Ameliorative Effects of <i>Spirulina platensis</i> on Deltamethrin-Induced Biochemical Alterations and Oxidative Stress in the African Catfish; <i>Clarias gariepinus</i>

Abstract

The present study was carried out to determine LC 50 of deltamethrin (DM) in the African catfish; Clarias gariepinus, investigate its effects on the biochemical parameters and the antioxidant status of various tissues, and assess the protective role of Spirulina platensis (SP) against DM induced toxicity in C. gariepinus. The fish were distributed into seven groups of 10 fish/each for 30 days as follows: Group 1, control; Group 2, orally administered saline; Group 3, oral SP (150 mg/kg b.w.); Group 4, exposed to 5.19 µg/l DM; Group 5, exposed to 5.19 µg/l DM and orally administered SP (150 mg/kg b.w.); Group 6, exposed to 12.97 µg/l DM; and Group 7, exposed to 12.97 µg/l DM and orally administered SP (150 mg/kg b.w.). Results revealed marked elevation in serum AST, ALT, ALP, creatinine, urea and uric acid. Significant decrease in serum total protein and albumin was recorded. At the same time, the level of malondialdehyde (MDA) was significantly increased in liver, kidney and gills. While, tissue level of GSH and, SOD, CAT and GSH-Px activities were reduced. Treatment with SP improved the biochemical parameters and attenuated the DM induced oxidative damage. Therefore, this study confirmed the protective role of SP as an antioxidant against the toxicity of DM in catfish.

Effect of bisphenol A toxicity on growth performance, biochemical variables, and oxidative stress biomarkers of Nile tilapia,Oreochromis niloticus(L.)

“…In the present study, lowest values of total protein, albumin, and globulin were observed in fish exposed to 3.28 µg BPA/L as compared with the control fish ( p < 0.05; Table ). These findings agreed with that recorded in African catfish after pesticide exposure (Hamed, ; Marzouk et al, ; Sayed & Hamed, ). The depletion of serum total protein, albumin, and globulin in the BPA‐exposed fish may be a result of dysfunctions of the liver and kidney (Girón‐Pérez et al, ).…”

“…Similarly, elevated levels of serum AST, ALT, and ALP levels in BPA‐exposed animals compared to a control group were observed in rats (Ahmed, Moselhy, & Nabil, ; Korkmaz, Ahbab, Kolankaya, & Barlas, ) and fish (Hamed & Abdel‐Tawwab, ). Additionally, similar results were reported in activities of liver enzymes of African catfish upon exposure to 4‐NP (Sayed & Hamed, ; Sayed, Mekkawy, & Mahmoud, ) and deltamethrin (Hamed, ), respectively.…”

Ameliorative role of chitosan nanoparticles against bisphenol-A induced behavioral, biochemical changes and nephrotoxicity in the African catfish, Clarias gariepinus

“…Catfish exposed to BPA exhibited hypoproteinaemia, hypoalbuminaemia, and hypoglobulinaemia compared to the control ones. These results agreed with that documented in African catfish after pesticide exposures (Hamed, 2016;Marzouk et al, 2012;Sayed and Hamed, 2017;Abdel-Tawwab and Hamed, 2018). The depletion of serum total protein, albumin, and globulin in the BPA-exposed fish may be a result of dysfunctions of the liver and kidneys (Giron-Pérez et al, 2007).…”

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“…The SOD and CAT system, the first line of defense system against oxidants varied according to the response of fish antioxidant system to counteract with the toxicity of metal exposure [31]. The increase in SOD and CAT enzymes may be due to the elimination of ROS from the cell induced by exposure to pollutants which convert superoxide anions (O 2 -) into H 2 O 2 and then into H 2 O and O 2 [32]. GST plays an important role in homeostasis, detoxification and clearance of many xenobiotic compounds.…”