Ameliorative effect of propolis against cyclophosphamide-induced toxicity in mice

El‐Naggar, Sabry A.; Alm-Eldeen, Abeer A.; Germoush, Mousa O.; El-Boray, Kamal F.; Elgebaly, Hassan A.

doi:10.3109/13880209.2014.914230

Cited by 54 publications

(37 citation statements)

References 37 publications

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“…Kidney histological examination contributes to diagnostic accuracy in druginduced kidney damage and remains a valuable tool in assessing drug-induced kidney damage (48). CP renal pathology is often characterized by necrotic changes in kidney structure (49). This study observed kidney pathologic changes characterized by tubular necrosis, and infiltrations by inflammatory cells in CP-treated rats.…”

Section: Discussionmentioning

confidence: 69%

Comparative protective assessments of some antioxidants against cyclophosphamide-induced kidney toxicity in albino rats

Adikwu¹,

Nelson²,

Yambozibe³

2019

J Nephropharmacol

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Section: Discussionmentioning

confidence: 69%

Comparative protective assessments of some antioxidants against cyclophosphamide-induced kidney toxicity in albino rats

Adikwu¹,

Nelson²,

Yambozibe³

2019

J Nephropharmacol

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“…Propolis has a long history of being used in traditional medicine (Gavanji & Larki, 2015). Ghisalberti et al (1978) reported that propolis extracts have a broad spectrum of biological activities, namely antioxidant (Nagai et al, 2003;Zhang et al, 2016), antibacterial (Choi et al, 2006), antiviral (Marcucci, 1995;Yildirim et al, 2016) and anticancer (Kumazawa et al, 2004;El-Naggar et al, 2015) due to its related therapeutic compounds including polyphenols and flavonoids. Various molecules have been identified from propolis collected from different parts of the world, including phenolic acids, flavones, flavonols and flavanones.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effects of six Algerian propolis extracts

Boufadi

Soubhye

Nève

et al. 2016

Int J of Food Sci Tech

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Summary This study aimed to study the antimicrobial effect of propolis and determine the essential compounds which give it the antimicrobial activity. The antimicrobial effect was investigated for six ethyl acetate extracts of propolis (EAPs) collected from different regions of Algeria on four pathogenic strains (Shigella dysenteriae, Shigella sonnei, Staphylococcus aureus and Escherichia coli) and two benefit strains (Bifidobacterium animalis and Lactobacillus rhamnosus). The results obtained in this study indicated that the different EAPs showed potential inhibitory effects on tested pathogenic strains with variable minimum inhibitory concentration (MIC) values of 0.3 and 9 mg ml−1, while the beneficial bacteria showed resistance against EAPs of propolis. The results demonstrated also that the flavonoid compounds have very low MIC values, while phenolic acid compounds have variables MIC values of 1–10 mg ml−1. These results indicated that propolis contains proven substances with antimicrobial activity and are a prelude to the investigations aimed at empowerment of the bee substance as a potential source of antimicrobial agents with multiple outlets.

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“…Chemotherapy with cyclophosphamide is known to affect the performance of the immune system, in terms of reduction in the number of WBCs, resulting in increased susceptibility to viral and bacterial infections (El‐Naggar, Alm‐Eldeen, Germoush, El‐Boray, & Elgebaly, ). To determine the success of this model and whether the mixture of polysaccharides and polyphenols enhances immunity, we evaluated the population of peripheral blood WBCs in mice.…”

Section: Resultsmentioning

confidence: 99%

A Mixture of Functional Complex Extracts from Lycium barbarum and Grape Seed Enhances Immunity Synergistically In Vitro and In Vivo

You

Chang

Zhao

et al. 2019

Journal of Food Science

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A mixture of multiple ingredients is often more effective than the individual ingredients. The functions of Lycium barbarum polysaccharide (LBP) glycoconjugate and grape seed procyanidins (GSP) are widely known. Here, we investigated the synergistic immune‐enhancing activity of LBP and GSP. Atomic force microscopy results suggested that the mixture of LBP and GSP exhibited circular structure unlike LBP alone, and the addition of polyphenols may change the spatial conformation of the sugar chain. The changes in the structure were related to the synergistic effect of the two functional agents on immune recovery. In vitro, the proliferation rate of splenocytes was higher in LBP + GSP group (64.16%), rather than the sum of LBP group (13.01%) and GSP group (43.61%) individually used. This synergistical proliferation of splenocytes may be correlated to the increasing intracellular free calcium levels. Furthermore, the mixture significantly enhanced the immunity in vivo, as evident from the recovery of peripheral white blood cell counts in LBP + GSP group (18.535 × 109/L) to normal group levels (18.115 × 109/L) and higher B cell proliferation than normal group (P < 0.05). These results highlight the immune‐enhancing activity of the combination of LBP and GSP associated with the structural changes, which may facilitate the development of functional foods with fewer resources but enhanced activities. Practical Application The synergistic effects of LBP and GSP on immunomodulatory were better than the sum of the effects of the individual agents both in vitro and in vivo. Our results may provide a research‐based support for the development of related functional products and an insight into the production of food resources with a fewer but more effective functional agents for better results.

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Ameliorative effect of propolis against cyclophosphamide-induced toxicity in mice

Abstract: In conclusion, propolis might be considered an effective agent in ameliorating the toxicity resulted from CTX treatment.

Cited by 54 publications

References 37 publications

Comparative protective assessments of some antioxidants against cyclophosphamide-induced kidney toxicity in albino rats

Comparative protective assessments of some antioxidants against cyclophosphamide-induced kidney toxicity in albino rats

Antimicrobial effects of six Algerian propolis extracts

A Mixture of Functional Complex Extracts from Lycium barbarum and Grape Seed Enhances Immunity Synergistically In Vitro and In Vivo

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