Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross‐link between XBP‐1/PPAR‐1, regulatory proteins for lipogenesis/steroids

Abstract

Polycystic ovary syndrome (PCOS) is a mixed endocrine/metabolic/reproductive disorder in women of reproductive age. Sesame oil (SO) contains sesame lignans & vitamin E with broad-spectrum antioxidant and anti-inflammatory effects. This study investigates the ameliorative effect of SO on experimentally induced PCOS and elucidates the possible molecular mechanisms with a deeper focus on the different signaling pathways involved.The study was carried out on 28 nonpregnant female Wister albino rats that were divided into four equal groups; Group I (control group) received oral 0.5% wt/vol carboxymethyl cellulose daily. Group II (SO group): orally administered SO (2 mL/kg body wt./day) for 21 days. Group III (PCOS group) received letrozole daily, 1 mg/kg, for 21 days. Group IV (PCOS + SO group): concomitantly administered letrozole and SO for 21 days. The serum hormonal and metabolic panel and the homogenate ATF-1, StAR, MAPK, PKA, and PI3K levels of the ovarian tissue were calorimetrically evaluated. However, endoplasmic

Ameliorative potential of rosmarinic acid in a rat model of polycystic ovary syndrome: Targeting MCP‐1 and VEGF: A histological, immunohistochemical, and biochemical study

“…Also, the microscopic examination of the ovarian cortex of PCOS rats revealed multiple cystic follicles in the ovarian cortex with markedly thin granulosa cell layer, vacuolated granulosa and theca cell layers, and desquamated granulosa cells. These findings followed several publications which reported that administering letrozole to female adult rats can cause PCOS similar to those seen in humans 6,34,35 …”

“…These findings followed several publications which reported that administering letrozole to female adult rats can cause PCOS similar to those seen in humans. 6,34,35 One fundamental aspect of PCOS is the disruption of steroid hormones. LH pulse frequency increases with high testosterone in female PCOS patients.…”

“…As a result, letrozole has primarily been administered postnatally to create animal models of PCOS that exhibit numerous features of human PCOS. 5,6 Owing to increased androgen exposure, females with PCOS had been shown to have hypertrophic adipocytes. Inflammation was more prone to strike hypertrophic adipocytes.…”

“…This can lead to hormonal imbalances, including hyperandrogenism, aberrant follicular development, immaturity, anovulation, polycystic ovaries, hyperinsulinemia, glucose intolerance, insulin resistance, and obesity. As a result, letrozole has primarily been administered postnatally to create animal models of PCOS that exhibit numerous features of human PCOS 5,6 …”

Daily supplement of sesame oil prevents postmenopausal osteoporosis via maintaining serum estrogen and aromatase levels in rats

“…Inhibition of aromatase activity in non-pregnant female rats is a well-established animal model for polycystic ovary syndrome (PCOS). The protective effects of sesame oil on these rats are mediated by the amelioration of regulatory proteins for ER stress, lipogenesis, and steroidogenesis through the PI3K/PKA or MAPK/ERK2 signaling pathway 29 . Therefore, the associations between the PI3K/PKA or MAPK/ERK2 pathway and aromatase level may be involved in the therapeutic effects of sesame oil on female-dominant diseases.…”