Ameliorative effect of p-coumaric acid, a common dietary phenol, on adjuvant-induced arthritis in rats

Abstract

p-Coumaric acid (3-(4-hydroxyphenyl)-2-propenoic acid), a common dietary polyphenol, is widely distributed in cereals, fruits and vegetables with antioxidant property. Numerous studies have enlightened the ability of dietary phenols to be considered as potential therapeutics against arthritis. In this study, we aimed to investigate the ameliorative effect of plant phenolic p-coumaric acid on adjuvant-induced arthritis in rats. The reference drug indomethacin was used for comparison purposes. Arthritis was induced in rats by a single intradermal injection of complete freund's adjuvant (0.1 mL) into the foot pad of right hind paw. p-Coumaric acid (100 mg/kg b wt) and indomethacin (3 mg/kg b wt) were administered intraperitoneally for 8 days from day 11 to 18 after adjuvant injection. An increase in the activities/levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and paw thickness was observed in the arthritic rats, on the contrary, the body weight was found to be reduced in arthritic rats when compared to normal control rats. Administration of p-coumaric acid (100 mg/kg b wt) to the arthritic rats reverted back the altered physical and biochemical parameters to near normal levels comparable to indomethacin treatment. Histopathological evaluation of ankle joints in arthritic rats also revealed the anti-inflammatory effect of p-coumaric acid by the reduction in leukocytes infiltration. Thus, the present study clearly demonstrates the anti-inflammatory potential of the p-coumaric acid against adjuvant-induced arthritis in rats.

p‐Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model

“…As previous studies have unravelled ameliorative properties such as anti‐ulcer , anti‐microbial , anti‐platelet , anti‐mutagenic , and anti‐inflammatory activities ; making CA an ideal natural compound to elucidate further against RA. Recently, we showed that the anti‐peroxidative and lysosomal membrane‐stabilizing effect of CA in adjuvant‐induced arthritic rats . Here, we validated the anti‐arthritic effect of CA and explored its underlying molecular mechanism in the in‐vivo and in‐vitro model.…”

“…The drugs (1 ml) were administered intraperitoneally on day 11 to day 26 consecutively for 16 days. The dosage of CA was fixed based on the preliminary results . DEXA scan was carried day 0 (before the onset of symptoms), day 11(after the onset of symptoms), and day 27(prior to sacrifice).…”

Bioactivity of Selected Phenolic Acids and Hexane Extracts from Bougainvilla spectabilis and Citharexylum spinosum on the Growth of Pectobacterium carotovorum and Dickeya solani Bacteria: An Opportunity to Save the Environment

“…The hydroxycinnamic (a) and the hydroxybenzoic (b) acids, are two main groups of phenolics; (a) group contains caffeine, ferulic and p-coumaric acids, but the (b) group contains gallic, protocatechic acids [97,98]. p-Coumaric acid is the stepping stone in synthesis process of caffeic, chlorogenic and ferulic acids, and these phenolics lead to have an antimicrobial and antiviral effects in different mode of actions as it could kill the fungal and bacterial cells by breakdowns and ruptures the plasma membrane [99][100][101][102][103]. In another study, the cinnamic acid proved to be effective in suppressing the virulent species of Pectobacterium spp.…”

Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review

“…It is a major precursor in the synthesis of other phenolic acids, such as caffeic, chlorogenic, rosmarinic and ferulic acids. It is widely distributed in fruits, vegetables, cereals and mushrooms [ 22 , 23 ]. Studies on p -coumaric acid and its conjugated forms revealed properties, such as antioxidant, antimicrobial, antitumor, anti-inflammatory, antiplatelet aggregation, as well as other interesting health benefits [ 24 ].…”