Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys of wistar rats against sodium fluoride induced oxidative stress

Khan, Mohammad Umar; Basist, Parakh; Gaurav,; Zahiruddin, Sultan; Penumallu, Naveen Reddy; Ahmad, Sayeed

doi:10.1016/j.jep.2023.116900

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…For this reason, maintaining a healthy liver is essential. Ayurvedic liver tonics is recommended to maintain optimal liver health Khan et al (2024). However, it has been shown that practically every commercially available liver tonic has antioxidant, antibacterial, and anti-inflammatory qualities Shakya et al (2022), Abbas et al (2023).…”

Section: Liver Tonicmentioning

confidence: 99%

Ameliorative Effect of Polyherbal Formulation for Restoring Liver Health: A Systematic Review

Darbar,

Agarwal,

Saha

et al. 2024

J. Ayu. Her. Integr. Med.

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Herbal medicines have been used for a wide range of ailments since ancient times. Two methods are used in Ayurvedic medicine formulation: one involves employing a single herbal preparation, or multiple combinations of them. Polyherbal formulation is the term for the later. Combining different herbs and plants to treat different medical diseases or to enhance general health is known as polyherbal medicine. Many civilizations all over the world have been using this kind of traditional medicine for centuries, and it is still commonly used today. Due to the active phytoconstituents found in single herbs, which are typically present in minute amounts and occasionally insufficient to produce the desired therapeutic effects, multi herb formulations have a well-established track record. According to scientific research, combining these plants with different potencies may theoretically result in a greater effect than using each plant alone or the sum of their individual effects. Positive interactions between herbs can therefore produce synergistic effect, which may take the form of pharmacokinetic or pharmacodynamic synergism. The great efficacy of polyherbal formulations in treating a wide range of illnesses accounts for their popularity. The growing demand of polyherbal formulations necessitates further scientific investigation in this area.

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Section: Liver Tonicmentioning

confidence: 99%

Ameliorative Effect of Polyherbal Formulation for Restoring Liver Health: A Systematic Review

Darbar,

Agarwal,

Saha

et al. 2024

J. Ayu. Her. Integr. Med.

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“…Chicory ( Cichorium intybus L.) is popularly used for liver disorders ( Faraji et al, 2020 ). A poly-herbal compound is available in the market with the name Sharbat-e-Bazori ( Khan et al, 2024 ), obtained from its seeds and roots, along with other herbs such as Foeniculum vulgare seeds and root, and seeds of Cucumis melo var . utilissimus , C. sativa , and Tribulus terrestris ( Hayat et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Siddiqa,

Qureshi,

Raja

et al. 2024

Front. Pharmacol.

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Background: Liver disease is a serious health concern in today’s world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure.Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat’s liver.Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20 mg/kg of body weight), fourth group (CCl4+chicory) (1.75 mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35 mg/kg), sixth group (CCl4 + chicory of 3.25 mg/kg), seventh group (CCl4 +AgNPs 1.75 mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35 mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25 mg/kg of b. wt.). Blood samples were taken 24 h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed.Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25 mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters.Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.

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“…Medicinal plants have been an essential part of traditional medicine systems worldwide for centuries. These plants contain a wide array of bioactive compounds, such as alkaloids, flavonoids, terpenoids, and polyphenols, which exert therapeutic effects through interactions with specific molecular targets [7,8]. However, elucidating the intricate relationships between these compounds and their targets has proven challenging [2].…”

Section: Introductionmentioning

confidence: 99%

“…Unlike singletarget drugs, many diseases involve a network of interconnected molecular pathways. Medicinal plants, with their multiple bioactive components, can influence multiple points within these networks, providing a holistic approach to treatment [3,7,11,12]. In a recent study conducted on network pharmacological based exploration of therapeutic targets of Boerhaavia diffusa and Tinospora cordifolia herbal combination in chronic kidney disease, it has been reported that the major constituents of these plants such as quercetin, ferulic acid, gallic acid, ameliorates the different pathophysiological targets in treatment of kidney disease [4].…”

Section: Introductionmentioning

confidence: 99%

Advancement of Network Pharmacology in Multi-targeted Therapeutic Evaluation of Medicinal Plants

Gautam

2023

JCRP

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In recent years, network pharmacology has emerged as a powerful approach for understanding the complex interactions between various bioactive components of medicinal plants and their targets within biological systems [1,2]. This approach plays a pivotal role in evaluating the multi-targeted therapeutic potential of medicinal plants, making it a promising tool for drug discovery and development. The integration of traditional knowledge with modern analytical techniques and computational methods has enabled the comprehensive exploration of the pharmacological properties of medicinal plants [3-6]. Medicinal plants have been an essential part of traditional medicine systems worldwide for centuries. These plants contain a wide array of bioactive compounds, such as alkaloids, flavonoids, terpenoids, and polyphenols, which exert therapeutic effects through interactions with specific molecular targets [7,8]. However, elucidating the intricate relationships between these compounds and their targets has proven challenging [2].

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Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys of wistar rats against sodium fluoride induced oxidative stress

Cited by 7 publications

References 45 publications

Ameliorative Effect of Polyherbal Formulation for Restoring Liver Health: A Systematic Review

Ameliorative Effect of Polyherbal Formulation for Restoring Liver Health: A Systematic Review

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Advancement of Network Pharmacology in Multi-targeted Therapeutic Evaluation of Medicinal Plants

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