Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease

Khurana, Navneet; Gajbhiye, Asmita

doi:10.1016/j.neuro.2013.08.005

Cited by 75 publications

(41 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Siddique et al [125] reported that epicatechin gallate dietary supplementation reduced the oxidative stress and apoptosis in the brain of transgenic Drosophila model of PD. Khurana and Gajbhiye [126] showed the ameliorative effect of Sida cordifolia against rotenone-induced oxidative stress and neurochemical and behavioral alterations in a rat model of PD. Chandran and Muralidhara [127] showed the neuroprotective effect of aqueous extract of Selaginella delicatula in a chronic ROT exposure model of neurotoxicity in mice.…”

Section: Natural Products and Parkinson's Diseasementioning

confidence: 99%

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Manoharan

Guillemin

Abiramasundari

et al. 2016

Oxidative Medicine and Cellular Longevity

418

289

View full text Add to dashboard Cite

Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer's disease (AD), impairments in the movement, Parkinson's disease (PD), and the inability to walk, talk, and think, Huntington's disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.

show abstract

Section: Natural Products and Parkinson's Diseasementioning

confidence: 99%

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Manoharan

Guillemin

Abiramasundari

et al. 2016

Oxidative Medicine and Cellular Longevity

418

289

View full text Add to dashboard Cite

show abstract

“…The HFSC and CFSC co-treatment failed to show significant attenuation of rotenone-induced damage. These results indicated the possible therapeutic potential of the most polar fraction of AESC, i.e., AFSC in Parkinson's disease by virtue of its antioxidative actions [19].…”

Section: Activity Against Parkinson's Diseasementioning

confidence: 76%

“…In another study conducted by Khurana and Gajbhiye [19], ameliorative effect of S. cordifolia in rotenone-induced oxidative stress model of Parkinson's disease has been evaluated. In this study, they evaluated the effect of AESC and its different fractions; hexane (HFSC), chloroform (CFSC) and aqueous (AFSC), against rotenone-induced biochemical, neurochemical, histopathological and behavioral alterations in a rat model of Parkinson's disease.…”

Section: Activity Against Parkinson's Diseasementioning

confidence: 99%

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

Khurana

Sharma

Patil

et al. 2016

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

Plants have been considered to be useful as a medicine for treating different ailments and improving health conditions, since ancient times. The plants as herbal drugs lay down an important foundation of different, well recognized, ancient, and traditional healthcare systems in India as well as other parts of the world. In India, plants constitute an important and indispensable role in different ancient healthcare systems such as Ayurveda, Siddha, Unani, Naturopathy, and Homeopathy. In Ayurveda system of medicine, one of the Rasayana plants having a great medicinal importance is Sida cordifolia belonging to the family Malvaceae. It is an annual undershrub found throughout the tropical and subtropical regions of India. It has been used since ancient times for various ailments in Ayurveda system of medicine. It has numerous folklore uses in different pathological conditions. The plant also reported to possess a number of important pharmacological activities. The present review focused on all these folklore use of this herb along with its reported pharmacological activities.

show abstract

“…This plant is already reported to have significant in vitro and ex vivo antioxidant property [10], anti-inflammatory and lipid lowering activities [11]. Besides, it is reported to be useful in the various nervous disorders such as unilateral paralysis, facial palsy [12], and Parkinson's disease [13][14][15][16] as mentioned in the Ayurvedic literature. These related activities reported for this plant suggests the evaluation of this plant for this debilitating condition of dementia.…”

Section: S Cordifolia L (Family Malvaceae)mentioning

confidence: 99%

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Khurana

Sharma

Patil

et al. 2017

Asian J Pharm Clin Res

Self Cite

View full text Add to dashboard Cite

Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC, respectively) was evaluated against scopolamine (Sco)-induced amnesia in mice. S. cordifolia L. is a well-know Ayurvedic plant which has been administered anciently for various nervous disorders including loss of memory. Female Swiss albino mice were used for Sco-induced amnesia model and acute toxicity study.Methods: Acute toxicity study was carried out to select safe and effective doses (50, 100 and 250 mg/kg; p.o.) of AESC and EESC for further pharmacological evaluation. The AESC and EESC at selected doses and donepezil (Dpl) (5 mg/kg; p.o.) were administered to different groups for consecutive 15 days. On 15 th day of treatment, Sco (0.4 mg/kg, intraperitoneally) was administered to different groups for induction of amnesia. Mice were subjected to transfer latency (TL) and step down latency (SDL) tests on the 16 th day to evaluate the effect of AESC and EESC on memory.Results: Sco treatment caused a significant increase in TL and decrease in SDL. The EESC significantly and dose dependently reversed the Sco-induced amnesia. The maximum effect was seen in EESC (100 mg/kg) treated group. This effect of EESC was comparable to the group treated with Dpl. The group treated with varying doses of AESC showed no significant effect on TL and SDL. Conclusion:These findings suggested the possible therapeutic potential of EESC (70%) for diseases related to memory dysfunctions like dementia in Alzheimer's disease.

show abstract

Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease

Cited by 75 publications

References 36 publications

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Contact Info

Product

Resources

About