Ameliorative effect of L-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice

Impairment of the Reproductive System and Mating of Male and Female Black Rats Treated with Lambda-Cyhalothrin Bait and Its Field Application

“…In the current study, LCT bait caused a noticeable decrease in body weights of male and female black rats and this might be related to LCT bait toxicity that decreased food intake and absorption via the gastrointestinal tract and also affected food conversion. These results are in parallel with those of (Al Malahi et al, 2022), who revealed that feeding with different concentrations of LCT induced a reduction in body weight of male and female mice and this returned to LCT decreased the dietary intake. Testicular and epididymis weights are an important index of reproductive health.…”

“…The oxidative damage that occurred in the present study after the feeding of LCT bait is supported by the histological changes in the testis and ovary of black rats. These data are in parallel with those of (Al-Sarar et al, 2014;Al Malahi et al, 2022). In our work, LCT bait caused degeneration of the seminiferous tubules and loss of spermatogenic series with coagulation of the luminal content of male rats.…”

“…During epididymal transit, sperm metabolism elevates but is accompanied by exposure to oxidative stress (Dacheux and Dacheux, 2014). These data are in accordance with Al Malahi et al (2022) who reported that LCT caused damage and change in the sperm morphology of albino mice as a result of the destruction of the testicular cells. So in this study, accumulation of LCT bait in the testis induces oxidative stress accelerating the death of spermatogenic cells as well as may associate with sperm abnormalities.…”

Mitigating properties of vitamin E and olive oil on the teratomorphogenic impacts of lambda-cyhalothrin in developing chick embryos

“…Another similar developmental study conducted on chick embryos indicated that pyrethroids such as bifenthrin with multiple fluoridations exhibit high teratogenic potentials and are found to be toxic to various body organs, including kidneys, liver and lungs [21] . Unfortunately, lambda-cyhalothrin has also shown teratogenic and mutagenic potentials in experimental animal studies [4] , [5] , [10] . As LCH is a fluoridated pyrethroid, it was suggested that the teratogenic potential may partially be attributed to multiple fluoridation in its composition [29] .…”

“…A similar study including mosquito fish and zebra fish revealed that lambda-cyhalothrin has potential of causing cytotoxic and genotoxic effects [33] . Additionally, Al Malahi et al [4] ; found that treatment with lambda-cyhalothrin caused damaging or altering the sperm morphology and showed strong teratogenic and mutagenic effects in mice. Very little information is present regarding the effects of lambda-cyhalothrin on birds and no proper evidence is found for accumulation of lambda-cyhalothrin in tissues or eggs of birds [10] .…”