Ameliorative effect of statin therapy on oxidative damage in heart tissue of hypercholesterolemic rabbits

Sözer, Volkan

doi:10.1111/fcp.12144

Cited by 7 publications

(5 citation statements)

References 48 publications

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“…However, the pretreatment of rats with atorvastatin attenuated testosterone-induced MDA generation and enhanced GSH and SOD activity. This finding corroborates the report of antioxidant property of atorvastatin in heart tissues [35]. In contrast, pretreatment of rats with celecoxib or pioglitazone failed to enhance the antioxidant enzyme activity in the prostate compared with vehicle-testosterone-treated.…”

Section: Discussionsupporting

confidence: 91%

Atorvastatin attenuates testosterone‐induced benign prostatic hyperplasia in rats: role of peroxisome proliferator‐activated receptor‐γ and cyclo‐oxygenase‐2

Ishola

Tijani

Dosumu

et al. 2017

Fundamemntal Clinical Pharma

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Diabetes and obesity have been reported to alter sex steroid hormone metabolism. In this study, an attempt was made to investigate the protective effect of atorvastatin (ATR) in combination with celecoxib (CEL) or pioglitazone (PIO) on testosterone-induced BPH in rats. Male Wistar rats (200-250 g) were randomly divided into nine groups (n = 8) and orally treated as follows for 28 consecutive days: group 1: vehicle control (10 mL/kg); group 2: vehicle testosterone (10 mL/kg); groups 3 - 5: ATR (0.5, 2.5, and 5 mg/kg, respectively); group 6: CEL (20 mg/kg); group 7: PIO (20 mg/kg); and groups 8-9: ATR 0.5 mg/kg, and 15 min later, animals were given CEL (20 mg/kg) or PIO (20 mg/kg), respectively. One hour post-treatment, animals in groups 2-9 were given testosterone propionate (3 mg/kg, s.c.). Twenty-four hours after last treatment on day 28, blood was collected for serum testosterone and prostate-specific antigen (PSA) analysis. Prostate was harvested for biochemical and histological assays. Subcutaneous injection of testosterone increased serum levels of testosterone and PSA which was ameliorated by pretreatments of rat with ATR, celecoxib, or pioglitazone. Similarly, testosterone-induced increase in MDA and reduction in the activity of GSH, superoxide dismutase (SOD), and catalase were attenuated by ATR. Conversely, celecoxib or pioglitazone treatment failed to affect the activity of antioxidant enzymes. The histology of the prostate showed significant improvement in prostatic cells of ATR, celecoxib, or pioglitazone treated. Findings from the study showed that atorvastatin attenuated testosterone-induced BPH. Moreover, synergistic effect was observed when atorvastatin was combined with celecoxib.

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Section: Discussionsupporting

confidence: 91%

Atorvastatin attenuates testosterone‐induced benign prostatic hyperplasia in rats: role of peroxisome proliferator‐activated receptor‐γ and cyclo‐oxygenase‐2

Ishola

Tijani

Dosumu

et al. 2017

Fundamemntal Clinical Pharma

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“…Interestingly, similar to tamoxifen, administration of simvastatin was associated with an increase in PON1 activity in serum of mice of D2 group. Consistent with this finding, Sozer et al showed that atorvastatin can increase PON1 activity in hypercholesterolemic rabbits, the same effect has also been shown in dyslipidemic patients . Although we did not evaluate the mechanism for the increase in PON1 activity in our study, it has been shown that simvastatin can modulate gene expression of this enzyme .…”

Section: Discussionsupporting

confidence: 89%

Therapeutic effect of simvastatin on DMBA‐induced breast cancer in mice

Karimi

Ashrafi

Shomali

et al. 2018

Fundamemntal Clinical Pharma

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Preclinical studies have shown positive effects of statins against specific cancers. This study aimed to determine the therapeutic effect of simvastatin in 12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer. Female albino mice were divided into two groups, with or without DMBA administration. After tumor appearance, DMBA-treated group was further divided into four groups (D1-D4) as control (D1), treated with simvastatin at 80 and 40 mg/kg/day, orally (D2 and D3) and tamoxifen (50 mg/kg/day, orally) treated group (D4). After 4 weeks, animals were sacrificed, serum samples were collected and tumors were dissected for histopathological study and determination of selected parameters. The tumor marker carcinoma antigen 15-3 (CA15-3), oxidative stress parameters and prostaglandin E2 (PGE2) levels were analyzed in serum and tumors in experimental groups. Tamoxifen and high dose of simvastatin improved parameters of mammary carcinogenesis including mean tumor volume, body weight and percent of mortality as compared to mice with breast tumors without treatment (D1). Additionally, simvastatin usage increased total antioxidant capacity (TAC) level, paraoxonase 1 (PON1) activity in serum and decreased total oxidant status (TOS) and malondialdehyde (MDA) levels in tumors similar to tamoxifen. No significant decrease was found in serum CA 15-3 and tumor PGE2 levels in simvastatin and tamoxifen treated groups as compared to D1 group. These data suggest that simvastatin has anticancer effects which are relatively similar to that of tamoxifen in an animal model of breast cancer.

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“…Despite the increased GSH content in the heart of hypercholesterolemic mice, this improvement in antioxidant defense did not translate into a decrease in oxidative damage, as evidenced by a trend of increasing carbonyl levels in cardiac tissue of mice fed a high cholesterol diet. This finding agrees with previous studies, in which animals with dietinduced hypercholesterolemia exhibit high carbonyl levels in heart tissue (Sozen et al 2018, Sozer 2015. Hypercholesterolemia was also related to increased oxidative damage to lipids (AlSaad et al 2020, Sozer 2015 and DNA (Chtourou et al 2015) in cardiac tissue.…”

Section: Impact Of Hypercholesterolemic Diet and Aunp Treatment On Ox...supporting

confidence: 92%

“…Hypercholesterolemia was also related to increased oxidative damage to lipids (AlSaad et al 2020, Sozer 2015 and DNA (Chtourou et al 2015) in cardiac tissue. Of particular interest, some of these negative effects of hypercholesterolemia on oxidative stress have been prevented by treatment with substances with antioxidant properties (AlSaad et al 2020, Sozer 2015, Chtourou et al 2015.…”

Section: Impact Of Hypercholesterolemic Diet and Aunp Treatment On Ox...mentioning

confidence: 99%

Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues

Rodrigues

Martins

Paula

et al. 2022

An. Acad. Bras. Ciênc.

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Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver's superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue.Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice's liver and heart, which was partially prevented by AuNP treatment.

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Ameliorative effect of statin therapy on oxidative damage in heart tissue of hypercholesterolemic rabbits

Cited by 7 publications

References 48 publications

Atorvastatin attenuates testosterone‐induced benign prostatic hyperplasia in rats: role of peroxisome proliferator‐activated receptor‐γ and cyclo‐oxygenase‐2

Atorvastatin attenuates testosterone‐induced benign prostatic hyperplasia in rats: role of peroxisome proliferator‐activated receptor‐γ and cyclo‐oxygenase‐2

Therapeutic effect of simvastatin on DMBA‐induced breast cancer in mice

Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues

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