Ameliorative effect of purple bamboo salt-pharmaceutical acupuncture on cisplatin-induced ototoxicity

Myung, Noh-Yil; Choi, In-Hwa; Jeong, Hyun‐Ja; Kim, Hyung-Min

doi:10.3109/00016489.2010.514286

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…l ‐carnitine and its acyl esters have reactive oxygen scavenger function and immunomodulatory features in mammalian and avian species . Here, CDDP has been shown to induce production of pro‐inflammatory cytokines IL‐6, TNF‐α and IL‐1β in HEI‐OC1 cells, similar to previous studies . Pro‐inflammatory cytokine secretion is one cell death mechanism of cisplatin‐induced ototoxicity, demonstrated both in vitro and in vivo ( ) .…”

Section: Discussionsupporting

confidence: 86%

“…One of these is formation of DNA adducts , and another involves reactive oxygen species generation . Pro‐inflammatory cytokine secretion is also linked to ototoxic effects of CDDP , and all these cytotoxic mechanisms are associated with apoptotic or necrotic cell death . Thus, it is very important to analyse the apoptotic mechanism of CDDP activation and possible protective agents against it.…”

Section: Discussionmentioning

confidence: 99%

“…Kalinec et al . have reported that l ‐carnitine supplementation prevents gentamicin‐induced outer hair cell damage through mitochondrial pathways . ALC has a cell stress modulator function in different cell process, and might have protective functions against chemotherapy‐induced neurotoxicity .…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of acetyl‐l‐carnitine against cisplatin ototoxicity: role of apoptosis‐related genes and pro‐inflammatory cytokines

et al. 2013

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Protective mechanisms of aceytl-L-carnitine against cisplatin induced apoptosis, mainly due to activation of anti-apoptotic Bcl family members' genes, and in an Akt-related gene expression dependent manner. This is the first study to indicate that acetyl-L-carnitine can be an effective agent against cisplatin ototoxicity in auditory cells, with induction of anti-apoptotic gene expression and attenuating levels of pro-inflammatory cytokines.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Protective effect of acetyl‐l‐carnitine against cisplatin ototoxicity: role of apoptosis‐related genes and pro‐inflammatory cytokines

et al. 2013

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“…However, the mechanism behind these protective effects is not clear. To date, most studies examining this issue have focused on the effects of acupuncture on the inner ear and cochlear spiral ganglion [ 8 – 10 ]. To the best of our knowledge, it has not been reported whether the auditory benefits of acupuncture involve the auditory nuclei.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Acupuncture Against Gentamicin-Induced Ototoxicity in Rats: Possible Role of Neurotrophin-3

Zhou

Sheng

et al. 2017

Med Sci Monit

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Background:The aim of this study was to investigate the protective effects of acupuncture against gentamicin-induced ototoxicity and explore the possible protective role of neurotrophin-3 (NT-3). Material/Methods:Twenty-four rats were divided randomly into 4 groups: control group, gentamicin group, neitinggong group, and tinggong group. Rats in the gentamicin, neitinggong, and tinggong groups received intraperitoneal injection of gentamicin (100 mg/kg) for 14 consecutive days. Rats in the neitinggong and tinggong groups further received acupuncture at neitinggong or tinggong acupoints once every 2 days for 20 days. Rats in the control group received intraperitoneal injection of saline. Auditory brainstem response (ABR) was tested in all rats on the day before treatment (day 0), and again on day 14 and day 20 to determine the average threshold value of ABR for each treatment group. The expression of NT-3 in the cochlear nucleus and the inferior colliculus nucleus were detected by immunohistochemical staining. Results:The average threshold value of ABR was significantly higher in the gentamicin group as compared with that of the control group on day 14 (P<0.05). On day 20, the average threshold values of ABR in the neitinggong and tinggong groups were significantly lower than that of the gentamicin group (P<0.05). No statistically significant differences in NT-3 expression in the cochlear nucleus were observed among the groups (P>0.05). However, the expression of NT-3 in the inferior colliculus nucleus in both the neitinggong and tinggong groups was significantly higher than that of the gentamicin group (P<0.01). Conclusions:A decrease in NT-3 expression in the inferior colliculus nucleus may contribute to gentamicin-induced ototoxicity in rats. Acupuncture at neitinggong or tinggong acupoints effectively improved hearing, which was attributed partially to the rescue of NT-3 expression in the inferior colliculus nucleus. Therefore, preserving NT-3 expression in the auditory system may be a viable strategy to counteract gentamicin-induced ototoxicity.

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“…compared with those of SDS, were changed (Shin et al, 2004). Though it is just small difference in the total portion of salts, PBS is reported to have therapeutic effects for diseases such as viral diseases, dental plaque, gastropathy, diabetes, circulatory organ disorders, cancer, anti-inflammatory disorders, allergic rhinitis, and cisplatin-induced ototoxicity (Min et al, 1995;Shin et al, 2004;Yang et al, 1999;Huh et al, 2001;Sharma et al, 2001;Myung et al, 2011;Jeong et al, 2011;Kim et al, 2012). Nowadays, inflammation is considered important in the cause of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Surprisingly, traditional purple bamboo salt, unlike other salts does not induce hypertension in rats

Kim¹,

Lee²,

Kim³

2013

TANG [HUMANITAS MEDICINE]

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Hypertension induces many of the social costs related by cardiovascular diseases. Sodium is known as a crucial factor in inducing type I hypertension. In traditional Korean medicine, bamboo salt (BS) has been used in the attenuation of salts toxic coldness and nowadays it has shown various therapeutic effects. It contains mostly sodium chloride (about 91.7% of BS); however, the effect of BS on hypertension is still not completely understood. Thus, we investigated the effect of BS on blood pressure for the first time. Two group of BS, sun-dried salt (SDS), NaCl, or distilled water (DW, vehicle control) was administrated orally for 8 weeks. Although BS had no effect on body weight and food intake, it increased water intake (p < 0.05). The BS groups, in terms of blood pressure, was similar to the DW group; whereas the SDS and NaCl groups showed significantly increased blood pressure levels (p < 0.05). BS also decreased sodium-chloride cotransporter (NCC) mRNA expression, unlike SDS or NaCl. These observations indicate that BS may be a promising strategy for the prevention of various diseases including salt-related diseases.

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Ameliorative effect of purple bamboo salt-pharmaceutical acupuncture on cisplatin-induced ototoxicity

Cited by 8 publications

References 21 publications

Protective effect of acetyl‐l‐carnitine against cisplatin ototoxicity: role of apoptosis‐related genes and pro‐inflammatory cytokines

Protective effect of acetyl‐l‐carnitine against cisplatin ototoxicity: role of apoptosis‐related genes and pro‐inflammatory cytokines

Protective Effects of Acupuncture Against Gentamicin-Induced Ototoxicity in Rats: Possible Role of Neurotrophin-3

Surprisingly, traditional purple bamboo salt, unlike other salts does not induce hypertension in rats

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