Ameliorative Effect of Thymoquinone on Ovalbumin-induced Allergic Conjunctivitis in Balb/c Mice

Hayat, Khizar; Asim, Mohammad; Nawaz, Muhammad; Li, Miao; Zhang, Lin; Sun, Ning

doi:10.3109/02713683.2011.573898

Cited by 26 publications

(20 citation statements)

References 29 publications

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“…In a study that implemented TQ application in conjunctivitis treatment, it was reported that, in addition to other immunity parameters, Ig E level decreased as well (Hayat et al, 2011). Anti-inflammatory properties of TQ on rats with asthma were proven by demonstrating its detractive effect on serum Ig E (Ammar et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

The Serum Protein Fractions in Thymoquinone Treated Rats

Güllü¹,

Dede²

2016

Afr J Tradit Complement Altern Med

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Background: TQ has been used as treatment and preventive agent for many diseases over the years. The goal of this study was to investigate the effects of TQ supplement on fractions of serum proteins. Materials and methods: Fourteen male Wistar-Albino rats (200-250 g weight) were used as material for two groups; (control (C) and thymoquinone (TQ) respectively. Each group contained seven rats. The control group had only corn oil, while the TQ group was dissolved in corn oil. 30 mg/kg/day were given by oral gavage for four weeks. The serum protein fractions were identified using cellulose acetate technique. Results: The total protein level and albumin, α-1, α-2 fractions and A/G ratio have showed no difference between groups (p>0.05). β-globulin fractions of TQ group were higher than control's (p<0.05). In addition, it was observed that the γ-globulin levels of TQ group were lower than that of the control group's (p<0.05). Conclusion: From the results, it was observed that the changes of these fractions may have originated from elevation or decline synthesis, or activities of containing proteins.

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Section: Resultsmentioning

confidence: 99%

The Serum Protein Fractions in Thymoquinone Treated Rats

Güllü¹,

Dede²

2016

Afr J Tradit Complement Altern Med

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“…The important function of oxidative stress in the pathophysiological process of liver injury and fibrosis induced by biliary occlusion is one of the most studied aspects of cholestatic liver injury treatment (Khorasani et al, 2008;Hayat et al, 2011). Previous studies (LaLonde et al, 1997;Konishi et al, 2006;Nagi et al, 2010) show that model rats with bile duct ligation have pathological features similar to those of human cholestatic liver injury.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of thymoquinone on cholestatic rats with liver injury

Kong

Yang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the protective effects of thymoquinone treatment on cholestatic rats with liver injury. Thirty-two Sprague-Dawley rats were divided randomly into four groups: normal control, bile duct ligation model control, low-dose thymoquinone (25 mg/kg), and high-dose thymoquinone (50 mg/kg). Thymoquinone gavage was administered continuously 3 days before bile duct ligation, and saline, at the same volume, was administered to the control group. The rats were sacrificed after 2 weeks of treatment, and the liver tissues were obtained and frozen. The contents of hydroxyproline (HP), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the homogenate of the liver tissues were determined to evaluate the changes in hepatic tissue pathology by fibrosis scoring. The HP and MDA levels were significantly lower and the SOD and GPx levels were significantly higher in the thymoquinonetreatment group than the corresponding levels in the model control (2015) group, and the differences were statistically significant (P < 0.05) and dose-dependent. The hepatic necrosis areas and hepatic fibrosis scores of the thymoquinone-treatment groups were significantly lower than those of the model group (P < 0.05). Thymoquinone increased the antioxidative capacity of liver and reduced the oxidative stress damage to the liver. Thymoquinone can be used as a liver protectant in patients with cholestasis.

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“…No earlier work evaluated the effect of thymoquinone in allergic rhinitis, but a few studies on its effects on other allergic diseases have been published [8,9,10,11,12]. Besides, thymoquinone has a very low toxicity, and a few cases of contact dermatitis have been reported after its use; otherwise, no adverse effects are listed [21].…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have shown that thymoquinone exerts anti-inflammatory effects in patients with certain allergic diseases, including asthma, food allergies, and allergic conjunctivitis [8,9,10,11,12], but its effect on allergic rhinitis remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model

Yurttaş

Şereflican

Erkoçoğlu³

et al. 2016

ORL

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Background/Aims: In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. Methods: A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group 2 underwent ovalbumin (OVA) sensitization only. Group 3 was the study group; after OVA sensitization, the rabbits were treated with intranasal thymoquinone. The group 4 rabbits received mometasone furoate for 7 days after OVA sensitization. Mucosal structures were stained with hematoxylin and eosin, while toluidine blue was used to stain mast cells. Apoptosis was evaluated using a TUNEL assay. Results: In the positive control groups, including the thymoquinone and intranasal mometasone furoate groups, intraepithelial and submucosal inflammation and goblet cell hypertrophy were significantly decreased compared to group 2 (p < 0.001). The cilial structure was normal, as was the chondrocyte structure in both treatment groups. Conclusion: This is the first study to evaluate the histopathological effects of thymoquinone in an allergic rhinitis model. Thymoquinone reduced allergic inflammation and may be valuable for treating allergic rhinitis. However, additional studies are needed.

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Ameliorative Effect of Thymoquinone on Ovalbumin-induced Allergic Conjunctivitis in Balb/c Mice

Abstract: Administration of TQ significantly reduced the ocular symptoms in AC by attenuating the recruitment of eosinophils, level of IgE, histamine and cytokines. Our findings suggest that TQ might be a useful intimation for the treatment and future research for AC.

Cited by 26 publications

References 29 publications

The Serum Protein Fractions in Thymoquinone Treated Rats

The Serum Protein Fractions in Thymoquinone Treated Rats

Protective effect of thymoquinone on cholestatic rats with liver injury

Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model

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