Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1

Adil, Malik M; Kandhare, Amit D.; Ghosh, Pranab; Venkata, Shivakumar; Raygude, Kiran S.; Bodhankar, Subhash L.

doi:10.3109/0886022x.2016.1163998

Cited by 81 publications

(57 citation statements)

References 85 publications

(89 reference statements)

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“…Thus, ANTU‐induced toxicity is also associated with hepatic damage . AST and ALT are the two important hepatic enzymes documented to be elevated during the hepatic injury . In the present investigation, ANTU administration caused a significant elevation in serum AST and ALT levels confirming hepatic damage.…”

Section: Discussionmentioning

confidence: 99%

“…The levels of messenger RNA (mRNA) were analyzed in the lung, pulmonary artery, and RV tissues ( n = 4) using the reverse‐transcriptase polymerase chain reaction (RT‐PCR) approach as described previously . Briefly, single‐stranded complementary DNA was synthesized from 5 µg of total cellular RNA using reverse‐transcriptase (MP Biomedicals India Private Limited, Mumbai, India), as described previously .…”

Section: Methodsmentioning

confidence: 99%

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Chrysin ameliorates ANTU‐induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs

Wang

Zhang

2019

J Biochem & Molecular Tox

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Alpha-naphthylthiourea (ANTU), a rodenticide induces lung toxicity. Chrysin a flavonoid possesses antioxidant, anti-inflammatory, and antihypertensive potential.The aim of this study was to evaluate the efficacy of chrysin against ANTU-induced pulmonary edema (PE) and pulmonary arterial hypertension (PAH) in laboratory rats.Sprague-Dawley rats were used to induce PE (ANTU, 10 mg/kg, ip) and PAH (ANTU, 5 mg/kg, ip, 4 weeks). Animals were treated with chrysin (10, 20, and 40 mg/kg) and various biochemical, molecular, and histological parameters were evaluated. Acute administration of ANTU induces PE revealed by significant (P < 0.05) increase in relative lung weight, pleural effusion volume, lung edema, bronchoalveolar lavage fluid cell counts, total protein, 5-hydroxytryptamine (5-HT), lactate dehydrogenase (LDH), and γ-glutamyl transferase (GGT), whereas pretreatment with chrysin (20 and 40 mg/kg, ip) significantly (P < 0.05) attenuated these ANTU-induced biochemical and histological alterations. Repeated administration of ANTU caused induction of PAH evaluated by significant (P < 0.05) alterations in electrocardiographic, hemodynamic changes, and left ventricular function, whereas chrysin (20 and 40 mg/kg, p.o.) treatment significantly (P < 0.05) attenuated these alterations. ANTU-induced hematological and serum biochemical (aspartate transaminase, alanine transaminase, LDH, and creatinine kinase MB) alterations were significantly (P < 0.05) inhibited by chrysin. It also significantly (P < 0.05) decreased elevated levels of oxido-nitrosative stress in the right ventricle (RV) and lung. Chrysin significantly (P < 0.05) attenuated downregulated endothelial nitric oxide synthase and upregulated vascular endothelial growth factor messenger RNA and protein expressions both in the RV and pulmonary artery. Chrysin inhibited ANTU-induced PE and PAH via modulation of inflammatory responses (5-HT, LDH, and GGT), oxido-nitrosative stress, and VEGF and eNOs levels.K E Y W O R D S alpha-naphthylthiourea, chrysin, eNOs, pulmonary arterial hypertension, pulmonary edema, vascular endothelial growth factor J Biochem Mol Toxicol. 2019;33:e22332.wileyonlinelibrary.com/journal/jbt

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Chrysin ameliorates ANTU‐induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs

Wang

Zhang

2019

J Biochem & Molecular Tox

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“…The levels of mRNA were analyzed in sciatic nerve using a reverse transcription (RT)- Polymerase chain reaction (PCR) approach as described previously (Adil et al, 2016[3], 2014[5]). Single-stranded cDNA was synthesized from 5 µg of total cellular RNA using reverse transcriptase (MP Biomedicals India Private Limited, India) as described previously (Adil et al, 2014[5]; Ketkar et al, 2015[51]).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: evidence from anti-inflammatory, antioxidant and anti-apoptotic studies

Kandhare

Mukherjee

Bodhankar

2017

EXCLI Journal; 16:Doc546; ISSN 1611-2156

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“…The altered serum creatinine level is one of the important clinical features of CIN that has been consistently ob-served in the available body of evidence (18,32). It has been well documented that the increased level of ROS induces mesangial cells contraction and modifies the filtration surface area, resulting in an increased serum creatinine level (33,34). Previous preclinical studies suggested that antioxidant supplementation inhibits free radical damage and thereby decreases GFR and finally inhibits CIN-induced el-6…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Antioxidant Supplements on Prevention and Amelioration of Cisplatin-Induced Nephrotoxicity: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Kandhare

Mukherjee

Bodhankar

2019

Jundishapur J Nat Pharm Prod

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Context: Cisplatin is a widely used antineoplastic agent in the treatment of a wide range of malignancies although it is associated with nephrotoxicity. Much clinical evidence supports the use of antioxidant supplements in the prevention of cisplatin-induced nephrotoxicity (CIN). However, conflicting evidence makes us unable to provide any robust results for antioxidants use against CIN. Objectives:The study aimed to investigate the efficacy of antioxidant supplements on CIN through a comprehensive meta-analysis of randomized controlled trials. Data Sources:A systematic literature search was conducted in PubMed, EMBASE, Cochrane Library, CPCI-S (Conference Proceedings Citation Index-Science), ICTRP (International Clinical Trials Registry Platform), and Google Scholar until February 2017 by two independent researchers. Various outcomes such as serum creatinine, estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), creatinine clearance, and incidence of CIN were assessed. All statistical analyses were performed using RevMan V.5.3 Results:Overall, 672 patients were identified from 10 studies of whom 330 (49.10%) patients received antioxidant treatment. Antioxidant treatment showed a significant reduction in serum creatinine (SMD: -3.40, 95% CI: -5.47 to -1.33, P = 0.001), BUN (SMD = -5.96, 95% CI: -10.07 to -1.86, P = 0.004), and eGFR (SMD = -3.77, 95% CI: -6.16 to -1.38; P = 0.002) when compared to the control group.Conclusions: Antioxidant treatment is associated with a reduced risk of CIN. It also has important clinical implications for CIN patients who are not responding to other therapies such as hydration, diuresis, or magnesium supplementation.

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Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1

Abstract: Naringin exerts its hepato- and nephroprotective effect via modulation of oxido-nitrosative stress, FXR and KIM-1 mRNA expression.

Cited by 81 publications

References 85 publications

Chrysin ameliorates ANTU‐induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs

Chrysin ameliorates ANTU‐induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs

Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: evidence from anti-inflammatory, antioxidant and anti-apoptotic studies

Efficacy of Antioxidant Supplements on Prevention and Amelioration of Cisplatin-Induced Nephrotoxicity: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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