caspase-3) and histopathological architecture. In addition, the interactions of the isolated compounds with STING were assessed in silico by molecular docking. Therefore, Washingtonia robusta leaves might be suggested as a valuable nutritional supplement to alleviate radiotherapy-induced hepatotoxicity.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In acute and chronic murine colitis models, the PRCC-1301 EVs mitigated body weight loss, histological damage, colon shortening, and the reduction of phosphorylated NF-κB p65 and IκBα in colon tissue sections, indicating the potent anti-inflammatory effect of PRCC-1301 EVs in inhibiting the NF-κB pathway and improving intestinal barrier function. Ali et al [127] studied the protective role of kefir in attenuating γ radiation-induced hepatotoxicity. The results from this study demonstrated that kefir treatment had significantly decreased the γ radiation-induced hepatic function impairment, hepatic histological alterations, and dyslipidemia.…”

Section: Anti-inflammationmentioning

confidence: 99%

Kefir and Its Biological Activities

Azizi

Kumar

Yeap

et al. 2021

Foods

133

View full text Add to dashboard Cite

Kefir is a fermented beverage with renowned probiotics that coexist in symbiotic association with other microorganisms in kefir grains. This beverage consumption is associated with a wide array of nutraceutical benefits, including anti-inflammatory, anti-oxidative, anti-cancer, anti-microbial, anti-diabetic, anti-hypertensive, and anti-hypercholesterolemic effects. Moreover, kefir can be adapted into different substrates which allow the production of new functional beverages to provide product diversification. Being safe and inexpensive, there is an immense global interest in kefir’s nutritional potential. Due to their promising benefits, kefir and kefir-like products have a great prospect for commercialization. This manuscript reviews the therapeutic aspects of kefir to date, and potential applications of kefir products in the health and food industries, along with the limitations. The literature reviewed here demonstrates that there is a growing demand for kefir as a functional food owing to a number of health-promoting properties.

show abstract

“…The lipid peroxidation level is estimated by measuring the levels of lipid peroxidation (LPO) [ 37 ], methylenedioxyamphetamine (MDA), 4-hydroxynonenal (4-HNE) [ 30 ], and thiobarbituric acid reactive substance (TBARS) [ 31 ]. Membrane lipid peroxidation can enhance the rigidity of membranes, decrease the activity of membrane-bound enzymes, change membrane receptor activity, and alter membrane permeability [ 15 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

Radiation-induced liver injury and hepatocyte senescence

Zhu

Zhang

et al. 2021

Cell Death Discov.

View full text Add to dashboard Cite

Radiation-induced liver injury (RILI) is a major complication of radiotherapy during treatment for liver cancer and other upper abdominal malignant tumors that has poor pharmacological therapeutic options. A series of pathological changes can be induced by radiation. However, the underlying mechanism of RILI remains unclear. Radiation can induce cell damage via direct energy deposition or reactive free radical generation. Cellular senescence can be observed due to the DNA damage response (DDR) caused by radiation. The senescence-associated secretory phenotype (SASP) secreted from senescent cells can cause chronic inflammation and aggravate liver dysfunction for a long time. Oxidative stress further activates the signaling pathway of the inflammatory response and affects cellular metabolism. miRNAs clearly have differential expression after radiation treatment and take part in RILI development. This review aims to systematically profile the overall mechanism of RILI and the effects of radiation on hepatocyte senescence, laying foundations for the development of new therapies.

show abstract

Ameliorative effect of kefir against γ-irradiation induced liver injury in male rats: impact on oxidative stress and inflammation

Cited by 23 publications

References 62 publications

Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition

Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition

Kefir and Its Biological Activities

Radiation-induced liver injury and hepatocyte senescence

Contact Info

Product

Resources

About